A5102716692- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Advanced Data Storage Technologies
- Parallel Computing and Optimization Techniques
- Advanced Glycation End Products research
- Intraocular Surgery and Lenses
- Cloud Computing and Resource Management
- Peroxisome Proliferator-Activated Receptors
- Retinal and Macular Surgery
- Lipid metabolism and disorders
- Corneal surgery and disorders
- Low-power high-performance VLSI design
- Ocular Infections and Treatments
- Inflammasome and immune disorders
- Distributed and Parallel Computing Systems
- Retinal and Optic Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ferroptosis and cancer prognosis
- Optical Coherence Tomography Applications
- Semiconductor materials and devices
- Calpain Protease Function and Regulation
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Aldose Reductase and Taurine
- Liver physiology and pathology
Eye & ENT Hospital of Fudan University
2019-2025
Google (United States)
2024
Bellevue Hospital Center
2024
Shuguang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
University of Chicago
2017-2022
Shanghai First People's Hospital
2016-2019
Shanghai Jiao Tong University
2015-2019
Fudan University
2015-2017
Purpose: To elucidate the mechanism whereby miR-590-3p regulates pyroptosis in diabetic retinopathy (DR). Methods: Human retinal microvascular endothelial cells (HRMECs) incubated with high glucose (HG) were used to establish cell models, and expression levels of miR-590-3p, caspase-1, IL-1β, NLRP1, NOX4, TXNIP, NLRP3, ROS determined. Additionally, was altered using a mimic or an inhibitor, siRNAs targeting NLRP1 NOX4 applied explore regulatory DR. The relationships between NLRP1/NOX4 also...
Abstract Sesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been shown to have potential anticancer activities. This study aims at characterizing the antitumor efficacy of sesamol and unveiling importance mitochondria sesamol-induced effects using human hepatocellular carcinoma cell line, HepG2 cells. Results this showed that treatment suppressed colony formation, elicited S phase arrest during cycle progression, induced both intrinsic extrinsic apoptotic...
Abstract Background Angiogenesis is an important parameter in the development of diabetic retinopathy (DR), and it indicative early stage evolving into a late phase. Therefore, examining role angiogenic factors DR crucial to understanding mechanism neovascularization. Methods The present study identified hub genes pathways associated with angiogenesis using bioinformatics analysis. Genes from published literature Gene Expression Omnibus (GEO) were collected analysed. Results We 73 70 studies...
This hospital-based, cross-sectional study investigated the effect of age diabetes onset on development diabetic retinopathy (DR) among Chinese type 2 mellitus (DM) patients. A total 5,214 patients with DM who were referred to Department Ophthalmology at Shanghai First People's Hospital from 2009 2013 was eligible for inclusion. Diabetic status classified using grading system Early Treatment Retinopathy Study (ETDRS). Logistic and hierarchical regression analyses used identify independent...
Big data analytic applications give rise to large-scale extract-transform-load (ETL) as a fundamental step transform new into native representation. ETL workloads pose significant performance challenges on conventional architectures, so we propose the design of unstructured processor (UDP), software programmable accelerator that includes multi-way dispatch, variable-size symbol support, Flexible-source dispatch (stream buffer and scalar registers), memory addressing accelerate kernels both...
The Ba-Qi-Rougan formula (BQRGF) is a traditional and effective compound prescription from Traditional Chinese Medicine (TCM) utilized in treating hepatic fibrosis (HF).
Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism not fully understood. The objective this research to observe change protein profile induced by ranibizumab (an anti-VEGF agent) vitreous humor from PDR patients and reveal effects on PDR.A proteomic method was identify differentially expressed proteins humor. Untreated were defined as group, while those who treated with...
Purpose: To study the imaging findings of ultrawide-field swept source optical coherence tomography angiography (ss-OCTA) and its advantages with respect to fundus photography (FP) in precise diagnosis diabetic retinopathy (DR), reveal applications DR. Methods: The microangiopathy ss-OCTA FP from DR patients were retrospectively analyzed, differences between two methods assessed. In addition, grade based on modalities was determined compared. Results: Ultra-widefield clearly revealed various...
Purpose: Fenofibrate has been demonstrated to exert a promising therapeutic effect against diabetic retinopathy. Angiopoietin-like 3 (ANGPTL3) shown significant pathogenic effects on vascular endothelial cells, which are critically involved in the pathogenesis of The present study aimed investigate link between fenofibrate and ANGPTL3 Methods: Diabetic control rats were randomly assigned following treatments: intravitreal injection with small interfering RNA (siRNA), recombinant human...
The data science revolution and growing popularity of lakes make efficient processing raw increasingly important. To address this, we propose the ACCelerated Operators for Raw Data Analysis (ACCORDA) architecture. By extending operator interface (subtype with encoding) employing a uniform runtime worker model, ACCORDA integrates transformation acceleration seamlessly, enabling new class encoding optimizations robust high-performance processing. Together, these key features preserve software...
Purpose . To examine the difference in vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) and without preoperative intravitreal conbercept (IVC) treatment. Methods Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine vitreous humor PDR treated (IVC group;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>) (PDR...
Recently, much attention has been paid to approximate computing, a novel design paradigm for error-tolerant applications. It can significantly reduce area, power, and delay of circuits by introducing an acceptable amount error. In this paper, we propose new heuristic method two-level logic synthesis. The problem is identify sum-of-product (SOP) expression under given error rate (ER) constraint so that it the fewest literals. basic idea our find optimal set input combinations 0-to-1 output...
Computational storage adds computing to devices, providing potential benefits in offload, data-reduction, and lower energy. Successful computational SSD architectures should match growing flash bandwidth, which turn requires high DRAM memory bandwidth. This creates a wall scaling problem, resulting from SSDs' stringent power cost constraints.A survey of recent research shows that many offloads are suited stream computing. To exploit this opportunity, we propose novel general-purpose core...
Approximate circuit design is an emerging paradigm in which a designer deliberately changes the specified Boolean function to reduce area, delay, and/or power consumption of circuit. This paper focuses on synthesis approximate logic circuits (or ALS) under given error constraint. In particular, we consider ALS for two-level rate A dynamic programming-based algorithm proposed find nearly optimal by identifying most promising set cubes be added on-set original function. Then, off-the-shelf...
Proliferative diabetic retinopathy (PDR) accounts for severe impact on vision, its mechanism is still poorly understood. To compare the differences of vitreous protein profiles in PDR patients before and after a complete anti-vascular endothelial growth factor (VEGF) loading dose with ranibizumab treatment. Twelve humor (VH) samples were collected from six (set as pre group) post intravitreal injection (IVR) LC-MS/MS bioinformatics analysis performed to identify differentially expressed...
<b><i>Introduction:</i></b> We characterized the role of aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) in retinal inflammation and apoptosis regulation, both vivo vitro. In addition, we used clinical specimens to show relationship between AIMP1 development diabetic retinopathy (DR). <b><i>Objective:</i></b> To elucidate DR. <b><i>Methods:</i></b> A AIMP1-specific knockout (KO) C57 mouse model...
Shuffle is an indispensable process in distributed online analytical processing systems to enable task-level parallelism exploitation via multiple nodes. As a data-intensive data reorganization process, shuffle implemented on general-purpose CPUs not only incurs traffic back and forth between the computing storage resources, but also pollutes cache hierarchy with almost zero reuse. result, can easily become bottleneck of analysis pipelines.Our PSACS approach attacks these bottlenecks rising...