A5043644071- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Tracheal and airway disorders
- Essential Oils and Antimicrobial Activity
- Parkinson's Disease Mechanisms and Treatments
- Tumors and Oncological Cases
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Nasolacrimal Duct Obstruction Treatments
- Parathyroid Disorders and Treatments
- Cardiac tumors and thrombi
- Pituitary Gland Disorders and Treatments
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging and Pathology Studies
- Obstructive Sleep Apnea Research
- Nasal Surgery and Airway Studies
- Thyroid Disorders and Treatments
- Biochemical and biochemical processes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Structural Anomalies and Repair
- RNA regulation and disease
- Infective Endocarditis Diagnosis and Management
- Head and Neck Cancer Studies
Noguchi Hospital
2022-2023
ENT and Allergy
2023
Kobe University
2011-2020
Kobe University Hospital
2019
Takatsuki General Hospital
1997
Objectives: A card-type odor identification test, Open Essence (OE), was recently developed in order to examine olfactory function the Japanese population. The purpose of this study validate efficacy new test by comparison with established examinations. Methods: We administered Jet Stream Olfactometry (JSO), an intravenous olfaction (Alinamin test), a visual analog scale symptoms dysfunction, and OE 50 patients complaints disturbance healthy volunteers. After results those existing...
Although spontaneous rupture of a cervical parathyroid adenoma with extracapsular hemorrhage is rare, it may cause and mediastinal hematoma, leading to potentially fatal consequences. The first case was 76-year-old Asian female who presented pharyngeal discomfort anterior chest ecchymosis. Endoscopic investigation showed submucosal in the pharynx larynx. second 62-year-old male ecchymosis suspected ruptured blood vessel. Both cases were diagnosed bleeding by hypercalcemia, high levels intact...
Background For olfaction, several studies have reported near-infrared spectroscopy (NIRS) signal changes in the orbitofrontal cortex (OFC) during odor stimulation. However, roles of human OFC olfactory cognition are less well understood. This study was designed to better understand for olfaction. Methods Hemodynamic responses phenyl ethyl alcohol or citral OFCs were measured with NIRS. After experiment, participants asked describe characteristics and rate intensity hedonic valence. Results...
ほかの感覚器と同様, 嗅覚も加齢性変化を来すことが知られている. しかし, 本邦では年齢を考慮した嗅覚機能の基準が報告されていない. 本研究では嗅覚同定能力研究用カードキットであるオープンエッセンス (Open Essence: OE) を用い, 嗅覚の加齢性変化の特徴を明らかにすることを目的とした.【方法】50歳以上の健常ボランティア50名と50歳未満の健常ボランティア43名に対し OE を施行し, 各嗅素別の正答率について検討を行った.【結果】50歳以上の群では男女とも年齢とともに の正答率の低下を認めた. 各嗅素別では50歳未満と50歳以上の2群間で墨汁, メントール, みかん, ばら, 練乳, にんにくの正答率に有意差を認めた. 12嗅素の組み合わせの中で, 練乳の3嗅素の組み合わせで50歳以上の嗅覚障害を検出する感度が0.860と最も高くなり, 感度+特異度が1.767となった. この3つの嗅素を組み合わせた検査が加齢性変化を考慮した嗅覚機能のスクリーニングとして有用であると考えられた.
Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which caused by deposition of Lewy bodies emerging from the bulb to higher centers. Early detection in patients PD may lead diagnosis and treatment for this refractory disease.Visual analog scale (VAS), Jet Stream Olfactometry, Japanese smell identification test, Open Essence (OE), were carried out on 39 PD. Thirty-one postviral (PVOD), was mucosal dysfunction, also enrolled study as control.There no...
In 2008, Kano developed a new laryngeal closure technique (Kano's method) for the treatment of severe aspiration. The aim this study was to evaluate safety and efficacy in patients with head neck cancer.Since June 2014 until March 2018, six underwent Kano's method management aspiration after cancers. anterior parts thyroid cricoid cartilages were excised widely. glottis closed by suturing bilateral vocal folds reinforced sternohyoid muscle. A tracheostoma created skin flaps, subglottic...
