A5010526480- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Connective tissue disorders research
- Blood transfusion and management
- Fibroblast Growth Factor Research
- Vitamin D Research Studies
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Genetic Associations and Epidemiology
- Erythropoietin and Anemia Treatment
- Microscopic Colitis
- Healthcare Systems and Technology
- Pharmacological Effects and Toxicity Studies
- Genetic Syndromes and Imprinting
- Dialysis and Renal Disease Management
- Hemoglobin structure and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Causal Inference Techniques
- Vitamin K Research Studies
- Thermal Regulation in Medicine
- Vitamin C and Antioxidants Research
- Long-Term Effects of COVID-19
University of Oxford
2017-2024
Oxford University Hospitals NHS Trust
2020-2022
John Radcliffe Hospital
2020-2022
National Health Service
2021
Abstract Background Optimal prophylactic and therapeutic management of thromboembolic disease in patients with COVID-19 remains a major challenge for clinicians. The aim this study was to define the incidence thrombotic haemorrhagic complications critically ill COVID-19. In addition, we sought characterise coagulation profiles using thromboelastography explore possible biological differences between without complications. Methods We conducted multicentre retrospective observational...
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Abstract In coeliac disease (CeD), immune‐mediated small intestinal damage is precipitated by gluten, leading to variable symptoms and complications, occasionally including aggressive T‐cell lymphoma. Diagnosis, based primarily on histopathological examination of duodenal biopsies, confounded poor concordance between pathologists minimal histological abnormality if insufficient gluten consumed. CeD pathogenesis involves both CD4 + T‐cell‐mediated recognition CD8 γδ inflammation, with a...
Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding.
Coronavirus disease 2019 (COVID-19) mortality is associated with hypoxaemia, multiorgan failure, and thromboinflammation. However severity of varies considerably understanding physiological changes that may link to poor outcomes important. Although increased serum ferritin has been observed in COVID-19 patients consistent inflammation, other iron parameters have not examined our knowledge. Because required for immunity oxygen utilisation, dysregulated homeostasis COPD, we investigated...
Abstract Genome-wide association studies (GWAS) of disease progression are vulnerable to collider bias caused by selection participants with at study entry. This introduces spurious associations between and genetic variants that truly only associated incidence. Methods statistical adjustment reduce this have been published, but rely on assumptions regarding the correlation incidence which likely be violated in many human diseases. MR-Horse is a recently published Bayesian method estimate...
Abstract Fibroblast growth factor 23 (FGF-23) is associated with a range of cardiovascular and non-cardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomisation approaches can help control for such confounding. SCALLOP consortium data on 19,195 participants were used to generate an FGF-23 genetic score. Data from 337,448 UK Biobank estimate associations between higher genetically-predicted concentration the odds any...