A5073222093- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Gut microbiota and health
- Cancer Treatment and Pharmacology
- Cystic Fibrosis Research Advances
- Antifungal resistance and susceptibility
- Pediatric health and respiratory diseases
- Sirtuins and Resveratrol in Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Light effects on plants
- Chemotherapy-related skin toxicity
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Neutropenia and Cancer Infections
- Breast Cancer Treatment Studies
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Adipose Tissue and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Biotin and Related Studies
- Liver Disease Diagnosis and Treatment
University of Perugia
2016-2025
Islamic Azad University Medical Branch of Tehran
2023
King Fahd Medical City
2023
Horizon Discovery (United Kingdom)
2023
Institut Català d'Oncologia
2018
Hospital de Sant Pau
1995-2018
Bellvitge University Hospital
2018
Hospital Arnau de Vilanova
2018
Research Institute Hospital 12 de Octubre
2018
Hospital Universitari Sant Joan de Reus
2018
Organisms adapt to day-night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior metabolism. Although many effectors of the immune system are known follow daily oscillations, role clock response acute infections is not understood. Here we show that modulates inflammatory during infection with pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium). Mice infected S. were colonized higher levels developed...
Background Despite the great success, therapeutic benefits of immune checkpoint inhibitors (ICIs) in cancer immunotherapy are limited by either various resistance mechanisms or ICI-associated toxic effects including gastrointestinal toxicity. Thus, novel strategies that provide manageable side to existing ICIs would enhance and expand their efficacy application. Due its proven role development regulation, gut microbiome has gained increasing expectation as a potential armamentarium optimize...
Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive and innate immune cells respond to A. are present the endogenous repertoire of patients with IPA but infrequent cannot be consistently isolated expanded for adoptive immunotherapy. Therefore, we gene-engineered –specific chimeric antigen receptor (Af-CAR) T demonstrate their ability confer antifungal reactivity...
Circadian rhythms govern a wide variety of physiological and metabolic functions in many organisms, from prokaryotes to humans. We previously reported that silent information regulator 1 (SIRT1), NAD + -dependent deacetylase, contributes circadian control. In addition, SIRT1 activity is regulated cyclic manner virtue the oscillation coenzyme . Here we used specific activator compounds both vitro vivo. tested show activation alters CLOCK:BMAL1-driven transcription different systems....
Major mood disorders have been linked to abnormalities in circadian rhythms, leading disturbances sleep, mood, temperature, and hormonal levels. We provide evidence that ketamine, a drug with rapid antidepressant effects, influences the function of molecular machinery. Ketamine modulates CLOCK:BMAL1-mediated transcriptional activation when these regulators are ectopically expressed NG108-15 neuronal cells. Inhibition occurs dose-dependent manner is attenuated after treatment GSK3β antagonist...
The circadian system controls a large array of physiological and metabolic functions. molecular organization the clock is complex, involving various elements organized in feedback regulatory loops. Here we demonstrate that RelB subunit NFκB acts as repressor transcription. physically interacts with activator BMAL1 presence CLOCK to repress gene expression at promoter clock-controlled Dbp. repression independent negative regulator CRY. Notably, -/- fibroblasts have profound alterations genes...
Vulvovaginal candidiasis (VVC) is a common mucosal infection caused by Candida spp., most frequently albicans, which may become recurrent and severely impacting the quality of life susceptible women. Although it increasingly being recognized that damage mediated an exaggerated inflammatory response, current therapeutic approaches are only based on antifungals relieve symptomatology, but fail to definitely prevent recurrences. The unrestrained activation NLRP3 inflammasome with continuous...
Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by progressive course of cholestasis with inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis PSC. According to “leaky gut” hypothesis, gut alters permeability intestinal mucosa, translocation gut-derived products that enter enterohepatic circulation cause hepatic inflammation. Thus, administration molecules preserve epithelial integrity would represent promising...
Abstract The aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and microbial pathways. While much known about role played by downstream metabolites of each pathways in intestinal homeostasis, their lung immune homeostasis underappreciated. Here we have examined Trp hydroxylase/5-hydroxytryptamine (5-HT) pathway calibrating metabolism during Aspergillus fumigatus pneumonia. We found that 5-HT produced mast cells contributed to pathogen clearance infection...
OPINION article Front. Immunol., 29 January 2020Sec. Inflammation Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.00067
The circadian clock driven by the daily light–dark and temperature cycles of environment regulates fundamental physiological processes perturbations these sophisticated mechanisms may result in pathological conditions, including cancer. While experimental evidence is building up to unravel link between rhythms tumorigenesis, it becoming increasingly apparent that response antitumor agents similarly dependent on clock, given dependence each drug regulation cell cycle, DNA repair apoptosis....
Liver regeneration is a unique means of studying cell proliferation in vivo. Screening large cDNA library from regenerating liver has previously allowed us to identify and characterize cluster genes encoding proteins with important roles proliferative processes. Here, by examining different rat human tissues as well lines, we characterized highly conserved gene, guanylyl cyclase domain containing 1 (GUCD1), whose modulation occurs cycle progression vitro. High-level expression GUCD1...