A5083203286- Osteoarthritis Treatment and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Inflammatory mediators and NSAID effects
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Trauma and Emergency Care Studies
- Global Health and Surgery
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Bone fractures and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Orthopedic Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Disaster Response and Management
- Orthopaedic implants and arthroplasty
- Trauma Management and Diagnosis
- Elbow and Forearm Trauma Treatment
- Gut microbiota and health
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Abdominal Trauma and Injuries
- Innovations in Medical Education
Memorial University of Newfoundland
2014-2024
Government of Newfoundland and Labrador
2022-2024
Health Sciences Centre
2014-2024
Christ University
2022
Eli Lilly (Singapore)
2022
Janssen (Switzerland)
2022
Merck (Japan)
2022
Novartis (Ireland)
2022
Novartis (Switzerland)
2022
Janssen (Italy)
2022
Objectives To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups. Design A case-only study design was utilised. Participants Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital Health Science Centre General John's, capital of Newfoundland Labrador (NL), Canada. 38 men 42 women included the study. The mean age 65.2±8.7 years....
Objective. To identify novel biomarker(s) for predicting advanced knee OA. Methods. Study participants were derived from the Newfoundland Osteoarthritis and Tasmania Older Adult Cohort Study. All OA cases patients who underwent total replacement (TKR) due to primary Metabolic profiling was performed on fasting plasma. Four thousand eighteen plasma metabolite ratios that highly correlated with in SF our previous study generated as surrogates joint metabolism. Results. The discovery cohort...
Objective. To investigate the relationship between plasma and synovial fluid (SF) metabolite concentrations in patients with osteoarthritis (OA). Methods. Blood SF samples were collected from primary knee OA undergoing total arthroplasty. Metabolic profiling was performed by electrospray ionization tandem mass spectrometry using AbsoluteIDQ kit. The yielded 168 concentrations. Correlation analysis done on absolute as well concentration ratios Spearman’s rank correlation (ρ) method. Results....
To identify endotypes of osteoarthritis (OA) by a metabolomics analysis.Study participants included hip/knee OA patients and controls. Fasting plasma samples were metabolomically profiled. Common factor analysis K-means clustering applied to the data patients. Logistic regression was utilized most significant metabolites contributing endotypes. Clinical epidemiological factors examined in relation identified endotypes.Six hundred fifteen primary 237 controls included. Among 186 measured, 162...
Obesity is a global pandemic, but there yet no effective measure to control it. Recent metabolomics studies have identified signature of altered amino acid profiles be associated with obesity, it unclear whether these findings actionable clinical potential. The aims this study were reveal the metabolic alterations obesity and explore potential strategies mitigate obesity. We performed targeted metabolomic profiling plasma/serum samples collected from six independent cohorts conducted an...
Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim of the study was to describethe genome wide DNA methylation changes hip and knee OA identify novel genes pathwaysinvolved by comparing methylome osteoarthritic cartilage tissues withthose OA-free individuals. Cartilage samples were collected from or joint replacement patients either due primary fractures as controls. extracted assayed Illumina Infinium HumanMethylation450 BeadChip array, which allows for analysis...
To test whether type 2 diabetic patients have an elevated level of advanced glycation end-products (AGEs) and responsible for altered phosphatidylcholine metabolism, which we recently found to be associated with osteoarthritis (OA) diabetes mellitus (DM), synovial fluid (SF) plasma samples were collected from OA without DM. Hyperglycemia-related AGEs including methylglyoxal (MG), free methylglyoxal-derived hydroimidazolone (MG-H1), protein bound N-(Carboxymethyl)lysine (CML)...
Classification systems for pelvic ring injuries have been developed to assist in understanding the anatomy of injury, predicting prognosis, and helping define treatment. Despite frequent clinical use Young-Burgess Tile classification systems, our knowledge little work has conducted validate either system. We assessed degree inter- intraobserver variability when using both thereby their validity use. Eighty-nine isolated disruptions were selected. Sets injury images randomly ordered...
Radiographic measurements to document ankle anatomy have been suggested in recent literature be inadequate. Focus has put on stress views and computed tomography; however, there are also issues with these modalities. An orthogonal view that could used both statically dynamically help determine syndesmotic stability. The purpose of this study was a parameter normal lateral radiograph will increase the reliability standard radiography diagnosing integrity.Three orthopedic surgeons reviewed 80...
Metabolomics studies use quantitative analyses of metabolites from body fluids or tissues in order to investigate a sequence cellular processes and biological systems response genetic environmental influences. This promises an immense potential for better understanding the pathogenesis complex diseases. Most conventional metabolomics analysis methods exam one metabolite at time may overlook synergistic effect combining multiple metabolites. In this article, we proposed new bioinformatics...
ABSTRACT Although total joint replacement (TJR) surgery is considered as the most effective treatment for advanced osteoarthritis (OA) patients, up to one‐third of patients reported unfavorable long‐term post‐operative pain outcomes. We aimed identify metabolic biomarkers predict non‐responders TJR using a metabolomics approach. were recruited and followed‐up at least 1‐year post‐surgery; outcomes assessed by Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) function...