Vinay K. Khanna

ORCID: 0000-0001-7615-4119
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About
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Research Areas
  • Heavy Metal Exposure and Toxicity
  • Pesticide Exposure and Toxicity
  • Retinal Diseases and Treatments
  • Neuroscience and Neuropharmacology Research
  • Parasites and Host Interactions
  • Carcinogens and Genotoxicity Assessment
  • Medicinal Plants and Neuroprotection
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Glaucoma and retinal disorders
  • Arsenic contamination and mitigation
  • Retinal Imaging and Analysis
  • Ocular Diseases and Behçet’s Syndrome
  • Aluminum toxicity and tolerance in plants and animals
  • Mosquito-borne diseases and control
  • Parasitic Infections and Diagnostics
  • Nerve injury and regeneration
  • Trace Elements in Health
  • Advanced Glycation End Products research
  • Environmental Toxicology and Ecotoxicology
  • Parkinson's Disease Mechanisms and Treatments
  • Curcumin's Biomedical Applications
  • Helminth infection and control
  • Pluripotent Stem Cells Research
  • Parasite Biology and Host Interactions

Kasturba Medical College, Manipal
2011-2024

Manipal Academy of Higher Education
2015-2024

Indian Institute of Toxicology Research
2014-2023

Academy of Scientific and Innovative Research
2015-2023

University of Lucknow
2017

Council of Scientific and Industrial Research
2008-2013

Indian Academy of Pediatrics
2011

Jamia Hamdard
2010

Institute of Genomics and Integrative Biology
2010

Edinburgh Royal Infirmary
1989

Samir K. Brahmachari Partha P. Majumder Mitali Mukerji Saman Habib Debasis Dash and 95 more Kunal Ray Samira Bahl Lalji Singh Abhay Sharma Susanta Roychoudhury Giriraj R. Chandak Kumarasamy Thangaraj Devendra Parmar Shantanu Sengupta Dwaipayan Bharadwaj Srikanta Kumar Rath Jagmohan Singh Ganga Nath Jha Komal Virdi Vadlamudi Raghavendra Rao Swapnil Sinha Ashok K. Singh Amit Mitra Shrawan K. Mishra Qadar Pasha Sridhar Sivasubbu Rajesh Pandey Aradhita Baral Prashant Singh Amitabh Sharma Jitender Kumar Tsering Stobdan Yasha Bhasin Chitra Chauhan Ashiq Hussain Elyanambi Sundaramoorthy SP Singh Arun Bandyopadhyay Krishanu Dasgupta A. K. Reddy Charles J. Spurgeon M. Mohd Idris Vinay K. Khanna Alok Dhawan M. Anand Ravi Shankar Ram Suresh Bharti Madhu Singh Arvind Pratap Singh Anwar Jamal Khan Parag P. Shah AB Pant Rupinder Kaur Kamlesh Bisht Ashok Kumar Manickam Chidambaram E. G. Wilson Antony Thangadurai Pankaj Jha Mahua Maulik Neelam Makhija Abdur Rahim Sangeeta Sharma Rupali Chopra Arun Kumar Rana Manickam Chidambaram Arindam Maitra Ruchi Chawla Suruchika Soni Preeti Khurana M. Nadeem Khan Sushanta Das Sutar Amit Tuteja K. Narayansamy Rachna Shukla Swami Prakash Swapna Mahurkar‐Joshi K. Radha Mani J. Hemavathi Seema Bhaskar Pankaj Khanna G. S. Ramalakshmi Shalini Mani Tripathi Nikita Thakur Balaram Ghosh Ritushree Kukreti Taruna Madan Ranjana Verma G. Sudheer Anubha Mahajan Sreenivas Chavali Rubina Tabassum Sandeep Grover Meenal Gupta Jyotsna Batra Amrendra Kumar Azim Nejatizadeh Mudit Vaid Swapan K. Das Shilpy Sharma

10.1007/s12041-008-0002-x article EN Journal of Genetics 2008-04-01

Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major hurdle for successful therapy in Parkinson's disease (PD), neurodegenerative disorder. Therefore, present study we designed neurotransmitter dopamine-loaded PLGA nanoparticles (DA NPs) to deliver brain. These slowly constantly released dopamine, showed reduced clearance plasma, quinone adduct formation, decreased autoxidation. DA NPs were internalized dopaminergic SH-SY5Y cells neurons substantia nigra...

