Abstract Background Immunotherapy has revolutionized cancer treatment. Recent studies have suggested that the efficacy of immunotherapy can be further enhanced by influence gut microbiota. In this study, we aimed to investigate impact bacteria on effectiveness combining analysis clinical samples with validation in animal models. Methods order characterize diversity and composition microbiota its relationship response immune checkpoint inhibitors (ICIs), 16S ribosomal RNA (rRNA) GC–MS...

Growing evidence indicates that gut microbiota is involved in the regulation of host's sex hormone levels, such as through interfering with metabolism intestine. However, if or its metabolites directly influence biosynthesis gonad remains largely unknown. Our previous study showed colistin, a narrow-spectrum antibiotic, can significantly downregulate serum testosterone levels and thus enhance antitumor efficiency anti-PD-L1 male mice; however, underlying mechanism for uninvestigated. In...

Accumulating evidence has revealed that the dysregulation of circular RNAs (circRNAs) plays crucial roles in occurrence and progression cancers. However, aberrant expression profile dysfunction circRNAs non-small cell lung cancer (NSCLC) have not been fully explored. Herein, we discovered a circRNA, hsa_circ_0001666 (circ0001666), was highly expressed NSCLC tissues lines, it positively correlated with tumor pathological grade lymph node metastasis. Moreover, Kaplan-Meier survival analysis...

The efficacy of prophylactic cranial irradiation (PCI) is still controversial in small cell lung cancer (SCLC) patients with pT1-2N0M0 disease after complete resection. majority previous studies haven't discerned the potential benefit PCI this subgroup patients, probably due to paucity these and distinct treating modalities. aim study demonstrate medical patients. A retrospective was conducted evaluate SCLC We retrospectively reviewed 112 SCLCs resection adjuvant chemotherapy between January...

Coarctation of the aorta (CoA) is a common congenital cardiovascular malformation, and improvements in diagnostic process for surgical decision-making are important. We sought to compare accuracy transthoracic echocardiography (TTE) with computed tomographic angiography (CTA) diagnose CoA.We retrospectively reviewed 197 cases CoA diagnosed by TTE CTA confirmed at surgery from July 2009 August 2019.The findings that 19 patients (9.6%) had isolated 178 (90.4%) combined other malformations. The...

The long‑term prognosis for patients with gastric cancer (GC) following radical resection remains poor. It is important to identify prognostic markers predict survival. In the present retrospective study, association between metastatic lymph node ratio (rN) and Lauren classification on predicting overall survival (OS) was investigated. Furthermore, a subgroup analysis performed classification, using rN score as an independent marker. total, 261 pathologically confirmed GC were...

Until recently, few cases of three or more malignant tumors in one patient have been reported. Owing to the high incidence rate these tumors, improvement cancer diagnosis and treatment, extension survival time, reported multiple primary neoplasms has gradually increased. The present study case a 57‑year‑old man with non‑small cell lung combined B‑Raf proto‑oncogene serine/threonine kinase V600E mutation, gastrointestinal stromal lumbar vertebral mucinous sarcoma. pathogenesis, treatment...

Background: Previous experimental studies have established that MicroRNAs (miRNAs) can function as oncogenes or tumor suppressors in the regulation of biology pathology. However, effects ionizing radiation (IR) on expression levels cellular miRNAs and their further biological behavior cells require investigation. Methods: We determined proliferation, migration tube formation HUVEC after (control, 0h 24h), changes miR-21, VEFG HIF-1α were measured by Western blot (WB). The miR-21 mimics...

Although the prognostic value of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR) and lymphocyte/white blood cell (LWR) has been described in advanced non-small lung cancer (NSCLC), association between complete parameters prior to disease treatment NSCLC have yet be identified. The aim present study was assess patients with NSCLC. A total 268 were enrolled this study. Clinical laboratory data acquired through medical records. Receiver operating characteristic curve analysis used...

The gut microbiota and its associated metabolites play a critical role in shaping the systemic immune response influencing efficacy of immunotherapy. In this study, patients with extensive-stage small cell lung cancer (ES-SCLC) were included to explore correlation between immunotherapy ES-SCLC. Pre- post-treatment, we collected stool samples from 49 ES-SCLC treated an anti-programmed death-ligand 1 (PD-L1) antibody. We then applied 16S ribosomal RNA (rRNA) sequencing liquid...

Abstract Background Nuclear factor‐κB p65 (NF‐κB p65) may play a significant role as biomarker in tumor progression and metastasis. However, the correlation between cellular localization of NF‐κB expression prognosis gastric cancer (GC) patients has not been studied. The present study was designed to investigate location GC, evaluate its with clinicopathological parameters GC patients. Methods expressions tissue corresponding nonmalignant from gastrectomy 115 stage I–III were detected by...

e13590 Background: Immunotherapy is becoming one of the promising treatments for cancer administration, and several studies indicated a better outcome was received in patients with high tumor mutation burden (TMB). The distribution TMB still unknown this study aimed to analysis association between age especially East Asian populations. Methods: In our study, value measured as numbers synonymous, nonsynonymous mutations InDels by next generation sequencing 539 genes panel tissue. TMB-H...

Abstract To explore a better treatment strategy for patients with advanced non‐small cell lung cancer harboring sensitive epidermal growth factor receptor mutations, total of 271 were retrospectively analyzed. The divided into two groups: the combination group (58 cases), which received concurrent icotinib, pemetrexed, and platinum treatment, sequential (213 pemetrexed therapy, followed by icotinib treatment. primary end points progression‐free survival (PFS) PFS on subsequent line therapy...

This study aimed to explore the safety and efficacy of simultaneous interventional therapy for compound congenital heart disease (CCHD) in children.In total, 155 children with CCHD who received at Children's Hospital Chongqing Medical University between January 2007 December 2021 were included study. Data on clinical manifestations, transthoracic echocardiography, electrocardiogram, follow-up retrospectively analyzed.The most common type was atrial septal defect (ASD) combined ventricular...

Abstract This study explored the value of routine transthoracic echocardiography (TTE) combined with two‐dimensional speckle tracking (2D‐STE) for early evaluation left ventricular remodeling in hypertensive immature rabbit model. Twenty‐seven New Zealand white rabbits were divided into Group A (sham‐operated group), B (mild and C (severe 9 per group. The hypertension model was constructed using “two kidneys one clip” method. Changes function degree wall thickening observed by TTE at 1, 4, 8...