A5014629899- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Immune Response and Inflammation
- Intensive Care Unit Cognitive Disorders
- Cardiac Valve Diseases and Treatments
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Inflammation biomarkers and pathways
- Renal function and acid-base balance
- Pharmacological Effects of Natural Compounds
- Additive Manufacturing Materials and Processes
- Clusterin in disease pathology
- Additive Manufacturing and 3D Printing Technologies
- Acute Kidney Injury Research
- Pediatric health and respiratory diseases
- Nosocomial Infections in ICU
- Neonatal and Maternal Infections
- Liver Disease and Transplantation
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Shanghai Clinical Research Center
2022-2024
Civil Aviation University of China
2022
Sun Yat-sen University Cancer Center
2012-2021
Third Affiliated Hospital of Sun Yat-sen University
2012
Sixth Affiliated Hospital of Sun Yat-sen University
2012
Nanjing General Hospital of Nanjing Military Command
2006
Abstract Introduction Severe sepsis is associated with a high mortality rate despite implementation of guideline recommendations. Adjunctive treatment may be efficient and require further investigation. In light the crucial role immunologic derangement in severe sepsis, thymosin alpha 1 (Tα1) considered as promising beneficial immunomodulatory drug. The trial to evaluate whether Tα1 improves 28-day all-cause rates immunofunction patients sepsis. Methods We performed multicenter randomized...
Abstract Introduction Many studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for mortality in severe septic patients. On the contrary, other found mHLA-DR was not useful prognostic marker sepsis. Few taken changes of during treatment into consideration. The objective this study to estimate value predict Methods In prospective observational study, measured by flow cytometry peripheral blood from 79 adult patients with levels were...
Immunosuppression is a risk factor for poor prognosis of critically ill patients, but current monitoring the immune status in clinical practice still inadequate. Absolute lymphocyte count (ALC) not only convenient biomarker also suitable application. In this study, we aimed to explore different trajectories ALC, and evaluate their relationship with patients. We retrospectively enrolled 10,619 patients admitted general intensive care unit (ICU) 56 beds from February 2016 May 2020. Dynamic ALC...
Improvement of fat digestion and absorption was supposed to relieve feeding intolerance. This trial aimed evaluate the effect a fat-modified enteral formula on tolerance in critically ill patients.This conducted 7 hospitals China. In total, 144 intensive care unit (ICU) patients with estimated need nutrition (EN) for at least 5 days were randomly given containing medium-chain triglycerides (MCT), carnitine, taurine (interventional feed group, n = 71) or standard (control 73). EN intake,...
Excessive tachycardia is associated with impaired hemodynamics and worse outcome in critically ill patients. Previous studies suggested beneficial effect of β-blockers administration ICU patients, including those septic shock. However, comparisons settings are lacking. Our study aims to compare Landiolol Esmolol regarding heart rate control hemodynamic variables general This retrospective, observational was conducted a 56-bed at university hospital. A propensity score matching (PSM) employed...
Myoglobin is an important biomarker for monitoring critically ill patients. However, the relationship between its dynamic changes and prognosis remains unclear. We retrospectively enrolled 11,218 patients from a general surgical intensive care unit (ICU) of tertiary hospital June 2016 May 2020. Patients with acute cardiovascular events, cardiac major vascular surgeries, rhabdomyolysis were excluded. To investigate early myoglobin distribution, stratified according to highest level within 48...
Autophagy, part of the innate immune defense mechanisms, is activated during initial phase septic insult. Previous studies indicated that micro (mi)RNAs are additionally involved in host response to sepsis; however, association between miRNAs and autophagy this process not fully understood. To study role miRNA (miR)‑23a initiated by sepsis, macrophages treated with lipopolysaccharides, addition blood samples from patients, were evaluated for miR‑23a expression levels. Cell viability,...
Ciprofol was approved for use in intensive care unit (ICU) patients requiring sedation during mechanical ventilation July 2022. A pooled post-hoc analysis of phase 2 and 3 trials conducted primarily to explore hypotension-free outcome ICU who required achieved the target light goal at an early stage after being sedated with ciprofol or propofol.
ABSTRACT Fluid overload is associated with increased morbidity and mortality in critically ill patients. However, researches rarely study the precise start or end point of fluid removal no protocol was developed to control process. We hypothesized that individualized ultrasound-guided could improve efficacy safety post-resuscitated A quasi-experimental, before after trial conducted identify benefits removal. performed either following doctor's experience Control group, abiding ultrasound...
Transesophageal echocardiography (TEE) performed by intensivists is increasingly used in critically ill patients. However, TEE usually not the preferred monitoring tool, especially when transthoracic (TTE) appears to have addressed clinical problems. As a result, it remains largely unknown whether clinically valuable replacement or supplement for TTE as primary tool evaluating haemodynamic problems surgical The purpose of this study was assess diagnostic and therapeutic value instead...
Imbalance in mitochondrial fusion/fission is one of the mechanisms leading to sepsis‑induced dysfunction and cell apoptosis. The present study examined effects human trypsin inhibitor (UTI), a well‑known antioxidant anti‑inflammatory substance, on dynamics apoptosis lipopolysaccharide (LPS)‑induced kidney‑2 (HK‑2) cells. HK‑2 cells were incubated for 24 h either with LPS (800 ng/ml) or mixed UTI (250 U/ml). Cell viability was assessed using a3‑(4,5‑dimethyl‑2‑thiazolyl)‑2,...
Background Many studies have shown that continuous renal replacement therapy (CRRT) could clean lactate and treat the hyper-lactatemia. On contrary, some other found filter clearance only accounted for a very small part of total hemofilter's contribution to overall was negligible. The objective this study evaluate effects various doses veno-venous hemofiltration (CVVH) on plasma elimination in critically ill patients. Methods Patients were divided into three groups according their incipient...
Following long‑term exposure to endotoxins, macrophages enter an immunosuppressive state that renders them unable respond subsequent exposures endotoxin, a phenomenon is termed ʻendotoxin toleranceʼ. Endotoxin tolerance increases the risks of secondary infection and mortality in patients with sepsis. In endotoxin‑tolerant macrophages, mixed variation gene transcription referred as macrophage reprogramming. The mechanisms underlying reprogramming remain unclear at present. Interferon‑induced...
An acute respiratory distress syndrome (ARDS) is still one of the major challenges in critically ill patients. This study aimed to investigate effect inhibiting c-Jun N-terminal kinase (JNK) on ARDS a lipopolysaccharide (LPS)-induced rat model.Thirty-six rats were randomized into three groups: control, LPS, and LPS + JNK inhibitor. Rats sacrificed 8 h after treatment. The lung edema was observed by measuring wet-to-dry weight (W/D) ratio lung. severity pulmonary inflammation myeloperoxidase...