A5035158639- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Electrical and Bioimpedance Tomography
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound in Clinical Applications
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Cancer and biochemical research
- Microfluidic and Bio-sensing Technologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Research and Treatments
- Lanthanide and Transition Metal Complexes
- Elasticity and Material Modeling
- Nanoparticle-Based Drug Delivery
- Infrared Thermography in Medicine
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ultrasonics and Acoustic Wave Propagation
- Pancreatic and Hepatic Oncology Research
- Body Contouring and Surgery
- Electron Spin Resonance Studies
- Hematological disorders and diagnostics
EDAP TMS (France)
2024
Inserm
2014-2023
Laboratoire des applications Thérapeutiques des Ultrasons
2023
Université Claude Bernard Lyon 1
2023
Columbia University Irving Medical Center
2017-2020
Laboratoire d’Imagerie Biomédicale
2015-2019
Sorbonne Université
2011-2019
Centre National de la Recherche Scientifique
2012-2019
ESPCI Paris
2019
Physique pour la médecine Paris
2019
Pancreatic ductal adenocarcinoma (PDA) is a common, deadly cancer that challenging both to diagnose and manage. Its hallmark an expansive, desmoplastic stroma characterized by high mechanical stiffness. In this study, we sought leverage feature of PDA for two purposes: differential diagnosis monitoring response treatment.Harmonic motion imaging (HMI) functional ultrasound technique yields quantitative relative measurement stiffness suitable comparisons between individuals over time. We used...
Background and aims: Poor specificity predictive values of current cross-sectional radiological imaging methods in evaluation pancreatic adenocarcinoma (PDAC) limit the clinical capability to accurately stage tumor pre-operatively provide optimal surgical treatment improve patient outcomes. Methods: In this study, we applied Harmonic Motion Elastography (HME), a quantitative ultrasound-based method calculate Young's modulus (YM) PDAC mouse models (n = 30) human resection specimens (n=32). We...
Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep transcranial monitoring brain the dynamics in slow-flowing blood vessels remains challenging. To enhance fUS capabilities, we introduce biomolecular hemodynamic enhancers based on gas vesicles (GVs), genetically encodable contrast agents derived from buoyant photosynthetic microorganisms. We...
Harmonic motion imaging (HMI) is a radiationforce- based elasticity technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting displacement denoting underlying stiffness. The objective of this study was evaluate feasibility HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. system consisted transducer, which generated induce at 50 Hz, diagnostic detected axial on acquired...
The successful clinical application of High Intensity Focused Ultrasound (HIFU) ablation depends on reliable monitoring the lesion formation.Harmonic Motion Imaging guided (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU based stiffness change tissue instead echo intensity in conventional B-mode monitoring, rendering it potentially more sensitive to development.Our group has shown that predicting location radiation force-excited region feasible during...
Recently, ultrasonic imaging of soft tissue mechanics has been increasingly studied to image otherwise undetectable pathologies. However, many underlying mechanisms stiffening remain unknown, requiring small animal studies and adapted elasticity mapping techniques. Harmonic motion (HMI) assesses viscoelasticity by inducing localized oscillation from a periodic acoustic radiation force. The objective this study was evaluate the feasibility HMI for in vivo abdominal organs animals....
Perfusion parameter estimation from dynamic contrast-enhanced ultrasound (DCE-US) data relies on fitting parametric models of flow to curves describing linear echo power as a function time. The least squares criterion is generally used fit these data. This optimal in the sense maximum likelihood under assumption an additive white Gaussian noise. In current work, it demonstrated that this not held for DCEUS. A better-adapted based multiplicative model proposed. It tested simulated bolus...
Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a technique that can perform and monitor high-intensity focused ultrasound (HIFU) ablation. An oscillatory motion generated at the focus of 93-element 4.5 MHz center frequency HIFU transducer by applying 25 Hz amplitude-modulated signal using function generator. A 64-element 2.5 imaging with 68kPa peak pressure confocally placed to acquire radio-frequency (RF) channel data. In this protocol, real-time monitoring thermal ablation an...
Noninvasive quantitative assessment of coagulated tissue during high-intensity focused ultrasound (HIFU) ablation is one the essential steps for tumor treatment, especially in such cases as Pancreatic Ductal Adenocarcinoma (PDA) that has low probability diagnosis at early stages and high forming solid carcinomas resistant to chemotherapy treatment late stages.Harmonic motion elastography (HME) a technique localized estimation stiffness. This harmonic imaging (HMI)-based designed map Young's...
