A5100325926- Antibiotic Resistance in Bacteria
- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Phenothiazines and Benzothiazines Synthesis and Activities
- Proteins in Food Systems
- Protein Hydrolysis and Bioactive Peptides
- Single-cell and spatial transcriptomics
- Synthesis and biological activity
- Pneumocystis jirovecii pneumonia detection and treatment
- Gene expression and cancer classification
- Plant Physiology and Cultivation Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Genetic Mapping and Diversity in Plants and Animals
- Polyamine Metabolism and Applications
- Conducting polymers and applications
- Chemical Synthesis and Analysis
- Postharvest Quality and Shelf Life Management
- Trace Elements in Health
- Meat and Animal Product Quality
- Free Radicals and Antioxidants
- Metabolomics and Mass Spectrometry Studies
- Microbial Metabolites in Food Biotechnology
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- RNA modifications and cancer
Chongqing University
2017-2025
South China Agricultural University
2022-2025
Institute of Special Animal and Plant Sciences
2024-2025
Chinese Academy of Agricultural Sciences
2024-2025
Yale University
2025
Henan Institute of Science and Technology
2015-2024
Fujian Medical University
2024
Xi’an International University
2024
China XD Group (China)
2024
Zhejiang University
2022-2024
Abstract Size selectivity is an important mechanism for molecular recognition based on the size difference between targets and non-targets. However, rational design of artificial size-selective system biological in living cells remains challenging. Herein, we construct a DNA sieve to improve biosensing cells. The consists functional nucleic acid probes (e.g., DNAzymes, aptamers beacons) encapsulated into inner cavity framework acid. Thus, small target molecules are able enter efficient...
The nutritional value and flavor texture characteristics of fruits from different Actinidia argute resources were scientifically evaluated compared. Using 35 A. arguta as materials, the amino acid composition content determined by an automatic analyzer, differentiation analysis, evaluation, TAV correlation PCA comprehensive cluster analysis conducted to clarify diversity in terms content, composition, characteristics. Analysis differential results showed that resource contained 17 acids with...
Fermented milks with strong angiotensin I-converting enzyme (ACE)-inhibitory activity were obtained through a culture Lactobacillus helveticus KLDS.31 and casei KLDS.105 fermentation storage temperature of 37 °C. Ultrafiltration fractions molecular weight less than 3 kDa in fermented milk whey exhibited the strongest inhibitory activity. Correspondingly, gastrointestinal digestion experiment showed retention bioactivity these pepsin trypsin treatment. Four ACE-inhibitory peptides from...
Throughout the world, wind energy is widely distributed as one of most universal sources in nature, containing a gigantic reserve renewable and green energy. At present, main way to capture use an electromagnetic generator (EMG), but this technology has many limitations; notably, conversion efficiency relatively low irregular environments or when there only gentle breeze. A triboelectric nanogenerator (TENG), which based on coupling effect triboelectrification electrostatic induction,...
We report a promising NDM-1 inhibitor, disulfiram, which can covalently bind to by forming an S–S bond with the Cys208 residue. Cu(DTC)<sub>2</sub> also inactivated through oxidizing Zn(<sc>ii</sc>) thiolate site of enzyme.
The emergence and prevalence of carbapenem-resistant bacterial infection have seriously threatened the clinical use almost all β-lactam antibacterials. development effective metallo-β-lactamase (MβL) inhibitors to restore existing antibiotics efficacy is an ideal alternative. Although several types serine-β-lactamase been successfully developed used in settings, MβL are not clinically available date. Herein, we identified that cisplatin Pd(II) complexes potent broad-spectrum B1 B2 subclasses...
The effects of different shaping methods and loading treatments on the photosynthetic rate, chlorophyll content, fruit yield quality, volatile compound composition 'Beibinghong' grape were studied. In experiment, 6-year-old grapes selected as material, two kinds adopted: double main vine upright tree (control) inclined horizontal dragon tree. was treated with loads. components in analyzed by gas chromatography-mass spectrometry (GC-MS). changes quality under multivariate statistics. results...
Keywords: vascular endothelial growth factor A, bevacizumab, antiangiogenesis, direct antitumor activity, tumor cells
It's important to dissect the relationship between copy number variations (CNVs) and DNA methylation, because both greatly change dosages of genes are responsible for diverse human cancers. Although whole genome bisulfite sequencing (WGBS) informs CNVs no study has provided a systematic benchmark detecting from WGBS data. Herein, based on simulated real datasets 84.62 billion reads, we undertook 714 CNV detections comprehensively performance 35 strategies, 5 alignment algorithms (bismarkbt2,...