A5102828693- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Medical Imaging Techniques and Applications
- Click Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- Synthesis and biological activity
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Birth, Development, and Health
- vaccines and immunoinformatics approaches
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
Taizhou Fourth People's Hospital
2021-2025
Kunming Medical University
2024-2025
Tongji University
2022-2025
Peking University
2025
Peking University Cancer Hospital
2025
Affiliated Hospital of Qingdao University
2023-2024
Qingdao University
2023-2024
Jilin University
2009-2023
China Pharmaceutical University
2020-2023
Union Hospital
2015-2023
Purpose: Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the overall biological roles and clinical significance most lncRNAs gastric carcinogenesis are not fully understood. We investigated significance, function, mechanism LINC01234 cancer.Experimental Design: First, we analyzed alterations cancerous noncancerous tissues through an analysis sequencing data obtained from The Cancer Genome Atlas. Next, evaluated...
Abstract Background Immunotherapy has revolutionized cancer treatment. Recent studies have suggested that the efficacy of immunotherapy can be further enhanced by influence gut microbiota. In this study, we aimed to investigate impact bacteria on effectiveness combining analysis clinical samples with validation in animal models. Methods order characterize diversity and composition microbiota its relationship response immune checkpoint inhibitors (ICIs), 16S ribosomal RNA (rRNA) GC–MS...
Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such cell proliferation, apoptosis, migration, and invasion. LINC00152 is located on chromosome 2p11.2, has length 828 nucleotides. The biological role in LAD(lung adenocarcinoma) remains unknown.Quantitative reverse transcription PCR(qRT-PCR) was used to detect expression 60 human LAD tissues paired normal tissues. In vitro vivo showed the function tumour...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib, have been established first-line treatments for non-small cell lung cancer (NSCLC) patients and exhibited notable clinical efficacy. However, resistance to TKIs has become one of the major obstacles in improving therapeutic efficacy with NSCLC. This study aims investigate role long non-coding RNA (lncRNA) LINC01116 gefitinib NSCLC explore its underlying mechanism. In this study, we found that is...
5-Fluorouracil (5-Fu) is a widely applied anti-cancer agent against colorectal cancer (CRC), yet number of CRC patients have developed resistance to 5-Fu-based chemotherapy. The epidermal growth factor receptor (EGFR) recognized as an oncogene that promotes diverse progresses. In addition, long noncoding RNAs (lncRNAs) are essential regulators cancers. Here we report EGFR and lncRNA-FGD5-AS1 promoted 5-Fu CRC. By establishing the 5-Fu-resistant cell line, detected EGFR, FGD5-AS1, glucose...
Radiotherapy (RT) is commonly used to treat multi-tumors attenuate the risk of recurrence. Despite impressive initial clinical responses, a large proportion patients experience resistance RT. Therefore, identification functionally relevant biomarkers would be beneficial for radioresistant patients. Adenosine monophosphate-activated kinase (AMPK) recognized as mediator tumor suppressor gene function. In present study, radio-sensitive and -resistant colon cancer patient samples were compared...
Metastasis associated 1 protein (MTA1) is one of the prime facilitators metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, underlying regulatory mechanism MTA1 expression HCC not clear. In this study, we evaluated transcript and normal hepatic cell lines. The results revealed that had a significantly increase line, HuH6, compared with THLE-2. Determination half-life using cycloheximide (CHX) treatment did reveal any statistically significant...
To reveal the natural correlation between prostate-specific membrane antigen (PSMA) imaging and tumor neovascularization in prostate cancer further explore E-urea-K-based PSMA-targeted (EK-PSMA) as a potential indicator of neovascularization, 22Rv1 mouse models were established underwent 99mTc-HYNIC-ALUG SPECT/CT. Pearson analysis was applied to assess relationship tracer uptake characteristics, including size, glucose metabolism, cell phenotypes (e.g., Ki-67, VEGF, CD31, PSMA). Then,...
To investigate the clinicopathological factors influencing lung and bone metastasis in breast cancer, to further construct a nomogram model for predicting risk of cancer patients at various time points, followed by prognostic analysis. The retrospective analysis included 200 with among whom 51 had metastases 57 metastases. remaining 92 without served as control group. Baseline characteristics were analyzed using chi-square test; COX univariate multivariate analyses applied explore factors. A...
ErbB2 is known to upregulate glycolysis in breast cancer, however, the precise mechanisms remain unclear. In present study, upregulated Hexokinase II (HK II) activity by increasing binding of HK mitochondrial outer membrane. Dysregulated glucose metabolism high ErbB2‑expressing cancer cells induces susceptibility starvation and inhibition. Additionally, has a tendency dissociate from mitochondria membrane ErbB2‑overexpressing following treatment with inhibitor, 3‑BrPA. Furthermore, 3-BrPA...
Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),is the currently recommended first-line therapy for advanced EGFR-mutant lung cancer, and understanding mechanism of resistance is key to formulating therapeutic strategies EGFR-TKIs. In this study, we evaluate expression patterns potential biological functions pseudogene DUXAP10 in gefitinib resistance. We find that significantly upregulated NSCLC gefitinib-resistant cells tissues. Gain loss function assays...