A5058668239- Skin Protection and Aging
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Porphyrin Metabolism and Disorders
- Acne and Rosacea Treatments and Effects
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Occupational exposure and asthma
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer and Skin Lesions
- Skin and Cellular Biology Research
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Circadian rhythm and melatonin
Salford Royal Hospital
2009-2025
Manchester Academic Health Science Centre
2019-2024
NIHR Manchester Biomedical Research Centre
2024
University of Manchester
2007-2024
Salford Royal NHS Foundation Trust
2019
Background Solar urticaria is a rare photodermatosis characterised by rapid onset sunlight-induced urticaria, but its pathophysiology not well understood. Objective To define the cutaneous cellular and molecular events in evolution of solar following initiation simulated ultraviolet radiation (SSR), compare with healthy controls (HC). Methods Cutaneous biopsies were taken from unexposed skin exposed to single low (physiological) dose SSR, at 30 minutes, 3 24 hours post-exposure, n=6 patients...
Solar urticaria (SU) is a rare photodermatosis characterised by abnormal immune responses to specific wavelengths of solar radiation with release histamine and other mediators from cutaneous mast cells. Clinically, it manifests within minutes sun exposure, causing erythemal flares wheals that persist for up 24 hours, as well occasional angioedema. To date, few studies have the SU phenotype in large disease cohorts. As part wider genetic investigation SU, this descriptive cross-sectional...
Importance Photoaggravated atopic dermatitis (PAD) is estimated to affect 1.4% 16% of patients with AD but remains poorly characterized limited published data. Objective To provide detailed clinical and photobiological characterization PAD. Design, Setting, Participants This case series study used cross-sectional data collected from 120 consecutive diagnosed PAD January 2015 October 2019 at a tertiary center referral unit for photobiology. Main Outcomes Measures Routinely standardized were...
Abstract: Milia are keratin containing dermal cysts and seen very frequently in neonates. They generally resolve spontaneously within the first few months of life. However, presence congenital milia may also be associated with a number inherited disorders. We present family no other abnormalities whom were profuse more persistent than usual. A disorders which discussed.
This patient perspective on solar urticaria demonstrates some of the key clinical characteristics and impact urticaria, as well a first-hand account transformative potential omalizumab therapy. The clinicians’ comment reviews features aspects diagnosis management.
Abstract Solar urticaria (SU) is a rare immunologically mediated photodermatosis caused by abnormal cutaneous mast cell degranulation following exposure to solar radiation. It manifests as the rapid development of erythemal flares, weals and/or angio-oedema sunlight and associated with anaphylaxis-like symptoms in severe cases. Unsurprisingly, it has significant impact on patients’ quality life. As part genetic investigation SU pathobiology, we have undertaken descriptive cross-sectional...
Abstract Afamelanotide, a potent analogue of α-melanocyte-stimulating hormone, is known to stimulate melanogenesis by binding the melanocortin 1 receptor. Additionally, in experimental models it has anti-inflammatory and antioxidative effects. Consequently, afamelanotide employed under development as therapeutic agent for patients with photodermatoses, who can experience debilitating effects from exposure sunlight’s ultraviolet radiation (UVR) visible light. However, limited knowledge exists...
Abstract Photoaggravated atopic dermatitis (PAD) is a subtype of (AD) that exacerbated or provoked by exposure to ultraviolet radiation. However, its early pathomechanisms are poorly understood. Our aims were (i) investigate cutaneous clinical, barrier, cellular and molecular changes in the evolution PAD following low-dose solar simulated radiation (SSR) exposure, (ii) compare findings healthy controls exposed same SSR challenge. Three consecutive daily (10 J cm−2) exposures delivered upper...
光照性皮肤病或光敏感性疾病是一组由日晒引起的皮肤疾病,总体影响大量人群。它们会引起一系列令人痛苦的症状(包括疼痛和烧灼),并可使皮肤出现水疱、鳞片和瘢痕。病情本身以及患者逃避阳光和保护自己避免日晒的需求可能会影响生活质量和心理健康。 这项来自英国的研究旨在了解使用哪种评估方法(工具)来评估光照性皮肤病患者的生活质量和心理健康,并报告对患者的影响。 作者回顾了相关的已发表英语类研究并总结了他们的发现。包括 20 项研究:19 项评估生活质量,3 项评估心理功能。使用 6 种不同的工具评估生活质量,以及 4 种不同的工具来评估心理健康。 研究显示,31‐39% 的光照性皮肤病患者的生活质量受到了非常大的影响。对与雇佣、社交/休闲活动和服装选择有关的问题有特殊影响。 尽管只有少数几项研究关注心理健康,但仍然发现患者出现焦虑和抑郁的比率约为一般人群的两倍。作者还指出,大多数可用工具并非旨在评估间歇性光照性皮肤病的独特影响,而且建议开发更特异的工具可能是有益的。 总之,这项研究证实,光照性皮肤病对患者的生活质量有实质性影响,而且需要更多研究。...