A5102863746- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- LGBTQ Health, Identity, and Policy
- Syphilis Diagnosis and Treatment
- HIV/AIDS Impact and Responses
- HIV-related health complications and treatments
- Food Security and Health in Diverse Populations
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Zoonotic diseases and public health
- Adolescent and Pediatric Healthcare
- Antibiotics Pharmacokinetics and Efficacy
- Genital Health and Disease
- Sexuality, Behavior, and Technology
- Animal Disease Management and Epidemiology
- Smoking Behavior and Cessation
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Vaccine Coverage and Hesitancy
- Hepatitis C virus research
Fenway Health
2013-2025
Harvard University
2013-2025
Beth Israel Deaconess Medical Center
2014-2025
Harvard Global Health Institute
2024
Miriam Hospital
2005-2017
Brown University
1996-2017
John Brown University
2008-2017
San Francisco Foundation
2017
University of California, San Francisco
2017
University of North Carolina at Chapel Hill
2017
Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition.
Pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy. There little scientific consensus about how to measure PrEP program implementation progress. We draw on several years of experience in implementing programs and propose a continuum care that includes: (1) identifying individuals at highest risk for contracting HIV, (2) increasing awareness among those individuals, (3) enhancing awareness, (4) facilitating access, (5) linking care, (6) prescribing PrEP, (7) initiating...
Importance Syphilis rates have been increasing in the US for past decade. The incidence of Jarisch-Herxheimer reaction (JHR) after penicillin treatment early syphilis is reported to range from 8% 56%. Objectives To prospectively assess JHR signs and symptoms among adults with treated benzathine G document factors associated response outcomes. Design, Setting, Participants main study was designed as a phase 4 randomized clinical trial compare efficacy 1 vs 3 doses syphilis, measured serologic...
Objectives: To evaluate the clinical safety of daily tenofovir disoproxil fumarate (TDF) among HIV-negative men who have sex with men. Design: Randomized, double-blind, placebo-controlled trial. Participants were randomized 1:1:1:1 to immediate or delayed study drug (TDF, 300 mg orally per day, placebo). Methods: Four hundred healthy HIV-uninfected reporting anal another man within previous 12 months enrolled in Atlanta, Boston, and San Francisco. HIV serostatus, laboratory adverse events...
Oral preexposure prophylaxis (PrEP) trials report disparate efficacy attributed to variable adherence. HPTN 066 was conducted establish objective, quantitative benchmarks for discrete, regular levels of adherence using directly observed dosing tenofovir (TFV) disoproxil fumarate (TDF)/emtricitabine (FTC). Healthy, HIV-uninfected men and women were randomized one four oral regimens fixed-dose TDF 300 mg/FTC 200 mg tablet 5 weeks with all doses observed: weekly (one/week), twice (two/week),...
Individual or multiple resistance to clindamycin, tetracycline, erythromycin, levofloxacin, mupirocin was detected in a large proportion of methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at an ambulatory health center Boston. The and genes identified these are commonly associated with plasmids.
The ADVANCE (Accelerating Data Value Across a National Community Health Center Network) clinical data research network (CDRN) is led by the OCHIN Information Network in partnership with Choice and Fenway Health. CDRN will 'horizontally' integrate outpatient electronic health record for over one million federally qualified center patients, 'vertically' hospital, plan, community these often under-represented studies. Patient investigators, academic investigators diverse expertise work together...
Objective: To determine the willingness of populations at high risk HIV-1 infection to participate in HIV vaccine efficacy trials, factors influencing decision-making, and evaluate knowledge levels trial concepts. Design: Cross-sectional study. Methods: HIV-1-negative homosexual men, male female injecting drug users non-injecting women heterosexual were recruited eight cities United States (n = 4892). Results: A substantial proportion study population (77%) would definitely (27%) or probably...
Objective: To determine the efficacy of ciprofloxacin therapy in eradicating convalescent fecal excretion salmonellae after acute salmonellosis. Design: Randomized, placebo-controlled, double-blind trial ciprofloxacin, with prospective follow-up nonparticipants. Setting: An care community hospital experiencing an outbreak Patients: Twenty-eight health workers developed infection Salmonella Java; 15 participated a placebo-controlled beginning on day 9 infection. Interventions: Eight patients...
The primary prevention of HIV infection remains a crucial priority; with 2.7 million new infections world wide in 2008, the rate continues to outpace at which HIV-positive individuals enter treatment.1 In recent years, research has focused on variety biomedical strategies for preventing infection, such as male circumcision, vaccines, topical microbicides, and pre-exposure prophylaxis (PrEP) using antiretroviral (ARV) drugs.2 PrEP entails providing HIV-negative ARV drugs, it is widely...
This study examines awareness of and experiences with post-exposure prophylaxis (PEP) pre-exposure (PrEP) among 228 men recruited in Boston, Pittsburgh, San Juan between 12/2010 6/2012. All them reported having condomless anal sex a man the prior year. Overall, 41% had heard PEP, ranging from 16% to 64% Boston. Only 21% PrEP, 8% 36% Three used none PrEP. After methods were described participants, interest both was high, intentions use PEP PrEP respectively at 9.1 7.7 (10-point scale)....
Background Pre-exposure prophylaxis (PrEP) is a promising strategy for HIV prevention among men who have sex with (MSM) and engage in work. But access will require routine testing contacts healthcare providers. This study investigated men's experiences to inform PrEP implementation. Methods We conducted 8 focus groups (n = 38) 2012 56 in-depth qualitative interviews 2013–14 male workers (MSWs) 31) other MSM 25) Providence, RI. MSWs primarily met clients street-based work venues. Facilitators...
Pre-exposure prophylaxis (PrEP) has the potential to reduce transmission of HIV among Black cisgender women in Southern United States (U.S.); however, national data suggests that PrEP initiation is lowest South and compared other U.S. regions white women. This study applied intersectionality multilevel resilience frameworks assess how socio-structural clinical contexts shaped persistence Mississippi. Semi-structured interviews were conducted with eight Jackson, sample was purposively...
Abstract Questions exist about whether testing of preventive human immunodeficiency virus (HIV)-1 vaccines, which will require rapid recruitment and retention cohorts with high HIV-1 seroincidence, is feasible in the United States. A prospective cohort study was conducted 1995–1997 among 4,892 persons at risk for HIV infection nine US cities. At 18 months, an 88% rate, 90 incident infections were observed (1.31/100 person-years (PY), 95% confidence interval (CI): 1.06, 1.61). seroincidence...
Non-occupational post-exposure prophylaxis (nPEP) use is an HIV prevention strategy that has been recommended by the CDC to prevent infection after a high risk sexual exposure since 1997. In behavioral intervention trial of 4,295 MSM we assessed perceptions and nPEP over 4 years in six cities across United States. Overall, 1.9% reported prior enrollment, 6.3% at least once during trial. Awareness was 47.5%, with higher awareness two sites funded programs. Three seroconversions occurred 384...
Background. Blinded clinical trials have reported a modest and transient "start-up syndrome" with initiation of tenofovir-based pre-exposure prophylaxis (PrEP). We evaluate this phenomenon its effect on adherence in an open-label PrEP study. Methods. In the iPrEx extension (OLE) study, 18-month open-label, multi-site cohort taking daily oral co-formulated tenofovir/emtricitabine, we examined prevalence duration PrEP-associated symptoms their adherence, assessed by drug levels dried blood...