A5068326550- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Systemic Lupus Erythematosus Research
- Neonatal Health and Biochemistry
- Lymphatic System and Diseases
- Orthopedic Infections and Treatments
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
- Chemokine receptors and signaling
- Maternal and Perinatal Health Interventions
- IgG4-Related and Inflammatory Diseases
- Immune cells in cancer
- Diabetes and associated disorders
- Genetic and rare skin diseases.
- Atherosclerosis and Cardiovascular Diseases
- Ocular Disorders and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Congenital Anomalies and Fetal Surgery
- Inflammasome and immune disorders
University of Missouri–Kansas City
2017-2025
Children's Mercy Hospital
2016-2025
University of Kansas Medical Center
2021
University Medical Center
2021
University Hospital and Clinics
2021
Perinatal Institute
2020
Sisters of Mercy Health System
2019
The University of Texas Southwestern Medical Center
2006-2007
To describe the survival rate, timing of liberation from ventilator, and factors favorable for decannulation among infants with severe bronchopulmonary dysplasia (sBPD) who received tracheostomy.Demographics clinical outcomes were obtained through retrospective chart review 98 sBPD born between 2004 2017, tracheostomy at <1 year age, followed in Infant Tracheostomy Home Ventilator clinic up to 4 years age.The number increased significantly over study period. The median age was months (IQR 3,...
Rationale: Invasive aspergillosis is a severe fungal infection afflicting immunocompromised patients, particularly patients with neutrophil defects. CCR6, β-chemokine receptor, mediates migration of dendritic cells (DCs) and several lymphocyte subsets to sites epithelial inflammation, but its role in infections has not been examined extensively.Objectives: To test the hypothesis that CCR6-mediated leukocyte recruitment necessary for effective host defense neutropenic hosts invasive pulmonary...
Background: Utilization of the neonatal sepsis calculator published by Kaiser Permanente is rapidly increasing. This freely available online tool can be used in assessment early-onset (EOS) newborns 34 weeks' gestation or more based on maternal risk factors and examination. However, many hospitals lack standard guidelines for its use, leading to provider discomfort with practice change. Purpose: The goal this project was study antibiotic use rate EOS at a level III intensive care unit create...
To compare the accuracy of three newly proposed definitions bronchopulmonary dysplasia (BPD) in predicting outcomes, and to investigate impact large airway vs. parenchymal vascular BPD phenotypes on outcomes. Retrospective chart review 100 infants with severe discharged from a Children's hospital between 2020-2021. Multivariable models evaluated associations tracheostomy death at 6 months 1 year after NICU discharge. Secondary outcomes included need respiratory support, use pulmonary...
ABSTRACT Objectives To characterize an observational cohort of ventilator‐dependent infants and children with bronchopulmonary dysplasia (BPD) or without tracheobronchomalacia (TBM) determine the impact TBM on need for ventilator support, liberation from tracheostomy decannulation. Methods Demographics clinical outcomes were obtained by retrospective review 12 centers participating in outpatient BPD Collaborative registry. The consisted born between 2016 2021 who dependent invasive...
Abstract The genetic predisposition to many autoimmune diseases is inherited as a polygenic trait. It conceivable that some of the causative alleles in these became prevalent population by conferring survival benefit against environmental assaults, such infections. We used mice cogenic for loci predisposing systemic lupus erythomatosus test hypothesis protect host from bacterial Mice with Sle3 lupus-susceptibility locus on wild-type background were found have enhanced antibacterial responses...
This article aimed to identify readmission risk factors through 2 years of life for infants with severe bronchopulmonary dysplasia (BPD) who do not require tracheostomy and ventilatory support after neonatal intensive care unit (NICU) discharge. It also if clinical differences exist between the subcategories BPD.A retrospective chart review was performed on 182 BPD born 2010 2015. A total 130 met inclusion criteria were stratified into three groups based their respiratory status at 36 weeks...
Abstract Background Bronchopulmonary dysplasia (BPD), a common complication of prematurity, is associated with outpatient morbidities, including respiratory exacerbations. Daycare attendance increased rates acute and chronic morbidities in children BPD. We sought to determine if additional the household conferred similar risks for Methods The number clinical outcomes were obtained via validated instruments 933 subjects recruited from 13 BPD specialty clinics United States. Clustered logistic...
Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes gamut of liver and systemic diseases. We present unique case neonatal in premature infant with born to mother hypothyroidism during pregnancy remote history disease. Infant was treated combination methimazole, propranolol, potassium iodide for 4 weeks. Thyroid function improved after 8 weeks treatment full recovery thyroid function, disappearance...
Abstract We describe a girl infant with anomalies of the left pelvis and lower limb (pelvic, femoral, tibial hypogenesis absent fibula), subtle facial changes, patent foraman ovale, single umbilical artery, kidney, imperforate anus. The external genitalia were asymmetric ambiguous normal uterus ovaries visualized by ultrasound. are compatible previously reported cases Al‐Awadi/Raas‐Rothschild/Schinzel (AARRS) phocomelia, an autosomal recessive disorder WNT7 gene mutations documented in one...
This case report highlights the importance of screening for mutations in EPHB4 and other genes that regulate lymphatic development infants with nonimmune hydrops fetalis.
Abstract Objective : To compare the accuracy of three newly proposed definitions bronchopulmonary dysplasia (BPD) in predicting outcomes, and to assess impact BPD phenotypes (large airway vs. parenchymal vascular disease) on outcomes. Study Design Retrospective chart review 100 infants with severe discharged from a Children’s hospital between 2020-2021. Multivariable models evaluated associations tracheostomy death. Result Jensen’s collaborative criteria best predicted outcomes associated...
Background: CDC guidelines for EOS evaluation based on maternal risk factors are not clear and leads to increased laboratory workup initiation of antibiotics. Increased antibiotics use separation mother the baby, decreases breast feeding rates, increases antibiotic resistance ultimately health care costs. Neonatal sepsis calculator published by Kaiser Permanente group a large multicenter study is being used at several Intensive Care Units (NICU) nationwide. This freely available online tool...