A5016185376- Osteoarthritis Treatment and Mechanisms
- Dental Radiography and Imaging
- Bone health and osteoporosis research
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Infrared Thermography in Medicine
- Lower Extremity Biomechanics and Pathologies
- Medical Imaging and Analysis
- Dermatologic Treatments and Research
- Total Knee Arthroplasty Outcomes
- Climate Change and Health Impacts
- Oral microbiology and periodontitis research
- Vitamin D Research Studies
- Coronary Interventions and Diagnostics
- Inflammatory Myopathies and Dermatomyositis
- Thermoregulation and physiological responses
- Forensic Anthropology and Bioarchaeology Studies
- Diagnosis and Treatment of Venous Diseases
- Knee injuries and reconstruction techniques
- Musculoskeletal synovial abnormalities and treatments
- Bone health and treatments
- Skin Protection and Aging
- Skin Diseases and Diabetes
- Morphological variations and asymmetry
University of Manchester
2010-2022
Manchester Academic Health Science Centre
1999-2022
Salford Royal Hospital
2018-2022
Salford Royal NHS Foundation Trust
1999-2020
NIHR Oxford Musculoskeletal Biomedical Research Centre
2017
Versus Arthritis
2012-2013
Academic Center for Dentistry Amsterdam
2008-2009
KU Leuven
2008-2009
National and Kapodistrian University of Athens
2008-2009
Malmö University
2008-2009
Objective Braces used to treat (PF) osteoarthritis (OA) may reduce contact stress across the PF joint. We hypothesised that in OA, braces would decrease knee pain and shrink bone marrow lesions (BMLs). Methods Eligible subjects had painful OA. Subjects were randomly allocated brace or no for 6 weeks. Knee MRIs acquired at baseline measured BMLs on post-contrast fat suppressed sagittal proton density weighted axial images. The primary symptom outcome was change weeks during a preselected...
Synovitis occurring frequently in osteoarthritis (OA) may be a targeted outcome. There are no data examining whether synovitis changes following intra-articular intervention.Persons aged 40 years and older with painful knee OA participated an open label trial of steroid therapy. At all time points they completed the Knee Injury Osteoarthritis Outcome Score (KOOS) questionnaire. They had contrast-enhanced (CE) MRI immediately prior to injection repeat scan within 20 days. Response status was...
Objective Reliable and objective outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis ( SS c)–related Raynaud's phenomenon RP ) are badly needed. Laser speckle contrast imaging LSCI thermography noninvasive perfusion that have shown excellent potential. This multicenter study was undertaken determine the reliability validity a hand cold challenge protocol using , standard thermography, low‐cost cell phone/mobile phone (henceforth referred as mobile...
<h2>Summary</h2><h3>Objective</h3> Synovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness static synovial volume measures to changes enhancement, that are strongly related vascularity. <h3>Methods</h3> Ninety three underwent DCE-MRI 1–2 weeks intra-articular injection 80 mg methylprednisolone. was...
Vitamin D is essential for bone health in adolescence, when there rapid mineral content accrual. Because cutaneous sun exposure provides vitamin D, no recommended oral intake UK adolescents.Our objective was to assess seasonal status and its contributors white Caucasian adolescents examine those found deficient.Prospective cohort study undertaken.Six schools Greater Manchester, UK, were included.Participants 131 between 12 15 years of age.Seasonal assessment circulating 25-hydroxyvitamin...
Objectives: In this study age and the trabecular pattern present on dental radiographs were used to predict presence of osteoporosis. The objective was evaluate contribution prediction. Methods: project, 671 women between 45 71 years recruited. Medical history obtained made. Bone mineral density (BMD) measured at three sites assess osteoporosis according World Health Organization criteria. subjected image analysis methods yielding measurements pattern. Thereafter, discriminant by means age....
To determine the diagnostic accuracy of mandibular and maxillary bone density in detecting osteoporosis using receiver operating characteristic (ROC) analysis.671 women between 45 years 70 age underwent dual energy X-ray absorptiometry (DXA) hip lumbar spine. This was gold standard for diagnosing osteoporosis. Intraoral radiography upper lower right premolar region performed, an aluminium wedge as a densitometric reference. Jaw determined dedicated software. Observer differences ROC curves...
Low vitamin D status is prevalent in wintertime populations at northerly latitudes. Photosensitive patients are advised to practise sun avoidance, but their sunlight exposure levels, photoprotective measures and resulting unknown. To examine seasonal photosensitive relative healthy individuals assess quantitatively behavioural demographic contributors. This was a longitudinal prospective cohort study (53·5°N) examining year‐round 25‐hydroxyvitamin [25(OH)D] sun‐exposure behaviour oral intake...
Polarisation-sensitive optical coherence tomography (PS-OCT) offers a novel, non-invasive method of assessing skin fibrosis in the multisystem disease systemic sclerosis (SSc) by measuring collagen retardance. This study aimed to assess retardance as biomarker SSc. Thirty-one patients with SSc and 27 healthy controls (HC) underwent PS-OCT imaging. 'Skin score' was assessed clinical palpation (0-3 scale). A subset ten age/sex-matched HC had biopsy longitudinal Histological assessment included...
Abstract Objectives Universal serial bus (USB) microscopy (capillaroscopy) could provide all rheumatologists with an easy-to-use, low-cost tool to examine the nailfold capillaries facilitate early diagnosis of SSc. The objectives this pilot study were feasibility acquiring and analysing images using USB compare results videocapillaroscopy. Methods Videocapillaroscopy microscope obtained from right left ring fingers 20 patients SSc healthy control subjects. In addition generating panoramic...
Objectives: A previous study showed that the trabecular pattern on dental radiographs correlates with femoral and spinal bone mineral density (BMD). The objective of this was to determine if correlation is affected by size location region interest (ROI). Methods: In a European research project osteoporosis, BMD measured at left hip lumbar spine 525 women. From all subjects, intraoral were made premolar in upper lower jaws. Two ROIs indicated manually each scanned image. smallest involved...
A key unanswered question in systemic sclerosis (SSc) is how microvascular abnormality and fibrosis inter-relate. Our aim was to use state-of-the-art non-invasive imaging methods gain new insights into pathophysiology, comparing patients with different subtypes of SSc, including early dcSSc, not only healthy controls but also causes Raynaud's phenomenon progressing fibrosis.
Importance Photoaggravated atopic dermatitis (PAD) is estimated to affect 1.4% 16% of patients with AD but remains poorly characterized limited published data. Objective To provide detailed clinical and photobiological characterization PAD. Design, Setting, Participants This case series study used cross-sectional data collected from 120 consecutive diagnosed PAD January 2015 October 2019 at a tertiary center referral unit for photobiology. Main Outcomes Measures Routinely standardized were...