A5047604769- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Gout, Hyperuricemia, Uric Acid
- Intraocular Surgery and Lenses
- Peroxisome Proliferator-Activated Receptors
- Renin-Angiotensin System Studies
- Advanced Glycation End Products research
- RNA modifications and cancer
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Retinal and Macular Surgery
Shanghai Eye Disease Prevention & Treatment Center
2021-2023
Shanghai Jiao Tong University
2018-2023
Shanghai First People's Hospital
2018-2023
National Clinical Research
2021
Endothelial dysfunction is a critical and initiating factor of the vascular complications diabetes. Inflammation plays an important role in endothelial regulated by epigenetic modifications. N6-methyladenosine (m6A) one most prevalent modifications eukaryotic cells. In this research, we identified m6A demethylase, fat mass obesity-associated protein (FTO), as essential epitranscriptomic regulator diabetes-induced dysfunction. We showed that enhanced FTO reduced global level hyperglycemia....
To investigate the association between serum uric acid (SUA) levels and vision-threatening diabetic retinopathy (VTDR) in patients with type 2 diabetes.This cross-sectional study evaluated 3481 diabetes from four communities China 2016 2019. VTDR was defined as severe nonproliferative, proliferative retinopathy, or clinically significant macular edema by fundus photography optical coherence tomography. Potential SUA examined using multivariable logistic regression. Sub-group analyses based...
Purpose . To examine the difference in vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) and without preoperative intravitreal conbercept (IVC) treatment. Methods Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine vitreous humor PDR treated (IVC group;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>) (PDR...
ObjectiveAn elevated serum calcium level is associated with a higher risk of type 2 diabetes (T2D), but its role in microvascular complications remains unclear. This study was conducted to investigate the association between levels and vision-threatening diabetic retinopathy (VTDR).MethodsThis employed cross-sectional longitudinal design. The part included all patients treated for T2D at Shanghai General Hospital 2007 2016, while involved an overlapping cohort without VTDR who were followed...
Abstract Background To investigate the prevalence and predictors of retinal breaks reopening after vitrectomy with air tamponade in rhegmatogenous detachment (RRD). Methods A retrospective cohort study was conducted Shanghai General Hospital. Chart review performed among 1715 patients primary RRD who received pars plana (PPV) as initial management. Patients were followed up for recurrence. The clinical features eyes recorded. Logistic regression constructed to reopening. Results total 137...
Proliferative diabetic retinopathy (PDR) accounts for severe impact on vision, its mechanism is still poorly understood. To compare the differences of vitreous protein profiles in PDR patients before and after a complete anti-vascular endothelial growth factor (VEGF) loading dose with ranibizumab treatment. Twelve humor (VH) samples were collected from six (set as pre group) post intravitreal injection (IVR) LC-MS/MS bioinformatics analysis performed to identify differentially expressed...
Uric acid (UA) is the final product of human purine metabolism. As one main antioxidants in body, it can scavenge oxidative radicals. Under action oxidative-antioxidant shuttle mechanism, antioxidant activity UA be reversed, causing inflammation and stress vascular endothelial cells. Hyperuricemia (HUA) considered to major risk factors for diabetes diabetic nephropathy. The study HUA retinopathy (DR) also a hot topic. cause retinal sclerosis, affect occurrence development DR by promoting...