A5087497958- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electronic Packaging and Soldering Technologies
- 3D IC and TSV technologies
- Electrohydrodynamics and Fluid Dynamics
- 3D Printing in Biomedical Research
- Energy Harvesting in Wireless Networks
- Innovative Energy Harvesting Technologies
- Electrical and Bioimpedance Tomography
- Heat Transfer and Optimization
- Microwave Engineering and Waveguides
- Biosensors and Analytical Detection
- Advanced Sensor and Energy Harvesting Materials
- Nanomaterials and Printing Technologies
- Fluid Dynamics and Thin Films
- Wireless Power Transfer Systems
- Nanopore and Nanochannel Transport Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanofabrication and Lithography Techniques
- Optical Imaging and Spectroscopy Techniques
- Fluid Dynamics and Turbulent Flows
- Advanced Surface Polishing Techniques
- Extracellular vesicles in disease
University of Southern California
2017-2025
Tamil Nadu Agricultural University
2025
Dana-Farber Cancer Institute
2024
State Key Laboratory of Oncology in South China
2023
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Jacobs (United States)
2022
Alfred Mann Foundation
2019
Los Angeles City College
2018
Southern California University for Professional Studies
2018
For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack rewritability, associated benefits multi-path routing re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed complexity reaction test matrices. We present contactless droplet...
Acoustofluidic centrifugation enables the spinning of a fluidic droplet and nanoparticle enrichment separation.
To determine the expression of components in Toll-like receptors (TLRs)/Nod-like (NLRs)/inflammasome/caspase-1/interleukin (IL-1)-β pathway, we examined profiles those genes by analyzing data from sequence tag cDNA cloning and sequencing. We made several important findings: firstly, among 11 tissues examined, vascular heart express fewer types TLRs NLRs than immune defense including blood, lymph nodes, thymus trachea; secondly, brain, nodes do not proinflammatory cytokines IL-1β IL-18...
We present a theoretical analysis and experimental demonstration of particle trapping manipulation around optothermally generated bubbles. show that located within 500 μm surface bubble can be attracted towards by drag force resulting from convective flow. Once the comes in contact with bubble's surface, balance between tension forces pressure traps on allowing to move without detaching. The proposed mechanism is confirmed computational fluid dynamics simulations, calculations, experiments....
Acoustic tweezers enable contactless, dynamic, precise, and multifunctional manipulation of bioparticles in Petri dishes.
After half a billion years of evolution, arthropods have developed sophisticated compound eyes with extraordinary visual capabilities that inspired the development artificial eyes. However, limited 2D nature most traditional fabrication techniques makes it challenging to directly replicate these natural systems. Here, we present biomimetic apposition eye fabricated using microfluidic-assisted 3D-printing technique. Each microlens is connected bottom planar surface via intracorporal,...
Abstract Modern biomedical research and preclinical pharmaceutical development rely heavily on the phenotyping of small vertebrate models for various diseases prior to human testing. In this article, we demonstrate an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging digital reconstruction zebrafish larvae quantitative phenotypic analysis. The acoustic-induced polarized vortex streaming achieves contactless rapid (~1 s/rotation)...
Separation of particles and cells is an important function in many biological biomedical protocols.
Advances in lab-on-a-chip technologies are driven by the pursuit of programmable microscale bioreactors or fluidic processors that mimic electronic functionality, scalability, and convenience. However, few mechanisms allow for basic logic operations on rewritable paths due to cross-contamination, which leads random interference between "fluidic bits" droplets. Here, we introduce a mechanism allows contact-free gating individual droplets based scalable features acoustic streaming vortices...
Decomposition and control of acoustic streaming enable contact-free manipulation bioanalytes digitalized liquid handling.
High-precision isolation of small extracellular vesicles (sEVs) from biofluids is essential toward developing next-generation liquid biopsies and regenerative therapies. However, current methods sEV separation require specialized equipment time-consuming protocols have difficulties producing highly pure subpopulations sEVs. Here, we present Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER), which allows single-step, rapid (<10 min), high-purity (>96% exosomes, >80%...
In this paper, we present an algorithm for hand gesture tracking and recognition based on the integration of a custom-built microelectromechanical systems (MEMS)-based inertial sensor (or measurement unit) low resolution imaging (i.e., vision) sensor. We discuss 2-D results here, but can be extended to 3-D motion in future. Essentially, paper shows that data sampled at 100 Hz vision 5 frames/s could fused by Kalman filter, used accurate human tracking. Since is better rapid movements, while...
Extracellular vesicle (EV) surface proteins, expressed by primary tumours, are important biomarkers for early cancer diagnosis. However, the detection of these EV proteins is complicated their low abundance and interference from non-EV components in clinical samples. Herein, we present a MEmbrane-Specific Separation two-step Cascade AmpLificatioN (MESS2CAN) strategy direct within 4 h. MESS2CAN utilises novel lipid probes (long chains linked PEG2K with biotin at one end, DSPE other end)...
Degradation of extracellular matrix proteins by proteases such as the cysteine protease cathepsin B is critical to malignant progression. We have established that procathepsin presents on surface tumor cells through its interaction with annexin II tetramer [Mai et al., J. Biol. Chem. 275 (2000), 12806 12812]. Cathepsin activity can also be detected cell and in their culture medium. Interestingly, interacts proteins, collagen I, fibrin tenascinC. Both tenascinC are expressed at high levels...
Highly surface-roughened Ag nanoplate arrays are fabricated using a simple electrodeposition and in situ electrocorrosion method with inorganic borate ions as capping agent. The process is induced by change the local pH value during electrochemical growth, which used to intentionally carve electrodeposited structures. three dimensionally arranged nanoplates integrated substantial surface-enhanced Raman scattering (SERS) hot spots free of organic contaminations widely shaping agents previous...
The culturing of cancer cells on micropatterned substrates can provide insight into the factors extracellular environment that enable control cell growth. We report here a novel non-UV-based technique to quickly micropattern poly-(ethylene) glycol diacrylate (PEGDA)-based hydrogel top modified glass substrates, which were then used growth patterns breast cells. Previously, fabrication required relatively complicated steps, made it impractical for researchers rapidly and systematically...
Abstract We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The individually trapped bubbles, known sizes, microchannels was studied at both fixed frequency over range frequencies. Resonant frequencies were analytically identified found to be agreement the experimental observations. acoustic streaming by as cause this enhanced extraction. Experiments extracting...