A5058399126- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Retinal Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Parasites and Host Interactions
- Carcinogens and Genotoxicity Assessment
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Glaucoma and retinal disorders
- Arsenic contamination and mitigation
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Aluminum toxicity and tolerance in plants and animals
- Mosquito-borne diseases and control
- Parasitic Infections and Diagnostics
- Nerve injury and regeneration
- Trace Elements in Health
- Advanced Glycation End Products research
- Environmental Toxicology and Ecotoxicology
- Parkinson's Disease Mechanisms and Treatments
- Curcumin's Biomedical Applications
- Helminth infection and control
- Pluripotent Stem Cells Research
- Parasite Biology and Host Interactions
Kasturba Medical College, Manipal
2011-2024
Manipal Academy of Higher Education
2015-2024
Indian Institute of Toxicology Research
2014-2023
Academy of Scientific and Innovative Research
2015-2023
University of Lucknow
2017
Council of Scientific and Industrial Research
2008-2013
Indian Academy of Pediatrics
2011
Jamia Hamdard
2010
Institute of Genomics and Integrative Biology
2010
Edinburgh Royal Infirmary
1989
Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major hurdle for successful therapy in Parkinson's disease (PD), neurodegenerative disorder. Therefore, present study we designed neurotransmitter dopamine-loaded PLGA nanoparticles (DA NPs) to deliver brain. These slowly constantly released dopamine, showed reduced clearance plasma, quinone adduct formation, decreased autoxidation. DA NPs were internalized dopaminergic SH-SY5Y cells neurons substantia nigra...
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility likely lead more effective predictive marker discovery. We have previously used the Ayurvedic concept Prakriti , which relates phenotypic differences in individuals, including response external environment as well diseases, explore molecular between three types: Vata, Pitta, and Kapha . EGLN1 was one among 251 differentially expressed genes types. In present study,...
Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including antioxidant property, and has been suggested be use in treatment several diseases. The present study undertaken investigate the protective effect curcumin against lead-induced neurotoxicity rats. Exposure rats lead (50 mg/kg po) for 45 days caused increase lipid peroxidation (LPO) a decrease reduced glutathione (GSH) levels cerebellum, corpus striatum, hippocampus frontal cortex as...
The aim of the study was to determine plasma nitric oxide (NO) and lipid peroxide (LPO) levels in diabetic retinopathy its association with severity disease.Prospective observational study.A total 60 consecutive cases 20 healthy controls were included.Severity graded according early treatment (ETDRS) classification. Photoreceptor inner segment ellipsoid band (ISel) disruption retinal pigment epithelium (RPE) alteration using spectral domain optical coherence tomography. Data statistically...
Abstract The plethora of literature has supported the potential benefits Resveratrol (RV) as a life-extending well an anticancer compound. However, these two functional discrepancies resulted at different concentration ranges. Likewise, role on adult neurogenesis still remains controversial and less understood despite its documented health benefits. To gather insight into biological effects RV neurogenesis, we evaluated possible compound proliferation survival neural progenitor cells (NPCs)...
<ns5:p>Background Platelets play a crucial role in haemostasis and have emerging functions inflammation, particularly respiratory infections like pulmonary tuberculosis (PTB) pneumonia. The objective of this study was to investigate alterations platelet parameters their relationship with erythrocyte sedimentation rate (ESR) PTB pneumonia patients, comparing them healthy controls, evaluate diagnostic prognostic potential. Methods This retrospective case-control conducted at tertiary care...
Abstract Exposure of rats to acrylamide (ACR) caused hind limb paralysis in 58% the animals on day 10 and decreased behavioural parameters, namely distance travelled, ambulatory time, stereotypic time basal movements compared with control group. These also had a decrease reduced glutathione (GSH) content glutathione‐S‐transferase (GST) activity corpus striatum an increase striatal dopamine receptors, as evident by binding 3 H‐spiperone membranes. Treatment ethanol:water (1:1) extract...
The neuroprotective potential of ethanol:water (1:1) extract rhizomes Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia rats. A significant behavioural impairment Rota-Rod performance and grid walking was observed rats, 72 hours after MCAO as compared to sham-operated animals. These rats also exhibited an increase lipid peroxidation (cortex -157%, corpus striatum - 58%) a decrease glutathione levels 59%, 34%) superoxide dismutase (SOD)...
Monocrotophos (MCP) is a commonly used organophosphorus (OP) pesticide. We studied apoptotic changes in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS), lipid peroxide (LPO), and the ratio of glutathione disulfide (GSSG)/reduced (GSH) was observed selected doses Following exposure MCP, levels protein mRNA expressions Caspase-3, Caspase-9, Bax, p53, P(21), Puma, cytochrome-c were significantly upregulated, whereas Bcl(2), Bcl(w), Mcl1 downregulated. TUNEL...
Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS) decrease glutathione (GSH) levels were observed Following the exposure MCP (10−5 M), protein mRNA expressions caspase-3/9, Bax, Bcl2, P53, P21, GSTP1-1 significantly upregulated, whereas Bclw, Mcl1 downregulated. CYP1A1/1A2, 2B1/2B2, 2E1...
Extensive use of synthetic pyrethroids has resulted in serious human health issues. Induction oxidative stress is an important mechanism action most pesticides including pyrethroids. In the present study, we have elucidated possible role bifenthrin-induced neurotoxicity. Adult male Wistar rats were administered bifenthrin (3.5 and 7 mg per kg body weight p.o.) for 30 days. Behavioral studies conducted on a set randomly selected from each treatment group after completion treatment....
Elevated serum vascular endothelial growth factor (VEGF) levels are associated with diabetic retinopathy (DR). Serum VEGF correlate vitreous levels. Neuroretinal changes occur even before the appearance of signs in DR. Role as a biomarker for DR has not been assessed. severity DR, was evaluated first time.Consecutive cases type 2 diabetes mellitus [without (no n = 38); non-proliferative (NPDR, proliferative (PDR, 40)] and healthy controls (n 40) were included. measured using enzyme linked...
Abstract Memory loss is one of the most tragic symptoms Alzheimer’s disease. Our laboratory has recently demonstrated that ‘i-Extract’ Ashwagandha ( Withania somnifera ) restores memory in scopolamine (SC)-induced mice. The prime target i-Extract obscure. We hypothesize may primarily muscarinic subtype acetylcholine receptors regulate processes. present study elucidates key target(s) via cellular, biochemical, and molecular techniques a relevant amnesia mouse model primary hippocampal...
An in vitro model of ischemic cerebral stroke [oxygen-glucose deprivation (OGD) for 6 h followed by 24 reoxygenation (R)] with PC12 cells increases Ca(2+) influx upregulating native L-type channels and reactive oxygen species (ROS) generation. This generation increase intracellular triggers the expression hypoxic homeostasis transcription factors such as hypoxia induced factor-1 alpha (HIF-1α), Cav-beta 3 (Cav β3), signal transducer activator (STAT3), heat shock protein 27 (hsp-27), cationic...