A5056511947- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Diabetic Foot Ulcer Assessment and Management
- Musculoskeletal pain and rehabilitation
- Shoulder Injury and Treatment
- Medical and Biological Sciences
- Delphi Technique in Research
- Advanced MRI Techniques and Applications
- Statistical Methods in Clinical Trials
- Musculoskeletal Disorders and Rehabilitation
- Prostate Cancer Diagnosis and Treatment
- Geological Modeling and Analysis
- Sports injuries and prevention
- Advanced Radiotherapy Techniques
- Occupational Health and Performance
- Mobile Health and mHealth Applications
- Lung Cancer Treatments and Mutations
- Archaeological Research and Protection
- Colorectal Cancer Treatments and Studies
- Atomic and Subatomic Physics Research
University of Manchester
2016-2025
Manchester Academic Health Science Centre
2015-2025
Manchester University NHS Foundation Trust
2019-2025
NIHR Manchester Biomedical Research Centre
2019-2025
University of Oxford
2022-2025
Nuffield Orthopaedic Centre
2023-2025
MRC Clinical Trials Unit at UCL
2024
Primary HealthCare
2024
Primary Health Care
2024
Versus Arthritis
2014-2023
Objective Braces used to treat (PF) osteoarthritis (OA) may reduce contact stress across the PF joint. We hypothesised that in OA, braces would decrease knee pain and shrink bone marrow lesions (BMLs). Methods Eligible subjects had painful OA. Subjects were randomly allocated brace or no for 6 weeks. Knee MRIs acquired at baseline measured BMLs on post-contrast fat suppressed sagittal proton density weighted axial images. The primary symptom outcome was change weeks during a preselected...
Synovitis occurring frequently in osteoarthritis (OA) may be a targeted outcome. There are no data examining whether synovitis changes following intra-articular intervention.Persons aged 40 years and older with painful knee OA participated an open label trial of steroid therapy. At all time points they completed the Knee Injury Osteoarthritis Outcome Score (KOOS) questionnaire. They had contrast-enhanced (CE) MRI immediately prior to injection repeat scan within 20 days. Response status was...
Primary objectives: to determine whether local anaesthetic transperineal prostate (LATP) biopsy improves the detection of clinically significant cancer (csPCa), defined as International Society Urological Pathology (ISUP) Grade Group ≥2 disease (i.e., any Gleason pattern 4 disease), compared transrectal ultrasound-guided (TRUS) biopsy, in biopsy-naïve men undergoing based on suspicion csPCa.
Objective. Few if any prevention strategies are available for knee osteoarthritis (OA). In those with symptomatic medial OA, the contralateral may be at high risk of disease, and a reduction in loading that might prevent disease or its progression there. Our aim was to determine how often persons OA on 1 side had either concurrent later side, whether an intervention known reduce affected knees knee. Lateral wedge insoles across but their effect is unknown. Methods. To proportion who...
Wearables provide opportunities for frequent health data collection and symptom monitoring. The feasibility of using consumer cellular smartwatches to information both on symptoms contemporary sensor has not yet been investigated.This study aimed investigate the acceptability capture multiple patient-reported outcomes per day alongside continuous physical activity over a 3-month period in people living with knee osteoarthritis (OA).For KOALAP (Knee OsteoArthritis: Linking Activity Pain)...
Many conservative treatments exist for medial knee osteoarthritis (OA) which aims to reduce the external adduction moment (EKAM). The objective of this study was determine difference between different shoes and lateral wedge insoles on EKAM, angular impulse (KAAI), flexion moment, pain, comfort when walking in individuals with OA. Seventy OA underwent three-dimensional gait analysis five conditions (barefoot, control shoe, typical wedge, supported mobility shoe) pain recorded concurrently....
Bone marrow lesions (BMLs) on MRI are typically subchondral in location, however, a proportion occur at knee ligament attachments and also include cyst-like component. Our aim was to determine whether the volume of BML subtypes synovial tissue (STV) associated with symptoms symptomatic OA.Images were acquired sub-sample who had taken part randomised trial vitamin D therapy OA (UK-VIDEO). Contrast-enhanced (CE) performed annually. In those ≥1 follow-up baseline scan (N = 50), STV assessed....
