A5056863575- Barrier Structure and Function Studies
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Ferroptosis and cancer prognosis
- Hedgehog Signaling Pathway Studies
- Nanoparticle-Based Drug Delivery
- Advanced Glycation End Products research
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Caveolin-1 and cellular processes
- Neuropeptides and Animal Physiology
- Cancer, Lipids, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Asthma and respiratory diseases
- Brain Metastases and Treatment
- HIV Research and Treatment
- Glioma Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Ginger and Zingiberaceae research
- HIV-related health complications and treatments
- Phosphodiesterase function and regulation
Nagasaki University
2012-2024
Fukuoka University
2021-2023
University of Kentucky
2012
(1) The blood-brain barrier (BBB) characteristics of cerebral endothelial cells are induced by organ-specific local signals. Brain lose their phenotype in cultures without cross-talk with neighboring cells. (2) In contrast to astrocytes, pericytes, another cell brain capillaries, rarely used BBB co-culture systems. (3) Seven different types models, mono-culture, double and triple co-cultures, were constructed from primary rat cells, astrocytes pericytes on culture inserts. integrity the...
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) affects cross-talk between individual cell types neurovascular unit, which then contributes to disruption blood-brain barrier (BBB) and development neurological dysfunctions. Although toxicity HIV-1 on neurons, astrocytes brain endothelial cells has been widely studied, there are no reports addressing influence pericytes. Therefore, purpose this study was evaluate whether or not pericytes can be...
Abstract Parkinson’s disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors degradation have been used for PD therapy, death progresses during treatment. DJ‐1, causative gene product familial form PD, PARK7, plays roles in transcriptional regulation anti‐oxidative stress, loss its function thought to result the onset PD. Superfluous oxidation cysteine at amino acid 106 (C106) DJ‐1 renders inactive, such oxidized has observed patients with sporadic In...
Cerebral infarction accounts for 85% of all stroke cases. Even in an era rapid and effective recanalization using intravascular approach, the majority patients have poor functional outcomes. Thus, there is urgent need development therapeutic agents to treat acute ischemic stroke. We evaluated effect fasudil, a Rho kinase inhibitor, on blood brain barrier (BBB) functions under normoxia or oxygen-glucose deprivation (OGD) conditions primary cell-based vitro BBB model.BBB models from rat...