A5022687954- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Advanced Fiber Laser Technologies
- Photonic and Optical Devices
- UAV Applications and Optimization
- Photorefractive and Nonlinear Optics
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Lipid Membrane Structure and Behavior
- Photosynthetic Processes and Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Robotic Path Planning Algorithms
- Distributed Control Multi-Agent Systems
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- melanin and skin pigmentation
- Semiconductor Quantum Structures and Devices
- Air Traffic Management and Optimization
- Software Engineering Research
- Indoor and Outdoor Localization Technologies
- Virus-based gene therapy research
- Advanced Wireless Communication Technologies
- Crystallography and molecular interactions
East China Normal University
2012-2025
Institute of Genetics and Developmental Biology
2024
Chinese Academy of Sciences
2024
Fudan University
2003-2023
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
State Key Laboratory of Genetic Engineering
2020
Peking University First Hospital
2019
Peking University
2019
Institute of Pharmacology
2017-2018
With excellent flexibility, unmanned aerial vehicles (UAVs) can act as airborne computing servers to assist smart terminals (STs) with their computationally-intense and delay-sensitive tasks. This paper presents a new UAV-assisted edge framework, which jointly optimizes the trajectory CPU frequency of fixed-wing UAV, offloading schedule minimize energy consumption UAV. The key idea is that we reveal condition for convexity optimization, when UAV flies linear trajectory. Under condition,...
Intelligent reflecting surface (IRS) has been increasingly considered in mobile edge computing (MEC), assisting smart terminals (STs) offloading computationally-intense tasks to base stations (BSs). This paper presents a new IRS-assisted MEC framework, which jointly optimizes the local CPU frequencies of STs, receive beamformers BS, ST schedules, and IRS phase configuration, minimize energy consumption STs. To this end, we reveal that optimal frequency is time-invariant for each ST. Under...
We demonstrate fabrication of a 30-cm-long thin-film lithium niobate (TFLN) optical delay line (ODL) incorporated with segmented microelectrodes 24-cm total length using the femtosecond laser lithography technique. The transmission spectra unbalanced Mach-Zehnder interferometers (MZIs) reveal an ultra-low propagation loss 0.025 dB/cm. device exhibits low half-wave voltage 0.45 V, corresponding to voltage-length product 10.8 V·cm, which is equivalent 5.4 V·cm in push-pull configuration. also...
Base editing is a powerful tool for artificial evolution to create allelic diversity and improve agronomic traits. However, the great evolutionary potential every sgRNA target has been overlooked. And there currently no high-throughput method generating characterizing as many changes in single possible based on large mutant pools permit rapid gene directed plants.
The structural and functional properties of the visual system are disrupted in mutant animals lacking beta2 subunit nicotinic acetylcholine receptor. In particular, eye-specific retinogeniculate projections do not develop normally these mutants. It is widely thought that developing retinas beta2(-/-) mutants manifest correlated activity, leading to notion retinal waves play an instructional role formation projections. By multielectrode array recordings, we show here have robust during Unlike...
Photonic-integrated circuits based on erbium-doped thin film lithium niobate insulator has attracted broad interests with insofar various waveguide amplifiers and microlasers demonstrated. Wideband operation facilitated by the broadband absorption emission of erbium ions necessitates functional integration wavelength filter multiplexer same chip. Here, a low-loss division at resonant pumping wavelengths (∼1480 nm 1530-1560 nm) angled multimode interferometer is realized in fabricated...
Mitochondrial complex I (NADH dehydrogenase) is a major contributor to neuronal energetics, and mutations in lead vision loss.Functional, neuroanatomical transcriptional consequences of deficiency were investigated retinas the Ndufs4 knockout mouse.Whole-eye ERGs multielectrode arrays confirmed retinal ganglion cell functional loss at P32, P42. RNAseq demonstrated mild then sharp increase innate immune inflammatory transcripts P22 P33, respectively, which with QRT-PCR.Intraperitoneal...
Deep learning (DL) has been widely applied to many domains. Unique challenges in engineering DL systems are posed by the programming paradigm shift from traditional systems, and performance is one of challenges. Performance problems (PPs) can cause severe consequences such as excessive resource consumption financial loss. While bugs have extensively investigated, PPs hardly explored. To bridge this gap, we present first comprehensive study i) characterize symptoms, root causes, introducing...
Fixed-wing unmanned aerial vehicles (UAVs) provide a practical means for data collection in many Internet-of-Things (IoT) applications. Secrecy and energy efficiency are crucial to the collection, but have never been well addressed lack of appropriate propulsion models three-dimensional (3D) flights fixed-wing UAVs. This paper delivers new approach joint optimization 3D flight trajectory schedule UAV secure energy-efficient under an eavesdropping attack. A critical aspect is that we derive...
This paper presents a new three-dimensional (3D) trajectory design approach for solar-powered, fixed-wing unmanned aerial vehicle (UAV) to harvest solar energy and collect data from multiple smart devices (SDs). The is optimized based on max-min fairness balance the total amount of uploaded among SDs. key idea that we develop non-trivial variable substitution successive convex approximation (SCA) techniques convexify transmission, UAV consumption mobility, harvesting constraints under...
This study presents the design and evaluation of a series multifunctional peptides their gene delivery abilities. The peptide sequences contained cell-penetrating segment, six continuous histidine residues, stearyl moiety laminin receptor-targeting segment. YIGSR segment promoted cellular uptake through interaction with receptors on surface cells, which resulted in great improvement transfection efficiency. conformation, particle size zeta potential peptide/DNA complexes were characterized...
Abstract Thin‐film lithium niobate (TFLN) based optical microresonators offer large nonlinear coefficient d 33 and high light‐field confinement, allowing highly efficient second‐order frequency conversion. Here, ultra‐efficiency SHG from high‐Q polygon modes is achieved by maximizing the utilization of highest in a monocrystalline X‐cut TFLN microdisk resonator for first time. The are designed formed with two parallel sides perpendicular to axis crystal introducing weak perturbations into...
Epibatidine (EPI), a potent cholinergic agonist, disrupts acetylcholine-dependent spontaneous retinal activity. Early patch-clamp recordings in juvenile ferrets suggested that EPI blocks all ganglion cell (RGC) action potentials when applied to the retina. In contrast, recent experiments on developing mouse relied multielectrode array (MEA) reported application decorrelates activity of neighboring RGCs and eliminates waves while preserving spiking many neurons. The different techniques used...
Photolithography assisted chemo-mechanical etching (PLACE), a technique specifically developed for fabricating high-quality large-scale photonic integrated circuits (PICs) on thin-film lithium niobate (TFLN), has enabled fabrication of series building blocks PICs ranging from (high-Q) micro-resonators and low-loss waveguides to electrooptically (EO) tunable lasers waveguide amplifiers. Aiming at high-throughput manufacturing the PIC devices systems, we have an ultra-high-speed...
Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but feature(s) of critical for retinogeniculate refinement are controversial. Pharmacologically or genetically manipulating cholinergic signaling SRA perturbs correlated ganglion cell (RGC) spiking and disrupts retinofugal in vivo, consistent with an instructive role visual system development. Paradoxically, ablating starburst amacrine cells (SACs) that...