A5053583797- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Periodontal Regeneration and Treatments
- Orthopedic Surgery and Rehabilitation
- Genital Health and Disease
- Foot and Ankle Surgery
- Bone fractures and treatments
- Venous Thromboembolism Diagnosis and Management
University of Oxford
2017-2024
Nuffield Orthopaedic Centre
2019-2024
John Radcliffe Hospital
2017-2020
After surgery for a broken ankle, patients are usually instructed to avoid walking 6 weeks (delayed weight-bearing). Walking 2 after (early weight-bearing) might be safe and preferable rehabilitation strategy. This study aimed determine the clinical cost effectiveness of an early weight-bearing strategy compared with delayed
Abstract Objective To determine whether an injection of platelet rich plasma improves outcomes after acute Achilles tendon rupture. Design Randomised, placebo controlled, two arm, parallel group, participant and assessor masked, superiority trial. Setting Secondary care trauma units across 19 hospitals in the United Kingdom’s health service. Participants Recruitment commenced July 2015 follow-up was completed March 2018. 230 adults aged 18 years over were included, with rupture presenting...
Aims To determine whether platelet-rich plasma (PRP) injection improves outcomes two years after acute Achilles tendon rupture. Methods A randomized multicentre two-arm parallel-group, participant- and assessor-blinded superiority trial was undertaken. Recruitment commenced on 28 July 2015 two-year follow-up completed in 21 October 2019. Participants were 230 adults aged 18 over, with rupture managed non-surgical treatment from 19 UK hospitals. Exclusions insertion or musculotendinous...
Background Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians patients during the lengthy healing period. Current treatment strategies struggle curb burden of this injury on health systems society due rehabilitation, work absence reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown improve mechanobiological properties tendons in laboratory animal studies. The use PRP musculoskeletal...
Background Achilles tendon rupture affects > 11,000 people each year in the UK, leading to prolonged periods away from work, sports and social activities. Traditionally, ruptured is held still a plaster cast for ≥ 8 weeks. Functional bracing an alternative treatment that allows patients mobilise earlier, but there little evidence about how patients’ recovery. Objectives To measure Tendon Rupture Score, quality of life, complications resource use receiving non-operative treated with...
Background Achilles tendon rupture (ATR) has a long healing period, which is challenging for patients and clinicians. Platelet-rich plasma (PRP) an autologous concentration of platelets thought to improve function recovery. Although preliminary research indicated positive effects, there is, as yet, no evidence clinical efficacy from adequately powered robust trials. Objectives The objectives were determine the PRP in with acute ATR using objective mechanical muscle–tendon measure...
Platelet-rich plasma (PRP) is an autologous preparation that has been claimed to improve healing and mechanobiological properties of tendons both in vitro vivo. In this sub-study from the PATH-2 (PRP Achilles Tendon Healing-2) trial, we report cellular growth factor content quality Leukocyte-rich PRP (L-PRP) (N = 103) prepared using a standardized commercial method across 19 different UK centers. Baseline whole blood cell counts (red cells, leukocyte platelets) demonstrated two groups were...
There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking the literature. Here, we describe statistical analysis plan (SAP) Platelet-rich Achilles Tendon Healing 2 (PATH-2) trial. PATH-2 is pragmatic, parallel-group, multi-centre, double-blinded, randomised, placebo-controlled, superiority The study aims to evaluate efficacy of PRP acute tendon rupture terms muscle-tendon function....
Background The PATH-2 trial found no evidence of a benefit Platelet Rich Plasma (PRP) injection versus placebo after Achilles tendon rupture (ATR) at six-months. ATR often leave longer-term functional deficiencies beyond This study aim is to determine if PRP affect outcomes two-years rupture. Study design Randomised multi-centre two-arm parallel-group, participant- and assessor-blinded, superiority trial. Methods Adults with acute managed non-surgically were recruited in 19 UK hospitals from...
Background Disability and slow return to sport work after tendon rupture are major challenges. Platelet Rich Plasma (PRP) is an autologous supraphysiological concentration of platelets from whole blood that has demonstrated positive cellular physiological effects on healing in laboratory conditions but evidence adequately powered robust clinical trials lacking. We aimed determine the efficacy PRP for treatment acute Achilles rupture. Methods In a placebo-controlled, participant-...
Aim Slow recovery and disability after Achilles tendon rupture are major challenges. Platelet Rich Plasma (PRP) is an autologous supraphysiological concentration of platelets from whole blood that has demonstrated positive cellular physiological effects on healing in the laboratory widely used musculoskeletal treatments. However, evidence adequately powered, robust clinical trials lacking. We aimed to determine efficacy PRP for treatment acute rupture. Methods 230 adults starting...
<h3>Introduction</h3> Platelet Rich Plasma (PRP), an autologous supraphysiological concentration of platelets from whole blood, has demonstrated positive cellular and physiological effects on healing in the laboratory. However, evidence robust clinical trials is lacking. We aimed to determine efficacy PRP for treating acute Achilles tendon rupture. <h3>Materials methods</h3> 230 adults starting non-surgical management within 12 days rupture were randomised injection or dry needle insertion,...