A5003076355- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Immune cells in cancer
- Inflammasome and immune disorders
- Blood disorders and treatments
- Single-cell and spatial transcriptomics
- Erythrocyte Function and Pathophysiology
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Endometriosis Research and Treatment
- interferon and immune responses
- Reproductive Physiology in Livestock
- Sepsis Diagnosis and Treatment
- Vasculitis and related conditions
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Bowel Disease
University of Oxford
2020-2024
Roche (China)
2022
Kennedy Center
2020
Institute of Rheumatology
2020
Dalian Medical University
2016
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis unclear. Using proteomic data, we predicted neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. Accordingly in mice, hepcidin-mediated substantially reduced numbers granulocytes not monocytes, lymphocytes, or dendritic cells. Neutrophil...
Giant cell arteritis (GCA) is a common form of primary systemic vasculitis in adults, with no reliable indicators prognosis or treatment responses. We used single technologies to comprehensively map immune populations the blood patients GCA and identified CD66b+CD15+CD10lo/–CD64– band neutrophils CD66bhiCD15+CD10lo/–CD64+/bright myelocytes/metamyelocytes be unequivocally associated both clinical phenotype response treatment. Immature were resistant apoptosis, remained vasculature for...
Excessive neutrophil infiltration and dysfunction contribute to the progression severity of hyper-inflammatory syndrome, such as in severe COVID19. In current study, we re-analysed published scRNA-seq datasets mouse human neutrophils classify compare transcriptional regulatory networks underlying differentiation inflammatory responses. Distinct sets TF modules regulate maturation, function, responses under steady state conditions. COVID19 patients, activation was associated with selective...
Cytokine-like protein 1 (Cytl1), originally described as a expressed in CD34+ cells, was recently identified functional secreted involved chondrogenesis and cartilage development. However, our knowledge of Cytl1 is still limited. Here, we determined the expression pattern regulated by ovarian hormones at both mRNA levels. We found that endometrial mice low before or on first day gestation, significantly increased during embryo implantation, then decreased end implantation. investigated...
Summary Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete understanding potentially druggable immune mediators disease. To advance this, we present a comprehensive multi-omic blood atlas in patients with varying severity compare influenza, sepsis healthy volunteers. We identify signatures correlates host response. Hallmarks disease revealed cells, their inflammatory networks as potential therapeutic targets, including progenitor cells specific myeloid...
During development neutrophils undergo extensive changes in nuclear morphology, gene expression programmes, and acquire specific effector functions. However, molecular mechanisms controlling neutrophil remain largely unknown. Here we systematically analysed chromatin landscape across stages of differentiation, to construct a network transcription factors, predicted control acquisition Zinc finger protein 263 (Zfp263) emerged at the apex this network. Neutrophil maturation ex vivo was blocked...
Summary Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis unclear. Using proteomic data, we predicted neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. Accordingly in mice, hepcidin-mediated substantially reduced numbers granulocytes not monocytes, lymphocytes or dendritic cells....
Abstract Inflammatory bowel disease (IBD) is a group of inflammatory disorders the gastro-intestinal tract caused by complex combination genetic and environmental factors. Interferon regulating factor 5 (IRF5) multifunctional regulator immune responses, which plays key pathogenic role in mouse colitis models risk for IBD. A screen protein kinase inhibitor library macrophages revealed list putative IRF5 kinases. Among top hits validated multiple vitro assays, protein-tyrosine 2-beta (PTK2B or...