Studies of lateral wedge insoles (LWIs) in medial knee osteoarthritis (OA) have shown reductions the average external adduction moment (EKAM) but no lessening pain. Some treated patients actually experience increases EKAM which could explain overall absence pain response. We examined whether, with painful OA, were associated Each patient underwent gait analysis whilst walking a control shoe and two LWI's. evaluated relationship between change using Spearman Rank Correlation coefficients...
The aim was to examine if structural factors could affect response intra-articular steroid injections (IASI) in knee osteoarthritis (OA). Persons with painful OA participated an open-label trial of IASI where radiographic joint space narrowing (JSN) and Kellgren-Lawrence (KL) grade, whole-organ magnetic resonance imaging (MRI) scores (WORMS) quantitative assessment synovial tissue volume (STV) were assessed on baseline images. Participants completed the Knee Injury Osteoarthritis Outcome...
<h2>Summary</h2><h3>Objective</h3> Synovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness static synovial volume measures to changes enhancement, that are strongly related vascularity. <h3>Methods</h3> Ninety three underwent DCE-MRI 1–2 weeks intra-articular injection 80 mg methylprednisolone. was...
Lateral wedge shoe insoles decrease medial knee loading, but trials have shown no effect on pain in osteoarthritis (OA). However, loading effects of are inconsistent, and they can increase patellofemoral loading. We undertook this study to investigate the hypothesis that would reduce preselected patients.Among patients with painful OA, we excluded those OA a rating <4 possible 10. further participants who, gait analysis using lateral wedges, did not show at least 2% reduction adduction...
Objective. Clinical examination of the knee is subject to measurement error. The aim this analysis was determine interobserver and intraobserver reliability commonly used clinical tests in patients with osteoarthritis (OA). Methods. We studied subjects symptomatic OA who were participants an open-label trial intraarticular steroid therapy. Following standardization test procedures, 2 clinicians assessed 25 independently at same visit, clinician 88 over interval period 2–10 weeks; both cases...
Delphi surveys are commonly used to prioritise critical outcomes in core outcome set (COS) development. This trial aims compare a three-round (Multi-Round) (MRD) with Real-Time (RTD) the prioritisation of for inclusion COS neonatal encephalopathy treatments and explore whether 'feedback', 'iteration', 'initial condition' effects may occur two survey methods.
Objective Osteoarthritis (OA) is a disease with significant inflammatory component. The aim of this analysis was to determine the relationship between synovial fluid (SF) white blood cell (WBC) count and 2 parameters: severity reduction in knee pain after intraarticular (IA) steroid injection. Methods Subjects painful OA were recruited for participation an open‐label study IA therapy. Information obtained about using Knee Injury Outcome Score (KOOS) questionnaire, proportion subjects...
Data from a recent clinical trial of vitamin D therapy in knee OA suggests that, compared to placebo, may be associated with reduction effusion-synovitis. Our aim was, using contrast-enhanced (CE) magnetic resonance imaging (MRI), examine the effect on synovial tissue volume (STV) and also subchondral bone marrow lesion (BML) men women symptomatic OA. was acquired participants who took part randomised placebo-controlled (UK VIDEO) investigating (800 IU cholecalciferol daily) radiographic...
In osteoarthritis (OA) clinical trials, a pain measure that is most sensitive to change considered optimal. We compared sensitivity of patient-reported outcomes, including patient-preference (where the patient nominates an activity aggravates their pain).We used data from 2 trials patients with confirmed (American College Rheumatology criteria) knee OA: trial brace treatment for patellofemoral OA, and intraarticular steroids in OA. Both reported improvement following treatment. Participants...
Background: The Knee OsteoArthritis, Linking Activity and Pain (KOALAP) study is the first to test feasibility of using consumer-grade cellular smartwatches for health care research. Objective: overall aim was investigate as a novel tool capture data on pain (multiple times day) physical activity (continuously) in patients with knee osteoarthritis. Additionally, KOALAP aimed smartwatch sensor quality assess whether engagement, acceptability, user experience are sufficient future large-scale...