A5008883488- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Neuroprotection
- Neuroscience and Neuropharmacology Research
- Curcumin's Biomedical Applications
- Carcinogens and Genotoxicity Assessment
- Arsenic contamination and mitigation
- Aluminum toxicity and tolerance in plants and animals
- Retinoids in leukemia and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Genomics, phytochemicals, and oxidative stress
- Nanoparticle-Based Drug Delivery
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Pluripotent Stem Cells Research
- Pesticide and Herbicide Environmental Studies
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Nanoparticles: synthesis and applications
- Computational Drug Discovery Methods
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Essential Oils and Antimicrobial Activity
- Sirtuins and Resveratrol in Medicine
Indian Institute of Toxicology Research
2016-2025
Council of Scientific and Industrial Research
2009-2025
Academy of Scientific and Innovative Research
2015-2025
Graphic Era University
2024
University of Lucknow
2015-2023
Maharshi Dayanand University
2023
University of Petroleum and Energy Studies
2023
University of Nizwa
2023
In-Q-Tel
2015
Central Institute of Medicinal and Aromatic Plants
2014
Large reductions in the thermal conductivity of thermoelectrics using nanostructures have been widely demonstrated. Some enhancements thermopower through nanostructuring also reported. However, these improvements are generally offset by large drops electrical due to a drastic reduction mobility. Here, we show that and half-Heusler (HH) phases can be achieved simultaneously at high temperatures coherent insertion nanometer scale full-Heusler (FH) inclusions within matrix. The HH/FH...
Multi-walled carbon-nanotubes (MWCNTs)-induced apoptotic changes were studied in human lung epithelium cell line-A549. Non-cytotoxic doses of MWCNTs identified using tetrazolium bromide salt (MTT) and lactate dehydrogenase (LDH) release assays. Cells exposed to (0.5–100 μg/ml) for 6–72 h. Internalization characterization CNTs was performed by electron microscopy. Apoptotic estimated nuclear condensation, DNA laddering, confirmed expression associated markers: p53, p21WAF1/CIP1, Bax, Bcl2...
Abstract The generation of differentiated and functional neurons is a complex process, which requires coordinated expression several proteins microRNAs (miRNAs). present study using nerve growth factor (NGF)‐differentiated PC12 cells led to the identification miR‐200, miR‐221/222 miR‐34 families as major up‐regulated miRNAs in fully neurons. Similar cells, induction miR‐200 family was observed differentiating neural stem demonstrating direct role neuronal differentiation. Over‐expression...
Abstract The plethora of literature has supported the potential benefits Resveratrol (RV) as a life-extending well an anticancer compound. However, these two functional discrepancies resulted at different concentration ranges. Likewise, role on adult neurogenesis still remains controversial and less understood despite its documented health benefits. To gather insight into biological effects RV neurogenesis, we evaluated possible compound proliferation survival neural progenitor cells (NPCs)...
Ciprofloxacin is a widely used fluoroquinolone drug with broad spectrum antibacterial activities. Clinical experience has shown incidences of adverse effects related to skin, hepatic, central nervous system, gastrointestinal and phototoxicity. India tropical country sunlight abundant throughout the day. In this scenario exposure ambient levels ultraviolet radiation (UV-R) in may lead harmful ciprofloxacin users. Phototoxicity assessment was studied by two mouse fibroblast cell lines L-929...
Monocrotophos (MCP) is a commonly used organophosphorus (OP) pesticide. We studied apoptotic changes in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS), lipid peroxide (LPO), and the ratio of glutathione disulfide (GSSG)/reduced (GSH) was observed selected doses Following exposure MCP, levels protein mRNA expressions Caspase-3, Caspase-9, Bax, p53, P(21), Puma, cytochrome-c were significantly upregulated, whereas Bcl(2), Bcl(w), Mcl1 downregulated. TUNEL...
Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS) decrease glutathione (GSH) levels were observed Following the exposure MCP (10−5 M), protein mRNA expressions caspase-3/9, Bax, Bcl2, P53, P21, GSTP1-1 significantly upregulated, whereas Bclw, Mcl1 downregulated. CYP1A1/1A2, 2B1/2B2, 2E1...
An in vitro model of ischemic cerebral stroke [oxygen-glucose deprivation (OGD) for 6 h followed by 24 reoxygenation (R)] with PC12 cells increases Ca(2+) influx upregulating native L-type channels and reactive oxygen species (ROS) generation. This generation increase intracellular triggers the expression hypoxic homeostasis transcription factors such as hypoxia induced factor-1 alpha (HIF-1α), Cav-beta 3 (Cav β3), signal transducer activator (STAT3), heat shock protein 27 (hsp-27), cationic...
ABSTRACT Quercetin ( QT ), a dietary‐derived flavonoid, is ubiquitous in fruits and vegetables plays an important role human health by virtue of its antioxidant function. The present study was designed to examine the effects on oxidative damage that induced herbicide, atrazine ATZ mixed cultures Sertoli‐germ cells. Results showed treatment with increased cell viability decreased catalase activity, malondialdehyde, reactive oxygen species ROS ) levels. also m RNA expression glutathione...
Kolaviron (KV), a natural biflavonoid obtained from the seeds of Garcinia kola, has been documented for its wide pharmacological window, including anti-apoptotic activities. However, underlying mechanisms are poorly understood at cellular level. This study investigates activity KV in PC12 cells, rat pheochromocytoma, exposed to endocrine disruptor-atrazine (ATZ). (60 μM) treatment 24 h shows significant responses cells ATZ (232 h. recovers ATZ-induced levels malondialdehyde, reactive oxygen...