High-intensity Focused Ultrasound (HIFU) is a promising treatment modality for wide range of pathologies including prostate cancer. However, the lack reliable ultrasound-based monitoring technique limits its clinical use. currently provides real-time HIFU planning, but use usually limited to detecting backscatter increase resulting from chaotic bubble appearance. has been shown generate stiffening in various tissues, so elastography an interesting lead ablation monitoring. standard...
Harmonic motion imaging (HMI) is a radiation-force-based ultrasound elasticity technique, which designed for both tissue relative stiffness and reliable high-intensity focused treatment monitoring. The objective of this letter to develop demonstrate the feasibility 2-D (FUS) beam steering HMI using 93-element, FUS phased array. with steered was acquired in tissue-mimicking phantoms. displacement imaged within range ±1.7 mm laterally ±2 axially. Using beam, can be used image larger volume...
Harmonic motion imaging (HMI) is a radiation force-based elasticity technique that tracks tissue harmonic displacements induced by periodic ultrasonic force to assess stiffness. The objective of this study was evaluate the feasibility HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. system consisted transducer (FUS), which generated induce at 50 Hz, diagnostic transducer, detected axial displacement within targeted region using 1D...
Dynamic contrast-enhanced ultrasonography (DCE-US) can detect perfusion modifications during anti-angiogenic therapy preceding tumor size regression. In particular, parameters be useful to predict the early response of a patient therapy. However, assessment is sensitive injection variability. this work, we propose method for controlled ultrasound contrast agent and demonstrate improved evaluation enhancement obtained relative manual injections both in vitro vivo experiments. Perfusion area...
Assessing structural organization and dynamics of tumor blood supply is highest interest since numerous cancer treatments rely on antiangiogenic effects. Dynamic Contrast Enhanced Ultrasound (DCE-US) widely used in research to extract quantitative parameters reflecting perfusion. However, the underlying vascular structure not revealed local spatial fluctuations DCE parametric maps remain unexplained. The recently introduced Ultrafast Doppler Tomography (UFD-T) has been shown able reconstruct...
To estimate perfusion using Dynamic Contrast-Enhanced Ultrasound (DCE-US), some manufacturers provide software that analyses DICOM Raw Data formatted files. In those files, most of the information cannot be correctly interpreted except by manufacturer software. This approach when available is often recommended over use more accessible JPEG files which encapsulate ultrasound system images as compressed images. However, manufacturers' dedicated machine specific with limited functionalities...
Contrast ultrasound can detect perfusion modifications during anti-angiogenic therapy preceding tumor size regression. However, contrast imaging would benefit from better standardization of the technique. This work compared discrimination renal neuroblastoma (Wilm's tumor) in placebo and Sorafenib-treated mice using Sonovue microbubbles. Orthotopic tumors were induced 15 nude randomized into a control treated group. Conventional performed periodically prior to up 8 day after onset therapy....
The need to detect cancer at its early stages, as well as, deliver chemotherapy targeted site motivates many researchers build theranostic platforms which combine diagnostic and therapy. Among imaging modalities, ultrasonography Magnetic Resonance Imaging (MRI) are widely available, non invasive complement each other. Both techniques often require the use of contrast agents. We have developed nanocapsules perfluorooctyl bromide dual agent for both modalities. soft, amorphous polymer shell...
Recently, we have shown that Harmonic Motion Imaging (HMI) can be used to differentiate relative stiffness and monitor HIFU ablations in small lumpectomy human breast specimens. The objective of this study is apply HMI on post-surgical mastectomy specimen mimic the vivo environment characterize tumor at different depth for better localization identification before after treatment. 2D displacement maps could generated map induced peak-to-peak covering entire target area within two minutes...
The LabTAU is a household name in the history of biomedical ultrasound. Our philosophy to transfer our research from bench patient. As such, we are striving be at forefront emerging techniques while nurturing clinical and industrial partnerships. focuses on four main areas: high-energy ultrasound, low-energy bubbles cells particles, wave instrumentation. After briefly presenting geographical context laboratory, tour facility, showcasing experimental platforms by using examples active across...
This study investigates the feasibility of generating histotripsy lesions in biological tissues ex vivo with HIFU clinical device FocalOne® (EDAP-TMS). The Focal One® probe, composed a 192-element imaging array and 16-element therapy transducer operating at 3 MHz, was used an upgraded amplifier (ADECE, 500W, 200 kHz-6MHz ) Verasonics Vantage system for passive cavitation elastography monitoring. To ensure reproducibility, efficiency, safety, efforts were directed into electrical hardware...