A5085728469- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Sexual function and dysfunction studies
- Lung Cancer Treatments and Mutations
- Cutaneous Melanoma Detection and Management
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
Hospices Civils de Lyon
2024
Université Claude Bernard Lyon 1
2024
Centre Hospitalier Universitaire de Saint-Étienne
2024
Centre Hospitalier Universitaire Amiens-Picardie
2022
Hôpital Beaujon
2017-2021
Assistance Publique – Hôpitaux de Paris
2012-2021
Inserm
2012-2021
Sorbonne Université
2012-2021
Centre National de la Recherche Scientifique
2009-2021
Laboratoire d’Imagerie Biomédicale
2014-2021
The purpose of this study was to evaluate contrast-enhanced Doppler sonography with perfusion software as a predictor early tumor response imatinib (Glivec) in c-kit-positive gastrointestinal stromal tumors (GISTs).Thirty patients (59 tumors) metastases or recurrence from GIST were prospectively included single-center imaging trial. Contrast-enhanced performed an Aplio scanner the day before (day-1) starting oral treatment (400 mg) and at days 1, 7, 14, 60, 90, 6 months, 9 1 year. percentage...
Abstract Most patients with advanced ovarian cancer (AOC) ultimately relapse after platinum-based chemotherapy. Combining bevacizumab, olaparib, and durvalumab likely drives synergistic activity. This open-label phase 2 study (NCT04015739) aimed to assess activity safety of this triple combination in female relapsed high-grade AOC following prior therapy. Patients were treated olaparib (300 mg orally, twice daily), the bevacizumab biosimilar FKB238 (15 mg/kg intravenously,...
Abstract Purpose: To determine the safety, maximum tolerated dose, pharmacokinetics, and efficacy, to evaluate biomarkers, of multikinase inhibitor sorafenib plus IFN α-2a in advanced renal cell carcinoma (RCC) or melanoma. Experimental Design: Patients received 28-day cycles continuous, oral twice daily s.c. thrice weekly: 200 mg 6 million IU (MIU) weekly (cohort 1); 400 MIU 2); 9 3). Tumor response was assessed by Response Evaluation Criteria Solid Tumors dynamic contrast-enhanced...
To investigate the presence and impact of spontaneous telomerase-specific CD4 T-cell responses in cancer patients.A multistep approach was used to design novel pan-HLA-DR-restricted peptides from telomerase. clones isolated patients were characterize polarization response. The response against telomerase monitored 84 metastatic non-small cell lung (NSCLC) before first-line chemotherapy (CT) using IFN-γ ELISPOT assay. Then we analyzed pretherapeutic T immunity on clinical outcome according...
Background: Hemostatic complications, ranging from thromboembolism to bleeding, are a significant source of morbidity and mortality in cancer patients. The tumor coagulome represents the multiple genes proteins that locally contribute equilibrium between coagulation fibrinolysis. We aimed study Oral Squamous Cell Carcinoma (OSCC) examine its link microenvironment (TME). Methods: used data bulk DNA/RNA-seq (The Cancer Genome Atlas), single-cell RNA-seq OSCC cells culture. Results: Among all...
The objective of this work is to evaluate in a selection patients with erectile dysfunction the influence alcohol consumption and response abstinence without sildenafil association. Materials Methods. In population 150 consecutive we studied 50 aged between 22 77 years (mean 56±14 SD). These were divided into three different treatment groups screened for levels risk two questionnaires. All evaluated an International Index Erectile Dysfunction (IIEF) questionnaire before after one month...
The immune checkpoint molecule PD-L1 (CD274) is a crucial regulator of the tumor response. Its expression has been reported in therapeutic context Head and Neck Squamous Cell Carcinoma (HNSCC), but it remains unclear how therapeutically approved molecules regulate HNSCC cells. Three cell lines (BICR6, PE/CA-PJ34 PE/CA-PJ41) were used to analyze by immunoblotting, immunofluorescence QPCR. Freely-available single RNAseq data from also used. 5-Fluorouracil (5-FU) increased with high efficacy...
3069 Background: BAY 43–9006 (BAY) is a novel Raf kinase and VEGFR inhibitor currently under investigation in phase III trials for the treatment of metastatic renal cancer (MRCC). appears to have strong anti-angiogenic activity. The objective this study evaluate Doppler Ultrasonography with perfusion software (Vascular Recognition Imaging, Toshiba) contrast agent injection (Sonovue - Bracco) (DUSVRI) as predictor tumor response new progression-free survival (PFS). Methods: Tumor...
9539 Background: DCE-US combined with perfusion software VRI (Vascular Recognition Imaging) and contrast agent injection (Sonovue-Bracco) is a simple reproductible imaging technique that allows an early accurate evaluation of IM activity in GIST patients (Lassau et al, ASCO 2004). The objective this study was to correlate the results observed outcome c-Kit-positive pts treated detect secondary resistance IM. Methods: 36 advanced were prospectively included monocentric trial. performed before...
Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer even rarer, with only limited number such cases reported in literature date. We herein report case an 86-year-old female patient who had undergone mastectomy axillary lymphadenectomy for invasive ductal cell carcinoma 2 years prior, followed by adjuvant hormonal therapy letrozole. During hospitalization anemia associated inflammatory syndrome abdominal pain menorrhagia, ultrasound...
9048 Background: To evaluate Doppler-Ultrasonography with perfusion software and contrast agent injection (DUPSCA) as a predictor of tumor response to imatinib (Gleevec® ) in positive c-Kit GIST. Methods: Patients (pts) advanced GIST treated by (French BFR14 trial) were prospectively included monocentric imaging trial. DUPSCA was performed sonograph Aplio using (Toshiba) before administration (d0), on day1, 7, 14, 60, then every 3 months (m). The percentage uptake evaluated at each site two...