A5058287929- Musculoskeletal pain and rehabilitation
- Orthopedic Surgery and Rehabilitation
- Stroke Rehabilitation and Recovery
- Prostate Cancer Diagnosis and Treatment
- Shoulder Injury and Treatment
- Meta-analysis and systematic reviews
- Cerebral Palsy and Movement Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Erythropoietin and Anemia Treatment
- Tendon Structure and Treatment
- Osteoarthritis Treatment and Mechanisms
- Frailty in Older Adults
- Sports injuries and prevention
- Prostate Cancer Treatment and Research
- Iron Metabolism and Disorders
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Chronic Disease Management Strategies
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Ethics in Clinical Research
- Parkinson's Disease Mechanisms and Treatments
- Mobile Health and mHealth Applications
- Health disparities and outcomes
University of Oxford
2018-2025
Nuffield Orthopaedic Centre
2019-2025
Office for National Statistics
2022
Keele University
2022
University of Exeter
2022
Careers Europe
2021
NIHR Oxford Musculoskeletal Biomedical Research Centre
2021
University of Southampton
2019-2020
Faculty (United Kingdom)
2019
Prostate cancer diagnosis requires biopsy, traditionally performed under local anaesthetic with ultrasound guidance via a transrectal approach (TRUS). Local ultrasound-guided transperineal biopsy (LATP) is gaining popularity in this setting; however, there uncertainty regarding prostate sampling, infection rates, tolerability, side-effects, and cost-effectiveness. TRANSLATE was randomised clinical trial that aimed to compare detection of Gleason Grade Group (GGG) 2 or higher cancer,...
BackgroundCorticosteroid injections and physiotherapy exercise programmes are commonly used to treat rotator cuff disorders but the treatments' effectiveness is uncertain. We aimed compare clinical cost-effectiveness of a progressive programme with single session best practice advice, or without corticosteroid injection, in adults disorder.MethodsIn this pragmatic, multicentre, superiority, randomised controlled trial (2 × 2 factorial), we recruited patients from 20 UK National Health...
Muscle strengthening exercises are one of the interventions frequently prescribed by physiotherapists for adolescents with cerebral palsy (CP). However, there is wide variability in exercise regimes used and limited evidence their effectiveness. The ROBUST trial will assess clinical effectiveness an individually tailored programme, including progressive resistance advice, compared to usual care ambulant spastic CP. We conducting a multicentre, two-arm, parallel group, superiority randomized...
To estimate the effect of a physiotherapist-delivered fall prevention programme for people with Parkinson's (PwP).
BackgroundPatients with Achilles tendon rupture who have non-operative treatment traditionally been treated immobilisation of the in plaster casts for several weeks. Functional bracing is an alternative that allows earlier mobilisation, but evidence on its effectiveness and safety scarce. The aim UKSTAR trial was to compare functional quality-of-life outcomes resource use patients non-operatively cast versus brace.MethodsUKSTAR a pragmatic, superiority, multicentre, randomised controlled...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...
Primary objectives: to determine whether local anaesthetic transperineal prostate (LATP) biopsy improves the detection of clinically significant cancer (csPCa), defined as International Society Urological Pathology (ISUP) Grade Group ≥2 disease (i.e., any Gleason pattern 4 disease), compared transrectal ultrasound-guided (TRUS) biopsy, in biopsy-naïve men undergoing based on suspicion csPCa.
Abstract Background Neurogenic claudication (NC) is a debilitating spinal condition affecting older adults’ mobility and quality of life. Methods A randomized controlled trial 438 participants evaluated the effectiveness physical psychological group intervention (BOOST program) compared to physiotherapy assessment tailored advice (best practice [BPA]) for adults with NC. Participants were identified from clinics (community secondary care) general records 2:1 BOOST program or BPA. The primary...
Dynamic muscle stretching exercises are one of the interventions frequently prescribed by physiotherapists for children with cerebral palsy (CP). However, there is wide variability in exercise regimes used and limited evidence their effectiveness. The SPELL trial will assess clinical effectiveness an individually tailored dynamic programme, compared to usual care ambulant spastic CP. We conducting a multicentre, two-arm, parallel group, superiority randomized controlled trial. recruit aged...
