A5100719502- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Complex Systems and Time Series Analysis
- Circular RNAs in diseases
- Financial Risk and Volatility Modeling
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- Complex Network Analysis Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Polydiacetylene-based materials and applications
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- RNA regulation and disease
- Pluripotent Stem Cells Research
- Metamaterials and Metasurfaces Applications
- Autophagy in Disease and Therapy
- Nonlinear Optical Materials Studies
- Chaos control and synchronization
- Opinion Dynamics and Social Influence
Wenzhou Medical University
2022
Fuling Center Hospital of Chongqing
2022
Lanzhou University
2020
Lanzhou University Second Hospital
2020
China XD Group (China)
2019
Air Force Medical University
2008-2019
First Hospital of Qinhuangdao
2019
Tang Du Hospital
2019
East China University of Science and Technology
2016-2017
Abstract Expression profile of microRNA (miRNA) in mouse oocytes and preimplantation embryos has been revealed by a novel high throughput microarray assay. A total 97 (43 “new” 54 known) including mouse, human, predicted miRNAs have discovered the which can be classified into developmental stage‐dependent groups non–stage‐dependent group according to statistical analysis expression patterns. Potential gene targets each are estimated TargetsScan system significantly changed signaling pathways...
Non‑small cell lung cancer (NSCLC) is the most common type of accounting for ~80% cases. According to novel research, numerous microRNAs (miRs) have been suggested function as important regulators cancer. In addition, expression miR‑140‑5p decreased in patients with NSCLC. Therefore, it further elucidate role Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used order investigate NSCLC tissues and matched normal determine levels following transfection mimics into...
microRNA-290 (miR-290) clusters are highly expressed in mouse preimplantation embryos, but their specific role and regulatory mechanisms the development of embryos remain unclear. Here, we found that miR-291a-5p miR-291b-5p, as mature microRNA molecules miR-290 clusters, were dynamically embryos. The expression miR-291b-5p increased during 2-4-cell stages was accompanied by decreasing autophagy-related genes Atg5 Becn1 mRNA. Immunofluorescence studies showed formation autophagosomes...
Parthenogenetic embryonic stem cells have pluripotent differentiation potentials, akin to fertilized embryo-derived cells. The aim of this study was compare the neuronal potential parthenogenetic and Before differentiation, karyotype analysis performed, with normal karyotypes detected in both Sex chromosomes were identified as XX. Immunocytochemistry quantitative real-time PCR high expression gene, Oct4, at mRNA protein levels, indicating two cell subtypes. Embryonic induced retinoic acid...
We have compared the micro-RNAs expressed in mature oocytes, 2-cell, 8-cell and blastocyst stage embryos both qualitatively quantitatively using miRNA micro-arrays with a total of 509 human, rat, mouse, predicted probes. The discovered miRNAs were classified into 5 groups according to expression pattern including: oocyte, 2-cell embryo, specific generally group. Potential gene targets each group estimated by TargetsScan system. Gene from different that significantly changed represented...
Abstract Background and aim: Ischemic stroke is one of the main causes death worldwide permanent global disability. On basis existing literature data, we carried out studies in an effort to explore how miR-140-5p affects ischemic whether mechanism relates toll-like receptor-4 (TLR4) nuclear factor-kappa B (NF-κB). Methods: Middle cerebral artery occlusion (MCAO) was employed establish a mouse model vivo , while primary neurons were exposed oxygen-glucose deprivation (OGD) set up vitro ....