10.1021/nn506408v article EN publisher-specific-oa ACS Nano 2015-03-31
Shilpi Aggarwal Sapna Negi Pankaj Jha Prashant Singh Tsering Stobdan and 95 more M. A. Qadar Pasha Saurabh Ghosh Anurag Agrawal Bhavana Prasher Mitali Mukerji Samir K. Brahmachari Partha P. Majumder Mitali Mukerji Saman Habib Debasis Dash Kunal Ray S. Bahl Lalji Singh Abhay Sharma Susanta Roychoudhury Giriraj R. Chandak Kumarasamy Thangaraj Devendra Parmar Shiladitya Sengupta Dwaipayan Bharadwaj Srikanta Kumar Rath J. Singh Ganga Nath Jha Komal Virdi Vadlamudi Raghavendra Rao Swapnil Sinha Ashish Kumar Singh Amit Mitra Shrawan K. Mishra Qadar Pasha Sridhar Sivasubbu Rajesh Pandey Aradhita Baral P. K. Singh Abhay Sharma Jitender Kumar Tsering Stobdan Yasha Bhasin C Chauhan Ashik Hussain Elayanambi Sundaramoorthy SP Singh Arun Bandyopadhyay Kamal Dasgupta A. K. Reddy Charles J. Spurgeon Mohammed M. Idris Vinay K. Khanna Uma Dhawan M. Anand Ravi Shankar Ram Suresh Bharti Mahendra Pratap Singh Ashish Pratap Singh Anwar Jamal Khan Parag P. Shah AB Pant Rupinder Kaur Kamlesh Bisht Satyam Kumar Agrawal Manickam Chidambaram Elizabeth Wilson Antony Thangadurai Pankaj Jha Mahua Maulik Namrata Kumar Makhija Abdur Rahim Surendra K. Sharma Rupali Chopra Palak Rana Manickam Chidambaram Arindam Maitra Ruchi Chawla Shivani Soni Preeti Khurana M. Nadeem Khan Sushanta Das Sutar Amit Tuteja K. Narayansamy Rammohan Shukla Satya Prakash Swapna Mahurkar‐Joshi K. Radha Mani J. Hemavathi S. Bhaskar Pankaj Khanna G. S. Ramalakshmi S. M. Tripathi Neelam Thakur B. Ghosh Ritushree Kukreti Taruna Madan Rajesh Verma G. Sudheer Anubha Mahajan

It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility likely lead more effective predictive marker discovery. We have previously used the Ayurvedic concept Prakriti , which relates phenotypic differences in individuals, including response external environment as well diseases, explore molecular between three types: Vata, Pitta, and Kapha . EGLN1 was one among 251 differentially expressed genes types. In present study,...

10.1073/pnas.1006108107 article EN Proceedings of the National Academy of Sciences 2010-10-18

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including antioxidant property, and has been suggested be use in treatment several diseases. The present study undertaken investigate the protective effect curcumin against lead-induced neurotoxicity rats. Exposure rats lead (50 mg/kg po) for 45 days caused increase lipid peroxidation (LPO) a decrease reduced glutathione (GSH) levels cerebellum, corpus striatum, hippocampus frontal cortex as...

10.1191/0960327103ht411oa article EN Human & Experimental Toxicology 2003-12-01

The aim of the study was to determine plasma nitric oxide (NO) and lipid peroxide (LPO) levels in diabetic retinopathy its association with severity disease.Prospective observational study.A total 60 consecutive cases 20 healthy controls were included.Severity graded according early treatment (ETDRS) classification. Photoreceptor inner segment ellipsoid band (ISel) disruption retinal pigment epithelium (RPE) alteration using spectral domain optical coherence tomography. Data statistically...

10.1111/ceo.12506 article EN Clinical and Experimental Ophthalmology 2015-02-13

Abstract The plethora of literature has supported the potential benefits Resveratrol (RV) as a life-extending well an anticancer compound. However, these two functional discrepancies resulted at different concentration ranges. Likewise, role on adult neurogenesis still remains controversial and less understood despite its documented health benefits. To gather insight into biological effects RV neurogenesis, we evaluated possible compound proliferation survival neural progenitor cells (NPCs)...

10.1038/srep28142 article EN cc-by Scientific Reports 2016-06-23

<ns5:p>Background Platelets play a crucial role in haemostasis and have emerging functions inflammation, particularly respiratory infections like pulmonary tuberculosis (PTB) pneumonia. The objective of this study was to investigate alterations platelet parameters their relationship with erythrocyte sedimentation rate (ESR) PTB pneumonia patients, comparing them healthy controls, evaluate diagnostic prognostic potential. Methods This retrospective case-control conducted at tertiary care...

