A5058287639- Influenza Virus Research Studies
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Autoimmune Neurological Disorders and Treatments
- Biosensors and Analytical Detection
- Streptococcal Infections and Treatments
- Genomics and Chromatin Dynamics
- Bacterial Infections and Vaccines
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Peripheral Neuropathies and Disorders
- Antifungal resistance and susceptibility
- Cystic Fibrosis Research Advances
- Cerebrovascular and genetic disorders
- Plant Molecular Biology Research
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
- Drug-Induced Ocular Toxicity
- Neonatal Respiratory Health Research
- RNA Research and Splicing
- Immune Response and Inflammation
University of Utah
2017-2023
Cotton (United States)
2022
ARUP Laboratories (United States)
2022
University of South Dakota
2011-2019
Great Basin College
2009-2014
Salt Lake Regional Medical Center
2014
Colorado State University
2006-2009
Mg2+-dependent oligomerization of nucleosomal arrays is correlated with higher order folding transitions that stabilize chromosome structure beyond the 30-nm diameter fiber. In present studies, we have employed a novel mutagenesis-based approach to identify macromolecular determinants control H4 N-terminal domain (NTD) function during oligomerization. Core histones were engineered in which 1) H2A, H2B, and H3 NTDs swapped onto histone fold; 2) length NTD H2A on fold, increased; 3) charge...
Please cite this paper as: Cwach et al. (2011) Contribution of murine innate serum inhibitors toward interference within influenza virus immune assays. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2011.00283.x. Background Prior to detection an antibody response viruses using the hemagglutination inhibition assay (HAI), sera are routinely treated inactivate both heat inactivation (56°C) recombinant neuraminidase [receptor‐destroying enzyme (RDE)]. Objectives We revisited...
Lower airway abnormalities are common in patients with primary ciliary dyskinesia (PCD), a pediatric syndrome that results from structural or functional defects motile cilia. Patients can suffer recurrent bacterial infection the lung, bronchiectasis, and respiratory distress addition to chronic sinusitis, otitis media, infertility, laterality defects. However, surprisingly little is known about pulmonary phenotype of mouse models this disorder.The two PCD, nm1054 bgh, which lack Pcdp1 Spef2,...
Influenza virus infections can be complicated by bacterial superinfections, which are medically relevant because of a complex interaction between the host, virus, and bacteria. Studies to date have implicated several influenza genes, varied host immune responses, virulence factors, however, host–pathogen interactions that predict survival versus lethal outcomes remain undefined. Previous work our group showed certain viruses could yield phenotype (A/swine/Texas/4199-2/98-H3N2, TX98), whereas...
Influenza A viruses (IAVs) have multiple mechanisms for altering the host immune response to aid in virus survival and propagation. While both type I II interferons (IFNs) been associated with increased bacterial superinfection (BSI) susceptibility, we found that some cases IFNs can be beneficial BSI outcome. Specifically, shown antagonism of IFN during infection by IAVs lead development deadly BSI. The nonstructural protein 1 (NS1) from IAV is well known manipulating responses, but viral...
Fungal bloodstream infections are a significant problem in the United States, with an attributable mortality rate of up to 40%. An early diagnosis direct appropriate therapy has been shown be critical reduce rates. Conventional phenotypic methods for fungal detection take several days, which is often too late impact outcomes. Herein, we describe cost-effective multiplex assay platform rapid and differentiation major clinically relevant Candida species directly from blood culture. This...
A non-instrumented molecular diagnostics approach is described which integrates HDA amplification and thin film biosensor detection to create a platform capable of detecting pathogenic bacteria with high sensitivity specificity.
<h3>Objective:</h3> We present a case of HCQ-induced neuromyopathy culminating in reversible respiratory failure. <h3>Background:</h3> Hydroxychloroquine (HCQ) induced is well-documented but rare side effect HCQ. Here, we discuss There are few documented cases fulminant failure requiring mechanical ventilation due to this severe neuromuscular complication <h3>Design/Methods:</h3> A 58-year-old female with systemic lupus erythematous on HCQ for 15 years presented peripheral edema and acute...
Abstract Type I interferon (IFN) signaling is a known contributor to increased host susceptibility deadly bacterial super-infections (BSIs) following influenza A virus (IAV) pandemics. However, many IAV infections never develop secondary complications, suggesting that viral-derived factors can influence BSIs. Utilizing reverse genetics we found natural variation in nonstructural protein (NS1) could directly affect the duration of IFNβ signaling, which turn affected mice Specifically,...
OBJECTIVES/SPECIFIC AIMS: This poster presents preliminary results of using in silico approaches to predict a priori, based on sequence alone, the pathogenesis novel influenza A virus. METHODS/STUDY POPULATION: Here we analyzed structure NS1 protein 11 strains well characterized virus with known pathogenesis, reported literature as LD50 values, and published sequences. We performed homology comparison these sequences ExPASy SIM alignment tool for then predicted their 3D structures I-TASSER...
Wednesday, April 29April 14, 2020Free AccessAutoantibody Prevalence in Cerebrospinal Fluid Autoimmune Encephalitis and Related Disorders: The Need for a More Targeted Screening Approach (4897)Thomas R. Haven, Joshua M. Klonoski, Lisa K. PetersonAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.4897 Letters to the Editor
Abstract Introduction/Objective Ghana has a population of over 31 million people and approximately 15 neurosurgeons but is currently without dedicated neuropathologist. Here we present month neuropathology outreach performed at the Komfo Anokye Teaching Hospital (KATH) in Kumasi Korle-Bu (KBTH) Accra. Methods/Case Report In February 2022, second-year fellow board-certified neuropathologist traveled to give 40 1.5 hour didactic interactive teaching sessions. A two-week format was developed...