A5010614822- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Micro and Nano Robotics
- Advanced biosensing and bioanalysis techniques
- Photonic and Optical Devices
- Carbon Nanotubes in Composites
- Conducting polymers and applications
- Molecular Communication and Nanonetworks
- Nanopore and Nanochannel Transport Studies
- Organic Electronics and Photovoltaics
- Advanced Fiber Optic Sensors
- Orbital Angular Momentum in Optics
- Aerosol Filtration and Electrostatic Precipitation
- Electrostatics and Colloid Interactions
- Acoustic Wave Resonator Technologies
- Graphene research and applications
- Advanced Fiber Laser Technologies
- Carbon and Quantum Dots Applications
- Advancements in Battery Materials
- Simulation Techniques and Applications
- ECG Monitoring and Analysis
- Material Properties and Applications
- Collagen: Extraction and Characterization
- solar cell performance optimization
Pennsylvania State University
2015-2021
Xi'an Aeronautical University
2021
Park University
2015-2017
Fudan University
2011-2017
Texas Tech University
2010-2013
City University of Hong Kong
1997-1998
Significance We present 3D acoustic tweezers, which can trap and manipulate single cells particles along three mutually orthogonal axes of motion by recourse to surface waves. use tweezers pick up cells, or entire cell assemblies, deliver them desired locations create 2D patterns, print the into complex shapes. This technology is thus shown offer better performance over prior manipulation techniques in terms both accurate precise a noninvasive, label-free, contactless manner. method offers...
Trapped bubbles make for fast and controllable microswimmers that can push or pull living cells in crowded microenvironments.
For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack rewritability, associated benefits multi-path routing re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed complexity reaction test matrices. We present contactless droplet...
A 3D acoustic tweezers platform is developed to fabricate size-controllable multicellular spheroids in a rapid and high-throughput manner, utilizing the Gor'kov potential field microstreaming.
Rheotaxis is a common phenomenon in nature that refers to the directed movement of micro-organisms as result shear flow. The ability mimic natural rheotaxis using synthetic micro/nanomotors adds functionality enable their applications biomedicine and chemistry. Here, we present hybrid strategy can achieve both positive negative bimetallic micromotors by employing combination chemical fuel acoustic force. An acoustofluidic device developed for integration two propulsion mechanisms. Using...
We developed a standing surface acoustic wave (SSAW)-based cell sorting device. The throughput of our device has been significantly improved by using focused interdigital transducers (FIDTs) as SSAW generator.
The separation of nanoscale particles based on their differences in size is an essential technique to the nanoscience and nanotechnology community. Here, nanoparticles are successfully separated a continuous flow by using tilted‐angle standing surface acoustic waves. field deflects volume, fractionation optimized tuning cutoff parameters. nanoparticlesis demonstrated with ≈90% recovery rate. nanoparticle method versatile, non‐invasive, simple.
An acoustic separation device that can achieve high-throughput, high-efficiency, and non-invasive platelet enrichment from undiluted whole blood.
ConspectusEngines and motors are everywhere in the modern world, but it is a challenge to make them work if they very small. On micron length scale, inertial forces weak conventional motor designs involving, e.g., pistons, jets, or flywheels cease function. Biological by different principle, using catalysis convert chemical mechanical energy on nanometer scale. To do this, must apply force continuously against their viscous surroundings, because of small size, movement “jittery” random...
Microfluidic fluorescence-activated cell sorters (μFACS) have attracted considerable interest because of their ability to identify and separate cells in inexpensive biosafe ways. Here a high-performance μFACS is presented by integrating standing surface acoustic wave (SSAW)-based, 3D cell-focusing unit, an in-plane fluorescent detection SSAW-based cell-deflection unit on single chip. Without using sheath flow or precise rate control, the technique can focus into file at designated position....
Fullerene-functionalized graphene shows a hierarchical structure, and is promising for many potential applications. In this paper, new method presented to synthesize such novel nanostructure. Graphite flakes were intercalated graphite oxide, then functionalized with zero-dimensional fullerene nanocrystals. The resultant compounds characterized by FT-IR spectroscopy, UV–Vis atomic force microscopy, transmission electron microscopy. characterization results confirmed that crystals successfully...