We report herein on a 71 year-old male who presented with olfactory disturbance at the early stage of Parkinson's disease (PD). Due to persistent for 5 years, patient visited our clinic and showed disorientation between detection threshold recognition in T&T olfactometry scored 3 out 12 points OE. During follow-up period, typical symptoms PD, including mask-like face motor emerged, which led diagnosis PD by neurologist. Since it is generally accepted that precedes appearance...
A weak point of intravenous olfactometry using Alinamin® (prosultiamine) solution is that angialgia and fluctuation in the pattern increase intranasal smell perception are frequently observed during test. previous study reported modified a 12-ml (6 × dilution by adding 10ml saline to original 10mg [2ml] prosultiamine solution) injected for 40 s helpful avoidance fluctuation. The present was conducted determine if generally useful many centers. total 143 normosmic subjects 15 centers...
Clear cell carcinoma (CCC) in the salivary gland is a rare malignant neoplasm and hardly located nasopharynx. An 18-year-old female presented with 3-year history of nasal congestion. Endoscopic examination revealed reddish round-shaped mass smooth surface posterior wall en bloc resection tumor was performed by endoscopic surgery. Preliminary pathological diagnosis made histopathological mucoepidermoid carcinoma. However, FISH analysis for MAML2-split negative but that EWSR1-split positive....
嗅覚同定検査にスティック型嗅覚検査法(OSIT-J)とオープンエッセンス(OE)がある。これらは検査手順が異なるが,同じ12嗅素で構成されており,近年,広く臨床研究に利用されるようになってきた。今回,我々はこの二つの検査に一致性があるかを検討した。嗅覚正常と自覚している20歳以上40歳未満の男女各10名,全20例の健常ボランティアを対象とし1群は初回にOSIT-J,2週間後にOEを施行し,2群は逆の順で検査を行った。結果:ボランティアの平均年齢32.1歳,男性32.7歳,女性31.4歳で男女間に有意差は認めなかった(P=0.56)。OSIT-Jの平均値は11.0(中央値11.0,95%CI:10.6~11.6),OEは10.7(中央値11.0,95%CI:10.1~11.2)で,両検査平均値,中央値ともに95%CIに含まれた。嗅素別の正答率は12嗅素中,カレーのみ両検査ともに100%であった。同一被検者において,両検査間の同定(正答)・非同定(誤答)嗅素の一致率は,同定(正答)で100%一致した症例は5/20例,非同定(誤答)では1/16例であった。以上の結果より,2検査間でスコ...
COVID-19 嗅覚障害は従来の感冒後嗅覚障害とは異なる臨床像を呈することが判明してきた. その一つに CT 画像上での嗅裂所見がある. われわれは, 画像での嗅裂所見に注目し, 臨床研究を行った. 対象96症例に対し, 上の嗅裂の閉塞なし, ありの2群に分けて, 年齢, 性別, と診断され, 嗅覚障害を自覚した日から受診までの日数 (以下, 発症から受診までの日数), 異嗅症の有無, 嗅覚障害程度について調査した. 嗅覚検査は Visual analogue scale (VAS), 日常のにおいのアンケート, 基準嗅力検査, 静脈性嗅覚検査 (アリナミンテスト), スティック型嗅覚検査 (odor stick identification test for Japanese: OSIT-J) を行った. さらに, 経過を追えた23例に対し, 嗅覚障害改善の予測因子について探索した. での嗅裂閉塞あり群の症例では閉塞なし群より嗅覚障害の程度は高度であった. 治癒までの経過を追えた23症例で, 発症から受診までの日数が予後の予測因子となった. 嗅裂の閉塞所見を認める症例では,...
Chronic granulomatous disease (CGD) is one of the congenital immune deficiency diseases in which bacteriocidal function neutrophils missing. Even though prevalenecs CGD low among various hereditary diseases, it highest phagocyte disorders. The pathognomonic symptoms this include recurrent infection and foci begin infancy. Pneumonia most prevalent clinical symptom, while otorhinological tend to berare. We examined a child who was referred our hospital with left acute otitis media. Because...