A5051708974- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- COVID-19 and healthcare impacts
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Genital Health and Disease
- Infectious Disease Case Reports and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Trauma and Emergency Care Studies
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Renal and Vascular Pathologies
- Surgical Simulation and Training
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Male Reproductive Health Studies
- Advances in Oncology and Radiotherapy
- PARP inhibition in cancer therapy
- Healthcare cost, quality, practices
University Hospital of Wales
2014-2025
Cardiff and Vale University Health Board
2017-2025
Cardiff University
2019-2025
Institut de Virologie
2021
Institut Jules Bordet
2012-2014
Freeman Hospital
2010
BackgroundAbiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed evaluate long-term and test whether combining abiraterone survival.MethodsWe analysed two open-label, randomised, controlled, phase 3 trials STAMPEDE platform protocol, no overlapping controls, conducted 117 sites in UK Switzerland. Eligible (no age restriction) had...
Prostate cancer diagnosis requires biopsy, traditionally performed under local anaesthetic with ultrasound guidance via a transrectal approach (TRUS). Local ultrasound-guided transperineal biopsy (LATP) is gaining popularity in this setting; however, there uncertainty regarding prostate sampling, infection rates, tolerability, side-effects, and cost-effectiveness. TRANSLATE was randomised clinical trial that aimed to compare detection of Gleason Grade Group (GGG) 2 or higher cancer,...
Primary objectives: to determine whether local anaesthetic transperineal prostate (LATP) biopsy improves the detection of clinically significant cancer (csPCa), defined as International Society Urological Pathology (ISUP) Grade Group ≥2 disease (i.e., any Gleason pattern 4 disease), compared transrectal ultrasound-guided (TRUS) biopsy, in biopsy-naïve men undergoing based on suspicion csPCa.
Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits activation, can prevent or delay metastases.
Abstract Background Accurate grading at the time of diagnosis if fundamental to risk stratification and treatment decision making in patients with prostate cancer. Whilst previous studies have demonstrated significant pathological upgrading downgrading following radical prostatectomy (RP), these were based on historical cohorts do not reflect contemporary patient selection management practices. The aim this national, multicentre observational study was characterise rates factors for after RP...
Abstract Objective The study aims to assess current international clinician attitudes, practices and barriers towards fertility assessment preservation in patients undergoing radical inguinal orchidectomy (RIO) for testicular cancer. Materials methods An online survey of urologists training who perform RIO cancer was developed by the British Association Urological Surgeons (BAUS) Sections Andrology Oncology Urology Researchers Surgical Training (BURST). recruitment process used social media...
Abstract Purpose: The purpose was to investigate combined PARP and androgen inhibition in primary prostate cancer understand the biological mechanisms underlying clinical efficacy, especially absence of mutations homologous recombination (HR) repair pathways. Patients Methods: objective measure inhibition, secondary objectives were assess safety feasibility. Participants received olaparib for 2 weeks before prostatectomy randomly assigned or not (1:1) degarelix. We analyzed diagnostic biopsy...
Aims. In this study we report our results with storage of cryopreserved semen intended for preservation and subsequent infertility treatment in men testicular cancer during the last 18 years. Methods. Cryopreserved 523 was collected between October 1995 end December 2012. Semen 34 (6.5%) used fertilization their partners. They underwent 57 cycles cryopreserved, fresh, and/or donor sperm. Results. A total 557 have decided to freeze before treatment. Seminoma diagnosed 283 (54.1%)...
To determine how clinicians use data in contemporary prostate biopsy reports.A survey was circulated to members of the British Association Urological Surgeons and Uro-oncology Group.Responses were received from 114 respondents (88 urologists, 26 oncologists). Ninety-seven (94%) number positive cores each side 43 (42%) % cores. When determining percentage cores, 72 (71%) would not differentiate between targeted non-targeted samples. If multiple Gleason Scores (GS) included a report, 77 (78%)...
Objectives . To compare prostate cancer detection rates of extended 2D versus 3D biopsies and to further assess the clinical impact this method in day-to-day practice. Methods We analyzed data a cohort 220 consecutive patients with no prior history who underwent an initial biopsy daily practice due abnormal PSA and/or DRE using, respectively, classical new systems. All were done by single experienced operator using same standardized protocol. Results There was significant difference terms...
Abstract Diffusion‐weighted MRI (dMRI) is universally recommended for the detection and classification of prostate cancer (PCa), with PI‐RADS recommendations to acquire b ‐values ≥1.4 ms/μm 2 . However, clinical dMRI suffers from a low signal‐to‐noise ratio (SNR) as consequence prolonged echo times (TEs) attributable limited gradient power in range 40–80 mT/m. To overcome this, systems strong gradients have been designed but so far mainly applied brain. The aim this work was assess...
COVID-19 has resulted in the deferral of major surgery for genitourinary (GU) cancers with exception a high risk progression. We report outcomes GU cancer operations, namely radical prostatectomy (RP), cystectomy (RC), nephrectomy (RN), partial (PN), and nephroureterectomy performed at 13 centres across UK between March 1 May 5, 2020. A total 598 such operations were performed. Four patients (0.7%) developed postoperatively. There was no COVID-19-related mortality 30 d. minimally invasive...
Ventriculoperitoneal (VP) shunt surgery remains the most widely used neurosurgical procedure for management of hydrocephalus. However, complications are common and may require multiple surgical procedures during a patient's lifetime. We report case 29-year-old patient with background Dandy-Walker malformation, occipital encephalocele, recurrent hydrocephalus, spina bifida epilepsy presented VP migration into urinary gastrointestinal tracts. In absence sepsis or peritonism from either bowel...
The objective of this study is to compare the early oncological outcomes delayed (>90 days) versus scheduled (≤90 radical prostatectomy (RP).
Objective To establish the pattern of isotope bone scan ( BS ) positivity in a large contemporaneous cohort patients with newly diagnosed localised prostate cancer and compare European Association Urology EAU guidelines, as imaging guidelines clinical practice for using to stage intermediate‐risk are not uniform literature. Patients Methods All were discussed specialist multidisciplinary team meeting prospectively entered database. categorised based on D'Amico classification. intermediate‐...
Abstract Background Whilst competence in the management of a wide range urological emergencies is requirement for certification urology, many conditions are uncommon and exposure during training may be limited. This prospective observational study sought to evaluate feasibility effectiveness standardised cadaveric emergency urology simulation course aimed at improving operative confidence prior independent on-call practice United Kingdom. Methods A two-day supported by British Association...
To determine the acceptability of a non-invasive urinary biomarker test in place conventional flexible cystoscopy for diagnosis bladder cancer patients referred to Rapid Access Haematuria Clinic (RAHC) with suspected urological malignancy.
It is widely recognised that multidisciplinary team meetings (MDTMs) are the cornerstone of cancer practice in United Kingdom and many countries around world. While MDTMs offer several key benefits to patients, healthcare professionals registration, data audit services, they have over time become too large, onerous ‘transactional’ often discussing cases a pre-determined management plan. In response this growing problem, National Health Service (NHS) England NHS Improvement produced an (MDT)...
35 Background: Novel agents given prior to RP allows the study of drug effect(s) in primary human prostate cancer (PC), supporting future clinical development. Pre-clinical and data (mostly setting castration resistant PC) support PARP ± androgen inhibition as therapy for some patients (pt). We undertook a olaparib (O) degarelix (D) RP. Methods: 20 evaluable (pre post tissue available with 86% dose compliance) pt randomised 1:1 O or O+D. Primary endpoint: measure by IHC. Secondary endpoints...