In this paper, a 'green' and safe hydrothermal method has been used to reduce graphene oxide produce hemin modified nanosheet (HGN) based electrochemical biosensors for the determination of l-tyrosine levels. The as-fabricated HGN were characterized by UV–visible absorption spectra, fluorescence Fourier transform infrared spectroscopy (FTIR) spectra thermogravimetric analysis (TGA). experimental results indicated that was successfully immobilized on reduced (rGO) through π–π interaction. TEM...
Selective isolation of cell subpopulations with defined biological characteristics is crucial for many studies and clinical applications. In this work, we present the development an acoustofluidic fluorescence activated sorting (FACS) device that simultaneously performs on-demand, high-throughput, high-resolution detection sorting, integrated onto a single chip. Our FACS uses "microfluidic drifting" technique to precisely focus cells/particles three dimensionally achieves flow single-file...
We numerically and experimentally investigate the acoustophoresis of microparticles in standing surface acoustic wave microfluidic devices.
Reusable acoustic tweezers used for disposable devices are demonstrated using locally transmitted standing surface waves.
We report the synthesis and properties of rod-shaped gold/iron oxide nanomotors that are powered by visible light in dilute hydrogen peroxide solutions. Electrochemical measurements confirmed light-driven operate a self-electrophoretic mechanism, modulated photovoltage photoconductivity oxide. Due to magnetism iron oxide, can be steered an external magnetic field without incorporating additional materials into nanomotors.
Ultrahigh sensitivity is achieved in a new active sensor structure: coupled optofluidic ring laser. The consists of one laser and tube. emission intensity the multimode whispering gallery resonance from strongly modulated. By using tube as sensing element, monitoring envelope shift modulated lasing spectrum, we 5930 nm/RIU, which two orders magnitude higher than conventional resonator sensor.
The first microfluidic-based on-chip sputum-liquefaction device is demonstrated <italic>via</italic> an acoustofluidic micromixer.
We report the fabrication of tadpole-shaped Si–Au micromotors using glancing angle deposition.
Acoustic manipulation of fluids and particles garners increasing interest for use in medicine biotechnology. One approach is based on actuation confined, acoustically ``leaky'' systems, but finding accurate physical models them has been stymied by a lack relevant empirical data. To advance the field, authors provide experimental benchmark results particle trajectories three dimensions, describe with minimal numerical model. They reveal that pseudo-standing wave drives acoustic streaming...
Density and mechanical properties (e.g., compressibility or bulk modulus) are important cellular biophysical markers. As such, developing a method to separate cells directly based on these can benefit various applications including biological research, diagnosis, prognosis, therapeutics. potential solution, surface acoustic wave (SAW)-based cell separation has demonstrated advantages in terms of biocompatibility compact device size. However, most SAW-reliant separations achieved using an...
Contact-free manipulation of small objects (e.g., cells, tissues, and droplets) using acoustic waves eliminates physical contact with structures undesired surface adsorption. Pioneering acoustic-based, contact-free techniques levitation) enable programmable but are limited by evaporation, bulky transducers, inefficient coupling in air. Herein, we report an acoustofluidic mechanism for the contactless on water. A hollow-square-shaped interdigital transducer (IDT) is fabricated lithium niobate...
A coupled optofluidic ring laser sensor is fabricated, and its ultrasensitive bulk refractive index surface mass sensing properties are demonstrated. The consists of a cylindrical thin-walled capillary resonator. Coupling the whispering gallery mode in two resonators generates largely magnified sensitivity due to Vernier effect. 2510 nm/RIU magnification factor 355 achieved experimentally aqueous solution, which corresponds noise equivalent detection limit 1.6×10(-5) RIU for RI detection....
For sputum analysis, the transfer of inflammatory cells from liquefied samples to a culture medium or buffer solution is critical step because it removes presence residual dithiothreitol (DTT), reagent that reduces cell viability and interferes with further analyses. In this work, we report an acoustofluidic platform for transferring using standing surface acoustic waves (SSAW). particular, exploit radiation force generated SSAW field actively containing DTT solution. The integrity are...
Abstract The emerging development of the hybrid plasmonic waveguide has recently received significant attention owing to its remarkable capability enabling subwavelength field confinement and great transmission distance. Here we report a guiding approach that integrates plasmon polariton with dielectric-loaded waveguiding. By introducing deep-subwavelength dielectric ridge between slab metallic substrate, nanoridge is formed. features lower propagation loss than conventional waveguiding...