A5080479396- CRISPR and Genetic Engineering
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Semiconductor materials and devices
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Advanced Breast Cancer Therapies
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cold Atom Physics and Bose-Einstein Condensates
- Advanced Nanomaterials in Catalysis
- Animal Genetics and Reproduction
- Retinal Diseases and Treatments
- Chemokine receptors and signaling
- Congenital heart defects research
- Atomic and Subatomic Physics Research
- Ferroelectric and Negative Capacitance Devices
- Advanced Photocatalysis Techniques
- Prostate Cancer Treatment and Research
- Semiconductor materials and interfaces
- Cardiovascular Conditions and Treatments
- TiO2 Photocatalysis and Solar Cells
- Nanowire Synthesis and Applications
- Connexins and lens biology
National Yang Ming Chiao Tung University
2016-2025
National Tsing Hua University
2025
Academia Sinica
2022-2025
National Eye Institute
2025
National Institutes of Health
2025
National Central University
2021-2024
Institute of Biomedical Sciences, Academia Sinica
2024
North Central University
2023
Ministry of Health and Welfare
2023
Taipei Veterans General Hospital
2021-2022
Alternate forms of the PolII transcription initiation machinery have been proposed to play a role in selective activation cell-type-specific gene expression programs during cellular differentiation. The cannonball (can) Drosophila encodes homolog TBP-associated factor (dTAF5) protein expressed only spermatocytes, where it is required for normal genes spermatid We show that primary spermatocytes also express four additional tissue-specific TAFs: nht (homolog dTAF4), mia dTAF6), sa dTAF8) and...
Alternate forms of the general transcription machinery have been described in several tissues or cell types. However, role tissue-specific TBP-associated factors (TAF II s) and other components regulating differential gene expression during development was not clear. Here we show that cannonball Drosophila encodes a type-specific homolog more ubiquitously expressed component factor TFIID. is required vivo for high level set stage- target genes male gametogenesis. Regulation by absolutely...
The Forming phenomenon is observed via in situ transmission electron microscopy the Ag/Ta2O5/Pt system. device switched to a low-resistance state as dual filament connected electrodes. results of energy dispersive spectrometer and loss spectroscopy analyses demonstrate that composed by stack oxygen vacancies Ag metal. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized for online delivery, but not...
ABSTRACT Wild-type function of four Drosophila genes, spermatocyte arrest, cannonball, always early and meiosis I is required both for cell-cycle progression through the G2/M transition in males onset spermatid differentiation. In mutant any one these meiotic arrest mature primary spermatocytes with partially condensed chromosomes accumulate post-meiotic cells are lacking. The occurs prior to degradation cyclin A protein. block spermatogenesis mutants not simply a secondary consequence as...
Abstract Background The progression of nasopharyngeal carcinoma (NPC) is profoundly affected by Epstein-Barr virus (EBV) infection. However, the role EBV in intercommunication between NPC and surrounding stromal cells has yet to be explored. Methods biopsies were obtained for immunohistochemical (IHC) analyses. Clinical correlations expression active YAP1/FAPα fibrotic response density cytotoxic CD8a + T lymphocytes determined. Survival times based on IHC scores compared groups using...
Abstract Our study presents a 319-gene panel targeting inherited retinal dystrophy (IRD) genes. Through multi-center retrospective cohort study, we validated the assay’s effectiveness and clinical utility characterized mutation spectrum of Taiwanese IRD patients. Between January 2018 May 2022, 493 patients in 425 unrelated families, all initially suspected having without prior genetic diagnoses, underwent detailed ophthalmic physical examinations (with extra-ocular features recorded) testing...
Three new heteroleptic Ru complexes, CYC-B22, CYC-B23C, and CYC-B23T, were prepared as sensitizers for coadsorbent-free, panchromatic, efficient dye-sensitized solar cells. They are simultaneously functionalized with highly conjugated anchoring ancillary ligands to explore the electronic steric effects on their photovoltaic characteristics. The coadsorbent-free device based CYC-B22 achieved best power conversion efficiency (PCE) of 8.63% a panchromatic response extending 850 nm. two...
GLP-1 (glucagon-like peptide-1) has been reported to play a vital role in neuroprotection. Experimental autoimmune encephalomyelitis (EAE) is well-established animal model widely used study human multiple sclerosis, chronic demyelination disease the central nervous system (CNS). Recently, important studies have designated that signaling axis of and its receptor controls clinical manifestations pathogenesis EAE. However, it elusive whether regulates phenotype autoreactive T cells CNS. We...
Robot-assisted rehabilitation has gained popularity in the last two decades. The focus shifted from end-effector devices to wearable exoskeletons, emphasizing transition bulky machines portable devices. However, technology gap still exists on how design exoskeletons with high adaptability. This includes ensuring a sufficient degree of freedom and addressing potential offsets between different users. paper introduces cable-driven wrist exoskeleton having degrees (DoFs) designed finely adjust...
A design for frequency-reconfigurable antennas with conical-beam radiation is described. The based on the TM <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$_{02}$</tex></formula> mode of a coplanar annular-ring microstrip antenna, and several shorting strips are symmetrically placed along circumference radiating patch to vary its resonant frequency. effects number frequency characteristic...
The adipocyte-secreting adipokine, resistin, may play a critical role in the modulation of inflammatory diseases. Migration and infiltration mononuclear cells into sites are events during development osteoarthritis (OA). Monocyte chemoattractant protein-1 (MCP-1), also known as chemokine ligand 2 (CCL2), plays regulation monocyte migration infiltration. In this study, we show how resistin promotes MCP-1 expression OA synovial fibroblasts migration.We used qPCR to detect miRNA expression....
Transition metal silicide nanowires (NWs) have attracted increasing attention as they possess advantages of both silicon NWs and transition metals. Over the past years, there been reported with efforts on one in a single NW. However, research multicomponent silicides NW is still rare, leading to limited functionalities. In this work, we successfully fabricated β-Pt2Si/Si/θ-Ni2Si, β-Pt2Si/θ-Ni2Si, Pt, Ni, Si ternary phase axial heterostructures through solid state reactions at 650 °C. Using...
We report here the efficacy of surface-enhanced Raman spectroscopy (SERS) measurements as a probe for molecular orientation. 4-Aminobenzoic acid (PABA) on surface consisting silver (Ag) nanoparticles (NPs) is investigated. find that orientation PABA molecule SERS substrate estimated based relative change in magnitude C–H stretching bands substrate, and it found assumes horizontal Ag-NP surface. The strong molecule–metal interaction determined by an abnormal enhanced band appearing at 980...