A5061062896- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Coronary Interventions and Diagnostics
- Nonmelanoma Skin Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Nutrition, Genetics, and Disease
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Mitochondrial Function and Pathology
- Cardiac pacing and defibrillation studies
- Plant Disease Resistance and Genetics
- Antiplatelet Therapy and Cardiovascular Diseases
- Sex and Gender in Healthcare
- Radiology practices and education
- Hematopoietic Stem Cell Transplantation
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Bladder and Urothelial Cancer Treatments
- Cancer and Skin Lesions
- Cervical and Thoracic Myelopathy
- Chemical Reactions and Isotopes
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Diabetes and associated disorders
Institute of Biophysics
2023
Chinese Academy of Sciences
2022-2023
University of Chinese Academy of Sciences
2023
State Key Laboratory of Brain and Cognitive Science
2022
Center for Excellence in Brain Science and Intelligence Technology
2022
Stanford University
2015-2021
Duke University
2017
Stanford Medicine
2017
University of Minnesota
2017
Christ Hospital
2017
Purpose To evaluate the performance of a deep learning convolutional neural network (CNN) model compared with traditional natural language processing (NLP) in extracting pulmonary embolism (PE) findings from thoracic computed tomography (CT) reports two institutions. Materials and Methods Contrast material–enhanced CT examinations chest performed between January 1, 1998, 2016, were selected. Annotations by human radiologists made for three categories: presence, chronicity, location PE....
Abstract Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in United States alone. Previous studies have demonstrated association between 21 distinct genetic loci and BCC risk. Here, we report results a two-stage genome-wide study BCC, totalling 17,187 287,054 controls. We confirm 17 previously reported identify 14 new susceptibility reaching significance ( P <5 × 10 −8 , logistic regression). These newly associated SNPs lie...
Palliative care has the potential to improve for patients and families undergoing high-risk surgery.To characterize use of perioperative palliative its association with family-reported end-of-life experiences who died within 90 days a surgical operation.This secondary analysis administrative data from retrospective cross-sectional patient cohort was conducted in Department Veterans Affairs (VA) Healthcare System. Patients underwent any 227 operations between January 1, 2012, December 31,...
Abstract BACKGROUND Outpatient anterior cervical discectomy and fusion (ACDF) is a promising candidate for US healthcare cost reduction as several studies have demonstrated that overall complications are relatively low early discharge can preserve high patient satisfaction, morbidity, minimal readmission. OBJECTIVE To compare clinical outcomes associated costs between inpatient ambulatory setting ACDF. METHODS Demographics, comorbidities, emergency department (ED) visits, readmissions,...
ABSTRACT Genetic risk scores are an increasingly popular tool for summarizing the cumulative of a set Single Nucleotide Polymorphisms (SNPs) with disease. Typically only SNPs that have reached genome‐wide significance compose these scores. However recent work suggests including additional may aid assessment. In this paper, we used Atherosclerosis Risk in Communities (ARIC) Study cohort to illustrate how one can choose optimal genetic score (GRS). addition P ‐value threshold, also examined...
Background— Measurement of fractional flow reserve (FFR) to guide coronary revascularization lags despite robust supportive data, partly because the handling characteristics traditional pressure wires. An optical pressure-monitoring microcatheter, which can be advanced over a guidewire, facilitates FFR assessment but may underestimate wire–derived FFR. Methods and Results— In this prospective, multicenter trial, 169 patients underwent with wire alone microcatheter wire. independent core...
BackgroundGenome-wide association studies have identified polymorphisms linked to both smoking exposure and risk of lung cancer. The degree which cancer is driven by increased smoking, genetics, or gene–environment interactions not well understood.MethodsWe analyzed associations between 28 single nucleotide (SNPs) previously associated with quantity in 7156 African-American females the Women's Health Initiative (WHI), then main effects top nominally significant SNPs SNPs, cigarettes per day...
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial damage in proteinopathy, little is known about how imported mitochondria. In addition, whether caused by mislocalization of or a side effect mitochondria-mediated degradation remains to investigated. Here, our bioinformatical analyses reveal that mitophagy receptor gene FUNDC1 co-expressed with TDP-43, both expression correlated genes associated import pathway brain samples patients diagnosed proteinopathy....
The Hematopoietic Cell Transplantation (HCT)-Specific Comorbidity Index (HCT-CI) has been extensively studied in myeloablative and reduced-intensity conditioning regimens, with less data available regarding the validity of HCT-CI nonmyeloablative (NMA) allogeneic transplantation. We conducted a retrospective analysis to evaluate association between nonrelapse mortality (NRM) all-cause (ACM) patients receiving total lymphoid irradiation antithymocyte globulin (TLI/ATG) NMA transplantation...
Lung transplant candidates can be waitlisted at more than one center, a practice known as multiple listing. The factors associated with listing and whether modifies waitlist mortality or likelihood of lung is unknown. US were identified either single listed using data from the Scientific Registry Transplant Recipients. Characteristics compared multivariable logistic regression was used to estimate associations Multiple matched combination exact propensity score matching methods. Cox...
Urinary incontinence affects >40% of women in the United States, with an annual societal cost >$12 billion and demonstrated associations depressive symptoms, social isolation, loss work productivity. Weight has been established as exposure that increases urinary risk certain dietary components have associated symptoms. We hypothesized diet plays a key role association between weight US women.This study aimed to examine effect low-fat on postmenopausal post hoc analysis randomized controlled...
Background In previous pilot work we demonstrated that a novel automated signal analysis tool could accurately identify successful ablation sites during Wolff-Parkinson-White (WPW) at single center. Objective We sought to validate and refine this in larger multi-center cohort of children with WPW. Methods A retrospective review was performed data from WPW who underwent two pediatric arrhythmia centers 2008–2015. All patients ≤ 21 years invasive electrophysiology study signals available for...