A5007851264- Peripheral Neuropathies and Disorders
- Bone fractures and treatments
- Foot and Ankle Surgery
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Orthopedic Surgery and Rehabilitation
- Cardiovascular and exercise physiology
- Orthopedic Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Hip and Femur Fractures
- Cardiovascular Effects of Exercise
- Orthopaedic implants and arthroplasty
- Blood groups and transfusion
- Shoulder Injury and Treatment
- Advanced Causal Inference Techniques
- Mercury impact and mitigation studies
- Sports injuries and prevention
- CAR-T cell therapy research
- Soft tissue tumor case studies
- Heavy Metal Exposure and Toxicity
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Statistical Methods in Clinical Trials
- Retinal and Optic Conditions
Nuffield Orthopaedic Centre
2020-2025
University of Oxford
2020-2025
MRC Clinical Trials Unit at UCL
2022
Loma Linda University
1988-1995
Loma Linda University Medical Center
1995
Community Hospital of Long Beach
1968
Memorial Hospital
1968
BackgroundImmunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses S1 receptor-binding domain (S1-RBD) SARS-CoV-2 spike protein compared with uninterrupted in patients immune-mediated inflammatory diseases.MethodsWe did an open-label, prospective, two-arm, parallel-group, multicentre, randomised, controlled, superiority trial...
After surgery for a broken ankle, patients are usually instructed to avoid walking 6 weeks (delayed weight-bearing). Walking 2 after (early weight-bearing) might be safe and preferable rehabilitation strategy. This study aimed determine the clinical cost effectiveness of an early weight-bearing strategy compared with delayed
Hip fracture is the most common injury requiring treatment in hospital. Controversy exists regarding use of antibiotic loaded bone cement hip fractures treated with hemiarthroplasty. We aimed to compare rate deep surgical site infection patients receiving high-dose dual-antibiotic versus standard care single-antibiotic cement.We included people aged 60 years and older a attending 26 UK hospitals this randomised superiority trial. Participants undergoing cemented hemiarthroplasty were...
BackgroundMethotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate immediately after COVID-19 booster vaccination improved antibody response against S1 receptor binding domain (S1-RBD) SARS-CoV-2 spike protein live neutralisation compared with uninterrupted in patients diseases.MethodWe did multicentre, open-label, parallel-group, randomised, superiority trial secondary-care...
Objective Methotrexate is first-line treatment for many immune-mediated inflammatory diseases. However, it inhibits vaccine-induced immunity – a major concern this vulnerable group of patients. We evaluated if 2-week interruption methotrexate immediately after COVID-19 booster improved antibody response against spike protein the receptor binding domain and live virus neutralisation (ancestral Wuhan Omicron BA.1) in patients with Design Open-label, prospective, individually randomised,...
To assess the quality of reporting RCT protocols approved by UK research ethics committees before and after publication Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline.We had access to study that received ethical approval in 2012 (n=103) 2016 (n=108). From those, we assessed adherence 33 SPIRIT items (i.e. a total 64 components items). We descriptively analysed guidelines as proportion adequately reported (median interquartile range [IQR]) stratified...
Unstable ankle fractures represent a substantial burden of disease, accounting for mean hospital stay nine days, cost £4,491 per patient and 20,000 operations year. There is variation in UK practice around weight-bearing instructions after operatively managed fracture. Early may reduce reliance on health services, time off work, improve functional outcomes. However, concerns remain about the potential complications such as implant failure. This protocol multicentre randomised non-inferiority...
Aims The management of fractures the medial epicondyle is one greatest controversies in paediatric fracture care, with uncertainty concerning need for surgery. British Society Children’s Orthopaedic Surgery prioritized this as their most important research question trauma. This protocol a randomized controlled, multicentre, prospective superiority trial operative fixation versus nonoperative treatment displaced fractures: or Cast EpicoNdyle Elbows (SCIENCE) trial. Methods Children aged seven...
Aims The primary aim of this study was to assess the feasibility recruiting and retaining patients a patient-blinded randomized controlled trial comparing corticosteroid injection (CSI) autologous protein solution (APS) for treatment subacromial shoulder pain in community care setting. focused on recruitment rates retention participants throughout, collected data interventions’ safety efficacy. Methods Participants were recruited from two musculoskeletal centres UK. Patients eligible if aged...
We determined the effect of hemodilution and hypertension on cerebral hemorrhage brain injury in 32 rats subjected to 180 minutes middle artery occlusion 120 reperfusion. divided into four groups. In control group (n = 8) neither hematocrit nor blood pressure was manipulated during occlusion, 5% albumin administered maintain a 30% mean arterial increased 30 mm Hg above baseline with phenylephrine, hemodilution/hypertension phenylephrine were employed simultaneously occlusion. assessed amount...
Abstract Background Despite favourable outcomes relatively few surgeons offer high tibial osteotomy (HTO) as a treatment option for early knee osteoarthritis, mainly due to the difficulty of achieving planned correction and reported soft tissue irritation around plate used stablise osteotomy. To compare mechanical safety new personalised 3D printed device, created overcome these issues, with an existing generic case-control in silico virtual clinical trial was conducted. Methods Twenty-eight...
Objective The aim of the Ankle Fracture Treatment: Enhancing Rehabilitation (AFTER) study, a multicentre external pilot parallel-group randomised controlled trial (RCT), was to assess feasibility definitive comparing rehabilitation approaches after ankle fracture. Setting Five UK National Health Service hospitals. Participants were aged 50 years and over with an fracture requiring immobilisation for at least 4 weeks. Interventions allocated 1:1 via central web-based randomisation system to:...
It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate 2-week interruption low-dose weekly methotrexate SARS-CoV-2 boosters enhances the immune response compared with continuing adults autoimmune inflammatory conditions. An open-label, pragmatic, prospective, parallel group, randomised controlled superiority trial internal feasibility assessment and nested...
Aims Ankle fractures are common, mainly affecting adults aged 50 years and over. To aid recovery, some patients referred to physiotherapy, but referral patterns vary, likely due uncertainty about the effectiveness of this supervised rehabilitation approach. inform clinical practice, study will evaluate versus self-directed in improving ankle function for older with fractures. Methods This be a multicentre, parallel-group, individually randomized controlled superiority trial. We aim recruit...
Objective: To establish the feasibility of a randomized, placebo-controlled trial to investigate effect specific immunotherapy bacterial lysate OM-89 (Uro-Vaxom ® ) in reducing frequency urinary tract infections people with neurogenic bladder dysfunction. Design: A parallel-group, double-blind, trial. Setting: Patients at home, recruited through out-patient contact, social media and patient support groups. Subjects: People spinal cord injury, multiple sclerosis, transverse myelitis or cauda...