A5023300907- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Telemedicine and Telehealth Implementation
- Systemic Lupus Erythematosus Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Mental Health and Psychiatry
- Global Healthcare and Medical Tourism
- Long-Term Effects of COVID-19
- Mental Health Treatment and Access
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Spine and Intervertebral Disc Pathology
- Hepatitis C virus research
- Soft tissue tumor case studies
- Autoimmune and Inflammatory Disorders Research
- COVID-19 and Mental Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Diseases and Immunity
- Vaccine Coverage and Hesitancy
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Myasthenia Gravis and Thymoma
- Urinary and Genital Oncology Studies
Queen Elizabeth Hospital Birmingham
2025
NIHR Surgical Reconstruction and Microbiology Research Centre
2024
University Hospitals of Leicester NHS Trust
2020-2023
University Hospitals Coventry and Warwickshire NHS Trust
2023
University of Birmingham
2023
Leicester Royal Infirmary
2022
National Health Service
2021
University of Leicester
2021
Coventry and Warwickshire Partnership NHS Trust
2019-2021
Abstract Background/Aims Voclosporin is a novel calcineurin inhibitor approved for the treatment of lupus nephritis (LN) in UK 2023. We present our current local experience using voclosporin at Queen Elizabeth Hospital Birmingham. Methods Routinely collected clinical data were reviewed patients commencing baseline, 3- and 6-months time-points. Data are presented as median (interquartile ranges). Results Fourteen started voclosporin: three had de novo LN, eight LN refractory to previous...
Objectives This study sets out to ascertain if recognition of delirium impacts on patient outcomes. Design Retrospective cohort study. Setting Unscheduled admissions acute care trust/secondary UK hospitals. Participants Six hundred and fifty-six older adults aged ≥65 years admitted 14 September 2018. Measurements Delirium was ascertained retrospectively from case notes using medical notes. Documented classified as recognised unrecognised delirium. Primary secondary outcome measures measure:...
The pandemic has resulted in many changes to health services, one of these is the shift from face-to-face consultations virtual ones across all specialities. As continues with no end sight it seems that will continue for foreseeable future. In this article, we analyze patient feedback so far a large tertiary center and use opportunity reflect on new service. We have particular interest musculoskeletal services as largely an outpatient-based speciality consequently significant practice. also...
Psychiatric patients are at high risk of developing physical health complications. This is due to various factors including medications prescribed, life style choices and diagnostic overshadowing. Admission a psychiatric unit provides prime opportunity review patient's healthcare. We noticed prior the commencement this project that was not always being used in inpatient unit, with one four baseline data collection having no checks. despite clear guidance laid out trust policy 'Physical...
Background The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is the patient-reported outcome (PRO) that routinely used in clinical practice to monitor and measure disease activity axial spondyloarthropathy (axSpA). BASDAI scores greater than four are thought indicate active require better control. Magnetic resonance imaging (MRI) most objective of axSpA with its ability pick up inflammation both spine sacroiliac joints. Previous studies have shown conflicting correlations...
Cases of COVID-19 and associated hospitalizations are rising again, we at the start a "second wave". As prepare for second wave, must reflect on what have learned from first how going to effectively manage rheumatology patients forward. Rheumatology were thought be higher risk contracting due their disease immunosuppressive treatments. In March, British Society developed stratification tool identify who shield during height pandemic.1 Shielding precautions included staying home or within 2 m...
Abstract Introduction Immune checkpoint inhibitors (ICI) have revolutionised the treatment of solid tumours; however, due to their mechanism action, they are associated with various immune-related adverse events. Rheumatologists gaining experience in managing a variety ICI-induced inflammatory conditions, mainly rheumatoid arthritis, polymyalgia, and myositis, but given rarity these side effects all real time data is valuable. Eosinophilic fasciitis (EF) an uncommon condition symmetrical...
Abstract Background/Aims Nivolumab & ipilimumab are immune checkpoint inhibitors (ICIs) and combination therapy has shown efficacy in patients with malignant pleural mesothelioma. is a fully human IgG4 monoclonal antibody known as programmed cell death 1 (PD-1) inhibitor. The nivolumab features potentially synergistic mechanism of action that targets 2 different checkpoints (PD-1 CTLA-4) respectively. Myositis, an immune-related adverse event, been reported the literature. Ipilimumab...
Axial spondyloarthropathy (axSpA) is a heterogenous condition affecting the axial skeleton (Agrawal & Machado, 2020). The prevalence varies by ethnicity and higher in Caucasian population, this partly due to genetics especially HLA-B27 gene (Díaz-Peña et al., It not only that affected ethnicity, patient care also influenced ethnic factors multiple ways. Ethnicity can influence how patients perceive disease, as they may believe their rheumatological caused non-medical (Samanta 2012). Patient...
This editorial explores how technology has helped clinicians during the COVID-19 pandemic, from patient care to education, changes that have been made and numerous exciting possibilities of where can amalgamate with health care.
Nil conflicts. The authors have full control of all primary data and that they agree to allow the journal review their if requested.
Abstract Background/Aims Axial spondyloarthropathy (axSpA) is more prevalent in the Caucasian population. This part due to genetics; HLA-B27, main contributing gene, population, with up 90% of patients being positive. Incidence much lower Asian and Black There are few studies which have compared relationship between ethnicity severity axSpA. Existing show that, despite incidence actually suffer severe disease. However, there investigating With Leicester, UK such a diverse area, we took this...
Background The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a patient reported outcome (PRO) used in the monitoring of axial spondyloarthropathy (axSpA). It completed by and based on their assessment disease severity therefore quite subjective measure (1). There has been research around relationship between ethnicity perception Rheumatology. Many studies have demonstrated that non-Caucasian patients especially South Asians are less likely to engage with education, abandon...
Abstract Background/Aims Cauda equina syndrome is a rare but disabling neurological complication of axial spondyloarthropathy (axSpA) that occurs many years after disease onset, and often in the absence inflammatory symptoms. Its insidious onset long-standing axSpA means this condition can easily be missed, case report describes such an instance. Methods: Case An 82-year-old man diagnosed with HLA-B27 positive 1972 developed symptoms lumbar pain thigh 2012. He had nerve conduction studies...
Abstract Background/Aims The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is routinely used subjective outcome measurement of disease activity in (AS). BASDAI > 4 as a criterion for commencing anti-TNF therapy. Previous studies shown correlation with MRI has been proven to be weak. We did this study systemically compare clinical and radiological data patients AS look the degree between score changes positive spondyloarthritis our cohort patients. Methods A retrospective...
Abstract Background/Aims Due to the COVID-19 pandemic there have been changes NHS services limit unnecessary patient hospital visits and comply with new social restriction rules. One of these has introduction virtual consultations in outpatient clinics replace traditional face appointments. Methods A retrospective analysis feedback from adult appointments a 4-month period was collated reviewed (May-September 2020). After an appointment, patients were sent text message asking for feedback....