Background Rotator cuff-related shoulder pain is very common, but there uncertainty regarding which modes of exercise delivery are optimal and the long-term benefits corticosteroid injections. Objectives To assess clinical effectiveness cost-effectiveness progressive compared with best-practice physiotherapy advice, or without injection, in adults a rotator cuff disorder. Design This was pragmatic multicentre superiority randomised controlled trial (with 2 × factorial design). Setting Twenty...
Abstract Background/Aims The treat-to-target (T2T) strategy in psoriatic arthritis (PsA) is not commonly implemented routine care primarily due to feasibility and cost concerns. aim of the Multicentre Observational Initiative Treat-to-Target Outcomes Psoriatic Arthritis (MONITOR-PsA) cohort was assess clinical patient-reported outcomes with a pragmatic implementation T2T approach. Methods Patients from rheumatology departments secondary hospitals UK were included if they had diagnosis PsA...
Availability of randomized controlled trial (RCT) protocols is essential for the interpretation results and research transparency.In this study, we determined availability RCT approved in Switzerland, Canada, Germany, United Kingdom 2012. For these RCTs, searched PubMed, Google Scholar, Scopus, registries publicly available corresponding full-text publications results. We proportion RCTs with (1) protocols, (2) citing protocol, (3) providing a link to protocol. A multivariable logistic...
Symptomatic hand osteoarthritis is more common in women than men, and its incidence increases around the age of menopause, implicating oestrogen deficiency. No randomised controlled trials hormone replacement therapy (HRT) have been done people with osteoarthritis. We aimed to determine feasibility acceptability a form HRT (conjugated oestrogens plus bazedoxifene) post-menopausal painful osteoarthritis.The HOPE-e study was randomised, double-blind, placebo-controlled trial, for which we...
Background Achilles tendon rupture affects > 11,000 people each year in the UK, leading to prolonged periods away from work, sports and social activities. Traditionally, ruptured is held still a plaster cast for ≥ 8 weeks. Functional bracing an alternative treatment that allows patients mobilise earlier, but there little evidence about how patients’ recovery. Objectives To measure Tendon Rupture Score, quality of life, complications resource use receiving non-operative treated with...
Abstract Background The TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal Evaluation) trial assesses the clinical and cost-effectiveness of two procedures in terms detection clinically significant prostate cancer (PCa). This article describes statistical analysis plan (SAP) for randomised controlled (RCT). Methods/design is a parallel, superiority, multicentre RCT. Biopsy-naïve men aged ≥ 18 years requiring suspicion possible PCa are (computer-generated 1:1 allocation...
Abstract Background PDSAFE is an individually-tailored, physiotherapist-delivered, balance, strength and strategy training programme aimed at preventing falls among people with Parkinson’s. We evaluated the cost-effectiveness of compared usual care for Parkinson’s higher risk falling, from a UK National Health Service Personal Social perspective. Methods Resource use quality life data (EQ-5D-3L) were collected 238 participants randomised to intervention 236 control, baseline, 3 months, 6...
The aim of this study is to develop and validate two models predict 2-year risk self-reported mobility decline among community-dwelling older adults.We used data from a prospective cohort people aged 65 years over in England. Mobility status was assessed using the EQ-5D-5L question. were based on outcome: Model 1, any at 2 years; 2, new onset persistent problems years. Least absolute shrinkage selection operator logistic regression select predictors. performance C-statistics, calibration...
Abstract Background During the COVID-19 pandemic, social distancing and reduced contact may have affected older adults’ health. Objectives To evaluate perceived impact of on health explore association between outcomes. Design Cross-sectional longitudinal analyses OPAL cohort study. Subjects Community dwelling adults. Methods We sent questionnaires to participants an existing study ( n = 4328). Questions included amount type contact, how often they went outside. Participants rated their...
ObjectivesTo systematically assess the kind of placebos used in investigator-initiated randomized controlled trials (RCTs), from where they are obtained, and hurdles that exist obtaining them.Study Design SettingPubMed was searched for recently published noncommercial, placebo-controlled drug trials. Corresponding authors were invited to participate an online survey.ResultsFrom 423 eligible articles, 109 (26%) corresponding (partially) participated. Twenty-one 102 (21%) reported not matching...
Use of a person's name in text message has been shown to be effective instigating behaviour change. We evaluated the effectiveness personalised (including recipient's name) versus standardised for prompting response from trial participants complete and return postal follow-up questionnaires.