A5085308903- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Reconstructive Surgery and Microvascular Techniques
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- Global Cancer Incidence and Screening
- Cancer and Skin Lesions
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- AI in cancer detection
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
Agostino Gemelli University Polyclinic
2019-2025
Università Cattolica del Sacro Cuore
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Background: Implant-based breast reconstruction (IBBR) following conservative mastectomy is the most common approach for women undergoing cancer surgery. The aim of this study was to compare oncological outcomes combined with prepectoral IBBR subpectoral technique. Methods: clinical and demographic data consecutive patients who underwent either or between January 2018 December 2023 were retrospectively analyzed. primary outcome impact on local recurrence-free survival (LRFS). Secondary...
Mesenchymal tumors of the breast represent a rare and diverse group neoplasms, accounting for 0.5% all tumors. These originate from mesenchymal tissues encompass variety histological subtypes. Malignant are particularly aggressive, characterized by high propensity local recurrence an overall poor prognosis. The rarity these cases has hindered development robust clinical studies, resulting in lack standardized diagnostic treatment guidelines considerable variability management. This review...
Background: Breast cancer in women aged 80 years and older accounts for about 12% of cases, but its management is challenging due to the population’s heterogeneity lack relevant evidence-based guidelines. Treatment decisions must consider biological age, comorbidities, life expectancy, therapy-related toxicities, tumor biology. This study evaluates clinical outcomes elderly breast patients treated with a multidisciplinary approach, including oncologists, surgeons, geriatric specialists....
Background: Neoadjuvant chemotherapy (NACT) is effective in downstaging locally advanced breast cancer, improving surgical and oncological outcomes. However, luminal B cancer typically exhibits a poorer response to NACT, with only 10-15% of patients achieving pathologic complete (pCR). This study investigates whether BRCA pathogenic variants (BRCA PVs) influence pCR rates patients, aiming identify potential predictors for personalized treatment strategies. Materials Methods: retrospective...
Oncoplastic surgery (OPS) has demonstrated its superiority above traditional breast conserving surgery, but is still struggling to consolidate role in cancer therapeutic protocols mainly because of contrasting scientific evidences and reduced follow-up results available. The objective our contribution analyze obtained with 381 patients consecutively treated Multidisciplinary Breast Center by means level II OPS between January 1998 2018 for unilateral, primary cancer. Surgical endpoints were...
Sentinel lymph node biopsy (SLNB) following neoadjuvant treatment (NACT) has been questioned by many studies that reported heterogeneous identification (IR) and false negative rates (FNR). As a result, some patients receive axillary dissection (ALND) regardless of response to NACT, leading potential overtreatment. To better assess reliability clinical significance SLNB status on ycN0 patients, we retrospectively analyzed oncological outcomes 399 treated between January 2016 December 2019...
Background: Breast cancer in young women aged < 40 years is rare and often aggressive with less favorable survival rates. The lack of systematic screening, later stage at diagnosis, a more disease biology may all contribute to their poor prognosis. Data on the best management remain conflicting, especially those regarding surgical management, either breast-conserving or mastectomy. To our knowledge, there are limited studies surrounding treatment early breast cancer, this analysis...
Radiotherapy (RT) shows potential for improving local control in cases of oligoprogressive metastatic breast cancer (mBC). This retrospective analysis aims to evaluate the advantages RT such a clinical scenario.
Since the beginning of COVID 19 outbreak, a number guidelines and recommendations have been released on how to best readapt clinical activities, including breast cancer care. The American College Surgeons' Pandemic Breast Cancer Consortium (which comprises National Accreditation Program for Centers, Commission Cancer, Society Surgeons, Comprehensive Network) recommended reprioritize treatment basing three phases acuity local COVID-19 situation hospital capacities ("semi-urgent," "urgent,"...
B3 breast lesions, classified as lesions of uncertain malignant potential, present a significant di-agnostic and therapeutic challenge due to their heterogeneous nature variable risk pro-gression malignancy. These which include atypical ductal hyperplasia (ADH), papil-lary (PL), flat epithelial atypia (FEA), radial scar (RS), lobular neoplasia (LN), phyl-lodes tumors (PT), occupy &quot;grey zone&quot; between benign pathologies, making management complex often controversial. This...
Background: Breast cancer in women aged 80 years and over accounts for about 12% of cases, but its management remains difficult due to the heterogeneity this population absence relevant evidence-based guidelines. Treatment decisions must integrate considerations biological age, comorbidities, life expectancy, therapy-related toxicities alongside tumor biology stage. This study aims evaluate clinical outcomes elderly breast patients treated at our Institution through a multidisciplinary...
Background/Objectives: B3 breast lesions, characterized by uncertain malignant potential, pose a significant challenge for clinicians. With the increasing use of preoperative biopsies, there is need careful management strategies, including watchful waiting, vacuum-assisted excision (VAE), and surgery. This study aims to assess concordance between biopsy findings postoperative histology, with focus on evaluating positive predictive value (PPV) malignancy in lesions. Methods: Over seven-year...
Background: Oncoplastic surgery (OPS) reliability in the post-neoadjuvant chemotherapy (NACT) setting is still debated due to weak scientific evidences such scenarios. Methods: Our analysis aims report results obtained a retrospective series of 111 patients consecutively treated with level II OPS after NACT at Multidisciplinary Breast Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS between 1998 and 2018. The surgical endpoints were mean specimen volume, rates positive...