A5101521333- Antimicrobial agents and applications
- Inhalation and Respiratory Drug Delivery
- Plant Stress Responses and Tolerance
- Plant Virus Research Studies
- Plant Molecular Biology Research
- Fluorine in Organic Chemistry
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Plant nutrient uptake and metabolism
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- Parasite Biology and Host Interactions
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Mollusks and Parasites Studies
- Soil Management and Crop Yield
- Antimicrobial Peptides and Activities
- Biochemical and biochemical processes
- Magnetic and Electromagnetic Effects
- Plant-Microbe Interactions and Immunity
- Plant Micronutrient Interactions and Effects
- Ichthyology and Marine Biology
- Immunotherapy and Immune Responses
Ningxia University
2023-2025
Center for Life Sciences
2023-2024
Tsinghua University
2024
State Key Laboratory of Membrane Biology
2024
Ningxia Academy of Agriculture and Forestry Sciences
2023
Chinese Academy of Sciences
2013-2022
Microbiology Institute of Shaanxi
2019-2022
Institute of Microbiology
2019-2022
Gansu Agricultural University
2022
University of Chinese Academy of Sciences
2019-2021
Abstract DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate cGAS-STING (cyclic GMP-AMP synthase—stimulator interferon genes) pathway in antigen-presenting (APCs) and promote antitumor immunity. However, conventional chemotherapy displays limited cell killing ineffective transfer stable to APCs. Here we show liposomes loaded with an optimized ratio indocyanine green doxorubicin, denoted as LID, efficiently...
Ca2+ is absorbed by roots and transported upward through the xylem to apoplastic space of leaf, after which it deposited into leaf cell. In Arabidopsis (Arabidopsis thaliana), tonoplast-localized Ca2+/H+ transporters CATION EXCHANGER1 (CAX1) CAX3 sequester from cytosol vacuole, but not known what transporter mediates initial influx apoplast cytosol. Here, we report that CYCLIC NUCLEOTIDE-GATED CHANNEL2 (CNGC2) encodes a protein with channel activity expressed in areas surrounding free...
Aberrant activation of beta-catenin/TCF4 and STAT3 signaling in glioblastoma multiforme (GBM) has been reported. However, the molecular mechanisms related to this process are still poorly understood.Genome-wide screening binding characteristics transcription factors TCF4 GBM cells was performed by chromatin immunoprecipitation sequencing (ChIP-seq) assay. Hierarchical clustering used analyze association coregulated genes with The Cancer Genome Atlas (TCGA) subtypes (classical, mesenchymal,...
Inducing high levels of antigen-specific CD8α
Cold stress poses a significant threat to viticulture, particularly under the increasing pressures of climate change. In this study, we identified VaMIEL1, RING-type E3 ubiquitin ligase from Vitis amurensis, as negative regulator cold tolerance. Under normal temperature conditions, VaMIEL1 facilitates ubiquitination and subsequent proteasomal degradation cold-responsive transcription factor VaMYB4a, thereby attenuating its regulatory role in CBF-COR signaling cascade. However, stress,...
Archaeal viruses with a spindle-shaped virion are abundant and widespread in extremely diverse environments. However, efforts to obtain the high-resolution structure of virus have been unsuccessful. Here, we present SSV19, infecting hyperthermophilic archaeon Sulfolobus sp. E11-6. Our near-atomic reveals an unusual sevenfold symmetrical tail consisting tailspike, nozzle, adaptor proteins. The capsid shell is formed by seven left-handed helical strands, constructed hydrophobic major protein,...
Melatonin (MEL) is an antioxidant molecule that enhances plant tolerance to environmental stress. However, the mechanisms by which MEL regulates cold signaling pathways in grapes under stress remain elusive. Here, we investigated physiological and transcriptomic changes grape seedlings treated with exogenous determine their protective role Results showed 150 μM effectively attenuated cold-induced cell damage reducing reactive oxygen species (ROS) preserving chloroplast structure function....
Fuselloviruses are among the most widespread and best-characterized archaeal viruses. They exhibit remarkable diversity, as list of members this family is rapidly growing. However, it has yet to be shown how a fuselloviral genome may undergo variation at levels both single nucleotides sequence stretches. Here, we report isolation characterization four novel spindle-shaped viruses, named Sulfolobus viruses 19 22 (SSV19-22), from hot spring in Philippines. SSV19 member genus Alphafusellovirus,...
Fusarium solani is the most significant pathogen that causes root rot in wolfberry, which has led to serious economic losses terms of production. As an important enzyme organisms, NADPH oxidase produces ROS. However, mechanism ROS mediated by growth F. not been studied. In this study, colonies were treated with 40 µmol/L DPI and 0.0012% H2O2. The rate colonies, number spores, key gene expression levels, activity enzymes content products metabolic pathways determined. results showed decreased...
Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading cytosolic nucleic acids, we...
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<div>Abstract<p>Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading...
<div>Abstract<p>Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading...
A large number of fuselloviruses have been found in acidic hot springs around the globe. They share a set highly conserved genes (core genes) and possess varying less-conserved (non-core genes). However, functions most these are unknown. Recent studies show that as many half tolerate mutation. In this study, we conducted genetic analysis on Saccharolobus spindle-shaped virus 22 (SSV22), an alphafusellovirus with fewer open reading frames (ORFs) than isolated fuselloviruses. Both deletion...