- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Anorectal Disease Treatments and Outcomes
- Organ Donation and Transplantation
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Surgical Treatments
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Intensive Care Unit Cognitive Disorders
- Sarcoma Diagnosis and Treatment
- Reproductive Health and Technologies
- Cancer and Skin Lesions
- Molecular Biology Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Veterinary Oncology Research
- Urinary Bladder and Prostate Research
- Hernia repair and management
- Cancer Genomics and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
Poznan University of Medical Sciences
2010-2023
Heliodor Swiecicki Clinical Hospital
2016
Centrum Onkologii
2015
Cancer continues to be the leading cause of mortality in high-income countries, necessitating development more precise and effective treatment modalities. Immunotherapy, specifically adoptive cell transfer T receptor (TCR)-engineered cells (TCR-T therapy), has shown promise engaging immune system for cancer treatment. One biggest challenges TCR-T therapies is proper prediction pairing between TCRs peptide-human leukocyte antigen (pHLAs). Modern computational immunology, using artificial...
Peritoneal dialysis (PD) is a valuable 'home treatment' option, even more so during the ongoing Coronavirus pandemic. However, long-term use of PD limited by unfavourable tissue remodelling in peritoneal membrane, which associated with inflammation-induced angiogenesis. This appears to be driven primarily through vascular endothelial growth factor (VEGF), while involvement other angiogenic signaling pathways still poorly understood. Here, we have identified crucial contribution mesothelial...
Liposarcomas are the most common of all sarcomas. A well-differentiated liposarcoma can transform into a dedifferentiated with myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification
Objectives: Anatomical and functional results of a modified sacral perineocolporectopexy for extreme forms complex pelvic organs prolapse. Material methods:Between 2005 2010, 10 women aged 47-75 years were treated by abdomino-perineal implantation polypropylene mesh subsequently followed-up.They suffering from enterocele (9 pts), genital prolapse (8 descending perineum (5 rectal (4 rectocele (3 pts).Five incontinent (mean Wexner: 9) six had incomplete evacuation.Defecography revealed III°(5...
Treatment of unresectable liver metastases (LM) from uveal melanoma (UM) remains a major clinical challenge. Systemic chemotherapy and chemoimmunotherapy regimens extrapolated cutaneous are considered to be ineffective in therapy melanoma. Studies suggest that the progression hepatic rather than primary tumor or other organs determines survival.We report case transarterial chemoembolization 57-year-old man diagnosed with irinotecan eluting beads. Therapy resulted long free survival overall...
THE AIM OF STUDY was to present and compare own results of abdominal rectopexy performed with absorbable nonabsorbable materials used in surgical repair rectal prolapse.In the years 1991-2009, 50 patients were operated on for prolapse. The first 8 (group I) using absorbale polyglycolic acid mesh. next 42 non-absorbable polypropylene mesh II). 12 chronic, incurable constipation had sigmoidectomy at same operation. Rectopexy fixed pelvic fascia periosteum mesorectum, leaving anterior one third...
Purpose: Organ transplantation is a treatment for patients with end-stage organ failure limited by the number of organs. The aims this article are: to compare relevance indicated systems donated organs, analyze status donation, identify current issues and possible measures in order increase donations from deceased donors Poland. Design/methodology/approach: paper refers theories behavioral economics: quo bias, human tendency procrastinate, aversion changes. It also analyzes statistical data...
In many countries, including Poland, the main problem with transplantation is insufficiency of organ donors in relation to demand for organs. Hence, common aim globally increase pool donors. The prolonged survival patients after transplantation, respect time on dialysis, makes search much more intense. After recourse expanded criteria (ECD), next step was obtaining kidneys from irreversible cardiac death (DCD). Therefore, based Dutch, British, and Spanish experience, it can be hypothesized...
This report describes results of posterior vaginal wall prolapse and rectocele treatment performing tension free reconstruction method with polypropylene mesh implantation.In years 2001 to 20015, 71 female patients in age 42-82 were surgically treated. Besides difficult emptying they complained feeling heaviness the pelvis (38%) dyspareunia (16.9%). Defecography magnetic resonance proved presence 84.5%, enterocele 38%, descending perineum 28.2%, genital organ 23.9%, rectal 22.5% cases. 37...
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<sec> <title>BACKGROUND</title> Cancer continues to be the leading cause of mortality in high-income countries, necessitating development more precise and effective treatment modalities. Immunotherapy, specifically adoptive cell transfer T receptor (TCR)-engineered cells (TCR-T therapy), has shown promise engaging immune system for cancer treatment. One biggest challenges TCR-T therapies is proper prediction pairing between TCRs peptide-human leukocyte antigen (pHLAs). Modern computational...
We’ve built this digital research platform to provide academics everywhere with fast, stable and secure access our library of over 110,000 scholarly books 800,000 journal articles. tested the in close cooperation leading academic institutions. If you have any questions or notice something doesn’t quite work as it should, please visit <a href="/publishing/faq?lang=en" class="text-primary">Help/FAQ</a> page let us know.
Spontaneous hepatic rupture constitutes very rare complication of pregnancy and is associated with an increased risk mortality. The patient presented at 30 weeks gestation HELLP syndrome developed life threatening rupture. She underwent emergent cesarean delivery followed by exploration her abdomen hepatobiliary surgeons. An expanding hematoma the right left lobe liver was successfully treated radiofrequency ablation electrode. discharged home in good condition 13 days after surgery. Quick...