10.12688/f1000research.161124.1 preprint EN cc-by F1000Research 2025-03-25

Abstract Exposure of rats to acrylamide (ACR) caused hind limb paralysis in 58% the animals on day 10 and decreased behavioural parameters, namely distance travelled, ambulatory time, stereotypic time basal movements compared with control group. These also had a decrease reduced glutathione (GSH) content glutathione‐S‐transferase (GST) activity corpus striatum an increase striatal dopamine receptors, as evident by binding 3 H‐spiperone membranes. Treatment ethanol:water (1:1) extract...

10.1002/ptr.854 article EN Phytotherapy Research 2002-05-01

The neuroprotective potential of ethanol:water (1:1) extract rhizomes Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia rats. A significant behavioural impairment Rota-Rod performance and grid walking was observed rats, 72 hours after MCAO as compared to sham-operated animals. These rats also exhibited an increase lipid peroxidation (cortex -157%, corpus striatum - 58%) a decrease glutathione levels 59%, 34%) superoxide dismutase (SOD)...

10.1191/0960327106ht613oa article EN Human & Experimental Toxicology 2006-03-18

Monocrotophos (MCP) is a commonly used organophosphorus (OP) pesticide. We studied apoptotic changes in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS), lipid peroxide (LPO), and the ratio of glutathione disulfide (GSSG)/reduced (GSH) was observed selected doses Following exposure MCP, levels protein mRNA expressions Caspase-3, Caspase-9, Bax, p53, P(21), Puma, cytochrome-c were significantly upregulated, whereas Bcl(2), Bcl(w), Mcl1 downregulated. TUNEL...

10.1021/tx100234m article EN Chemical Research in Toxicology 2010-10-19

Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS) decrease glutathione (GSH) levels were observed Following the exposure MCP (10−5 M), protein mRNA expressions caspase-3/9, Bax, Bcl2, P53, P21, GSTP1-1 significantly upregulated, whereas Bclw, Mcl1 downregulated. CYP1A1/1A2, 2B1/2B2, 2E1...

10.1371/journal.pone.0017757 article EN cc-by PLoS ONE 2011-03-21

Extensive use of synthetic pyrethroids has resulted in serious human health issues. Induction oxidative stress is an important mechanism action most pesticides including pyrethroids. In the present study, we have elucidated possible role bifenthrin-induced neurotoxicity. Adult male Wistar rats were administered bifenthrin (3.5 and 7 mg per kg body weight p.o.) for 30 days. Behavioral studies conducted on a set randomly selected from each treatment group after completion treatment....

10.1039/c7tx00205j article EN Toxicology Research 2017-10-12

Elevated serum vascular endothelial growth factor (VEGF) levels are associated with diabetic retinopathy (DR). Serum VEGF correlate vitreous levels. Neuroretinal changes occur even before the appearance of signs in DR. Role as a biomarker for DR has not been assessed. severity DR, was evaluated first time.Consecutive cases type 2 diabetes mellitus [without (no n = 38); non-proliferative (NPDR, proliferative (PDR, 40)] and healthy controls (n 40) were included. measured using enzyme linked...

10.1186/s40942-019-0179-6 article EN cc-by International Journal of Retina and Vitreous 2019-10-01

Abstract Memory loss is one of the most tragic symptoms Alzheimer’s disease. Our laboratory has recently demonstrated that ‘i-Extract’ Ashwagandha ( Withania somnifera ) restores memory in scopolamine (SC)-induced mice. The prime target i-Extract obscure. We hypothesize may primarily muscarinic subtype acetylcholine receptors regulate processes. present study elucidates key target(s) via cellular, biochemical, and molecular techniques a relevant amnesia mouse model primary hippocampal...

10.1038/s41598-019-48238-6 article EN cc-by Scientific Reports 2019-09-30

An in vitro model of ischemic cerebral stroke [oxygen-glucose deprivation (OGD) for 6 h followed by 24 reoxygenation (R)] with PC12 cells increases Ca(2+) influx upregulating native L-type channels and reactive oxygen species (ROS) generation. This generation increase intracellular triggers the expression hypoxic homeostasis transcription factors such as hypoxia induced factor-1 alpha (HIF-1α), Cav-beta 3 (Cav β3), signal transducer activator (STAT3), heat shock protein 27 (hsp-27), cationic...

10.1021/cn300143m article EN ACS Chemical Neuroscience 2012-10-29
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