A5037076927- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Herpesvirus Infections and Treatments
- Genital Health and Disease
- Bacterial Infections and Vaccines
- Cervical Cancer and HPV Research
- Opioid Use Disorder Treatment
- Amoebic Infections and Treatments
- Substance Abuse Treatment and Outcomes
- Poxvirus research and outbreaks
- Reproductive Health and Contraception
- Prenatal Substance Exposure Effects
- Clostridium difficile and Clostridium perfringens research
- Homelessness and Social Issues
- Blood groups and transfusion
- Maternal Mental Health During Pregnancy and Postpartum
- Bacillus and Francisella bacterial research
- Insects and Parasite Interactions
- Hepatitis B Virus Studies
- Drug-Induced Adverse Reactions
- Colorectal and Anal Carcinomas
- Legionella and Acanthamoeba research
Wake Forest University
2016-2025
Guilford County Schools
2020-2024
Forsyth County Schools
2024
Stanford University
2010-2021
San Mateo County Health System
2021
Atrium Health Wake Forest Baptist
2019-2021
GTx (United States)
2021
BackgroundEstimates of the case hospitalization rate and fatality when hospital care is available for monkeypox (MPX) infections have not been well defined. This rapid systematic review meta-analysis aimed to estimate hospitalisation where available.MethodsWe systematically searched PubMed, Embase, Lancet Preprints, MedRxiv studies published between Jan 1, 1950 Aug 2, 2022. We included documents which contained both number cases associated hospitalisations MPX infections. From eligible we...
Importance Syphilis rates have been increasing in the US for past decade. The incidence of Jarisch-Herxheimer reaction (JHR) after penicillin treatment early syphilis is reported to range from 8% 56%. Objectives To prospectively assess JHR signs and symptoms among adults with treated benzathine G document factors associated response outcomes. Design, Setting, Participants main study was designed as a phase 4 randomized clinical trial compare efficacy 1 vs 3 doses syphilis, measured serologic...
Antimicrobial resistance in Mycoplasma genitalium (MG), a cause of urethritis, is growing concern. Yet little known about the geographic distribution MG United States or its associated clinical outcomes. We evaluated frequency among men with mutations, and posttreatment symptom persistence.We enrolled presenting urethritis symptoms to 6 US sexually transmitted disease (STD) clinics during June 2017-July 2018; were eligible for follow-up contact and, if they had persistent MG, chart review....
<h3>Importance</h3> Rates of chlamydial and gonococcal infection continue to increase in the United States, as do associated costs untreated infections. Improved diagnostic technologies that support testing treating 1 clinical visit are critical advancing efforts control rates infection. <h3>Objective</h3> To evaluate performance a point-of-care (POC) molecular assay for detection chlamydia gonorrhea. <h3>Design, Setting, Participants</h3> A noninterventional, cross-sectional study was...
Mycoplasma genitalium (MG) is on the CDC Watch List of Antimicrobial Resistance Threats, yet there no systematic surveillance to monitor change.We initiated in sexual health clinics 6 cities, selecting a quota sample urogenital specimens tested for gonorrhea and/or chlamydia. We abstracted patient data from medical records and detected MG macrolide-resistance mutations (MRMs) by nucleic acid amplification testing. used Poisson regression estimate adjusted prevalence ratios (aPRs) 95% CIs,...
Abstract Background Enteric pathogens are often associated with exposure to food, water, animals, and feces from infected individuals. However, in sexual networks of men who have sex (MSM), transmission enteric may occur during direct or indirect oral–anal contact. Methods We performed a scoping review the literature for studies prior July 2019 key terms gastrointestinal syndromes (“proctitis,” “enteritis,” “proctocolitis”), sexually transmitted infections (STIs), outbreaks using multiple...
Background: Core groups, characterized by high levels of sexual activity and disease prevalence, are critical to the transmission dynamics sexually transmitted infections (STIs) like gonorrhea. Understanding core group is essential for developing targeted interventions understanding their potential effect on outcomes We assessed composition among gonorrhea cases in Guilford County, North Carolina, where rates elevated, antimicrobial resistance a growing concern. Methods: used Neisseria...
Naloxone is a life-saving medication for opioid overdose, which claims many lives annually. This study investigated provider attitudes about, beliefs and barriers to naloxone use inform an increase in prescription of naloxone. The survey took place at large Southern tertiary health center. An adapted REDCap utilizing validated questions was distributed via institutional e-mail listservs. results (N = 181) were analyzed using descriptive chi-square statistics. While 90.9% the providers had...
Phaeoacremonium parasiticum is an environmental fungus usually associated with subcutaneous infections. We report the first documented case of central nervous system involvement brain abscess formation in a patient chronic granulomatous disease and review literature on
In 2016, Centers for Disease Control and Prevention initiated Strengthening the US Response to Resistant Gonorrhea (SURRG) in multiple jurisdictions enhance antibiotic resistant gonorrhea rapid detection response infrastructure evaluate impact of key strategies.Eight were funded establish or local gonococcal culture specimen collection sexually transmitted disease community clinics, conduct antimicrobial susceptibility testing (AST) laboratories, modify systems enhanced data communication...
