A5048100317- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Child Nutrition and Water Access
- Erythropoietin and Anemia Treatment
- Erythrocyte Function and Pathophysiology
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- RNA modifications and cancer
- Malaria Research and Control
- interferon and immune responses
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Blood disorders and treatments
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Lysosomal Storage Disorders Research
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Metabolism, Diabetes, and Cancer
University of Oxford
2016-2025
MRC Weatherall Institute of Molecular Medicine
2016-2025
John Radcliffe Hospital
2015-2025
MRC Human Immunology Unit
2016-2025
Medical Research Council
2005-2024
Oxford BioMedica (United Kingdom)
2015-2021
National Institute for Health Research
2015
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2015
Center of Molecular Immunology (Cuba)
2009-2011
Institute of Molecular Medicine
2006
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying severity in an integrated comparison influenza sepsis versus healthy volunteers. identify signatures correlates host response. Hallmarks disease involved cells, their inflammatory mediators networks, including progenitor cells myeloid lymphocyte subsets, features the repertoire,...
Abstract Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although the drivers of post-acute sequelae (PASC) COVID-19 unclear. Here we assessed 214 individuals infected with SARS-CoV-2, varying disease severity, for one year from symptom onset to determine early correlates PASC. A multivariate signature detected beyond two weeks disease, encompassing unresolving inflammation, anemia, low serum iron, altered iron-homeostasis gene expression and emerging stress...
The iron hormone hepcidin correctly identifies African children in whom supplementation is most likely to be beneficial.
Significance Altered iron levels correlate with disease progression in HIV type-1 (HIV-1) infection, and cellular promotes HIV-1 replication. In chronic hepatitis B virus (HBV) C (HCV) infections, increased liver contribute to disease. The peptide hormone hepcidin controls distribution. We find that increases during the acute phase of early predicts later plasma viral set-point, remains high even chronically infected individuals receiving antiretroviral therapy. Conversely is not induced,...
BackgroundHow specific nutrients influence adaptive immunity is of broad interest. Iron deficiency the most common micronutrient worldwide and imparts a significant burden global disease; however, its effects on remain unclear.MethodsWe used hepcidin mimetic several genetic models to examine effect low iron availability T cells in vitro immune responses vaccines viral infection mice. We examined humoral human patients with raised serum caused by mutant TMPRSS6. tested supplementation...
Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron impairs vaccine response whether supplementation improves humoral uncertain. Methods: We performed two studies in southern coastal Kenya. In a birth cohort study, we followed to age 18mo assessed anemia or vaccination predicted three-valent oral polio, diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine, ten-valent pneumococcal-conjugate...
Background: Antenatal anemia is a risk factor for adverse maternal and fetal outcomes prevalent in sub-Saharan Africa. Less than half of antenatal considered responsive to iron; identifying women need iron may help target interventions. Iron absorption governed by the iron-regulatory hormone hepcidin. Objective: We sought characterize changes hepcidin its associations with indexes stores, erythropoiesis, inflammation at weeks 14, 20, 30 gestation assess hepcidin's diagnostic potential as an...
Natural killer (NK) cells are important early responders against viral infections. Changes in metabolism crucial to fuel NK cell responses, and altered is linked dysfunction obesity cancer. However, very little known about the metabolic requirements of during acute retroviral infection their importance for antiviral immunity. Here, using Friend retrovirus mouse model, we show that following increase nutrient uptake, including amino acids iron, reprogram machinery by increasing glycolysis...
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis unclear. Using proteomic data, we predicted neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. Accordingly in mice, hepcidin-mediated substantially reduced numbers granulocytes not monocytes, lymphocytes, or dendritic cells. Neutrophil...