For persons living with HIV, health-related quality of life (HRQOL) may be threatened by physical and mental conditions but protected positive psychological traits. We performed an exploratory look at the risk protective factors for HRQOL in older adults HIV. Cross-sectional analyses baseline data from Rush Center Excellence on Disparities HIV Aging (CEDHA), a community-based cohort ages ≥50 (n = 176) were performed. Analyses examined relationship between risk/protective two outcomes (i.e.,...
Objective: To assess differences in anal cancer incidence between racial/ethnic groups among a clinical cohort of men with HIV who have sex men. Design: Clinical study Methods: We studied (MSM) the Centers for AIDS Research Network Integrated Systems (CNICS) initiated antiretroviral therapy (ART) under care CNICS. compared Black and non-Black calculated hazard ratios controlling demographic characteristics (age, CNICS site, year ART initiation), disease indicators (nadir CD4 + , peak RNA),...
High-risk human papillomavirus anal infections are common in immunodeficiency virus-infected women. We conducted a cross-over study 30 women seen California virus clinic, to test the feasibility of self-performed Pap smears. Women found tests acceptable and feasible. Compared with physician-collected specimens, results were highly concordant for cytology (κ = 0.53) high-risk typing 0.59 inclusive equivocal results, or κ 0.81 excluding results).
Disease intervention specialists (DIS) provide partner services for sexually transmitted infections (STIs). We assessed an expansion of DIS clients with HIV and/or syphilis, and contacts within their social sexual networks.Black Latinx cisgender men transgender women who have sex diagnosed syphilis in 4 urban North Carolina counties were referred to designated DIS, trained recruit as "seeds" chain-referral sampling sociosexual network "peers." All received HIV/STI testing care; referrals...
There is an unmet need for developing drugs the treatment of gonorrhea, due to rapidly evolving resistance Neisseria gonorrhoeae against antimicrobial used empiric therapy, increase in globally reported multidrug resistant cases, and limited available therapeutic options. Furthermore, few are under development. Development antimicrobials hampered by challenges clinical trial design, limitations diagnostics, changes varying standards care, lack robust animal models, clinically relevant...
Abstract Background Syphilis rates in the United Stated (U.S.) have increased steadily for over a decade. Despite 75 years as drug of choice syphilis treatment, controversy persists on optimal duration therapy with benzathine penicillin G (BPG) persons early(primary, secondary, and early latent) syphilis, particularly co-infected HIV. Given ongoing national shortages BPG, optimizing is an urgent concern. Methods We conducted multicenter RCT comparing single intramuscular (IM) injection 2.4...
Abstract Background Neisseria gonorrhoeae culture is necessary to determine antimicrobial resistance, but typically requires specimen collection by clinicians. We sought the sensitivity of patient-collected specimens for N. culture. Methods performed cultures on paired clinician- and from pharynx (n = 93), rectum 88), endocervix/vagina 89), urethra/urine 46). calculated percent concordance kappa statistics paired-specimen results, determined test each type using positivity either in a pair...
Abstract We report on the first high-level azithromycin-resistant Neisseria gonorrhoeae isolate (minimum inhibitory concentration, ≥256 μg/mL) in North Carolina isolated from a pharyngeal swab of 33-year-old HIV-negative man who has sex with men. In addition, was found to be susceptible cefixime, ceftriaxone, and penicillin resistant tetracycline. By whole-genome sequencing, strain assigned as MLST ST9363, NG-MAST ST5035, novel NG-STAR sequence type, ST1993.
Abstract Secondary syphilis may mimic sarcoidosis due to atypical clinical and pathological presentations. Differential diagnosis of these two is critical since the courses treatments are different. Highly suspicion utilization confirmatory tests in high‐risk patients key for differential diagnosis.
We describe a case of persistent 5-nitroimidazole-resistant trichomoniasis cured after 14 days oral secnidazole and intravaginal boric acid. Secnidazole may be an important treatment option for resistant trichomoniasis, particularly in women who fail other regimens, including higher doses metronidazole tinidazole longer durations time.
Abstract Neisseria gonorrhoeae osteomyelitis is a rare complication of disseminated gonococcal infection. As the rates N. continue to increase in United States, clinicians may encounter patients with infection complicated by osteomyelitis. Screening and appropriate treatment remains paramount, especially growing antibiotic resistance.
Jurisdictions participating in Strengthening the US Response to Resistant Gonorrhea (SURRG) implemented specimen collection for culture and antimicrobial susceptibility testing from a sample of persons all genders (at multiple anatomic sites) attending sexually transmitted disease clinics community clinics. We describe percentage characteristics patients whose isolates demonstrated reduced (RS) azithromycin, ceftriaxone, or cefixime.