A5046268711- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- Dental materials and restorations
- HIV/AIDS oral health manifestations
- Endodontics and Root Canal Treatments
- Gut microbiota and health
- Dental Erosion and Treatment
- Dental Radiography and Imaging
- Laser Applications in Dentistry and Medicine
- Nutritional Studies and Diet
- Dental Implant Techniques and Outcomes
- Dental Research and COVID-19
- Streptococcal Infections and Treatments
- Periodontal Regeneration and Treatments
- Diet and metabolism studies
- Nosocomial Infections in ICU
- Innovations in Medical Education
- Nutrition and Health in Aging
- Dental Anxiety and Anesthesia Techniques
- RNA modifications and cancer
- Epigenetics and DNA Methylation
The University of Sydney
2017-2025
Sydney Dental Hospital
2018-2023
Medizinische Hochschule Hannover
2009-2019
Cooperative Trials Group for Neuro-Oncology
2019
Universitätsmedizin Göttingen
2009
University of Lübeck
2004-2008
Kiel University
1999-2008
University Hospital Schleswig-Holstein
2004-2008
Witten/Herdecke University
1995
Abstract Background Poor oral health literacy has been proposed as a causal factor in disparities outcomes. This study aims to investigate (OHL) socially and culturally diverse population of Australian adults visiting public dental clinic Western Sydney. Methods A mixed methods where was assessed using the Health Literacy Dentistry scale (HeLD-14) questionnaire semi-structured interviews explored related knowledge, perceptions attitudes. Interviews were analysed thematic approach. Results...
Abstract Cardiovascular diseases (CVDs) encompass various conditions affecting the heart and its blood vessels are often linked with oral microbes. Our data analysis aimed to identify bacteria from other non-oral sites (i.e., gut, arterial plaque cultured blood) that could be CVDs. Taxonomic profiling identified species level compared Human Oral Microbiome Database (HOMD). The in samples were catalogued, their average frequency calculated for each sample. Additionally, filtered by comparison...
<i>Aim:</i> To establish a fluorescence threshold level that could guide therapeutic Er:YAG laser through caries lesion to determine endpoint of removal. <i>Materials and Methods:</i> A total 65 extracted human teeth, 35 with dentine 30 healthy, were used for this study. An system emitted at wavelength 2.94 µm was used. The equipped feedback system, excitation 655 nm, control the irradiation by laser. evaluated levels 3, 7, 8, 10, 12, 15 20. After treatment teeth...
Peri-implant mucositis and peri-implantitis are highly prevalent biofilm-associated diseases affecting the tissues surrounding dental implants. As antibiotic treatment is ineffective to fully cure biofilm mediated infections, antimicrobial modifications of implants reduce or prevent bacterial colonization called for. Preclinical in vivo evaluation functionality new modified implant materials concerning peri-implant health needed allow progress this research field. For purpose reliable animal...
The aim of the present study was to establish a rodent peri-implantitis model induced by mixed bacterial infection characterized bone loss and semi-quantitative graduation peri-implant inflammation in histological sections.Two titanium implants were implanted Sprague-Dawley rats, bilaterally each maxilla. After 3 weeks healing, rats randomized into three groups according different treatments over next months: Antibiotic-Group with oral lavage antibiotics; Bacteria-Group Streptococcus oralis...
Background: Dietary fibre plays a crucial role in metabolic regulation, inflammation, and microbiome composition. However, its impact on systemic oral health, particularly periodontitis, remains unclear. This study investigated the effects of high- low-fibre diets body composition, glycaemic control, microbiome, metabolome murine model experimental periodontitis. Methods: Thirty-six male C57BL/6 mice were randomised to high-fibre (40% fibre) or (5% diet for eight weeks. Body weight, fat...
To investigate the effects of human beta-defensins on expression genes involved in host immune response dental pulp.Human odontoblast-like cells were cultured Dulbecco's modified Eagle's medium. Cells stimulated by recombinant (rhBDs) up to 4 h. RNA was extracted followed cDNA synthesis (oligo-(dT)-primer). Samples analysed real-time polymerase chain reaction (PCR) technology. Genes interest were: beta-defensin-1, -2, interleukin (IL)-6, IL-8, tumour necrosis factor-alpha, cyclooxygenase-2,...
Background and Objectives In the oral cavity, epithelial surface is constantly exposed to a number of different microorganisms that are organized in well‐structured biofilm. The aim this study was monitor gingival expression antimicrobial peptides ( AMP s) interleukin‐8 IL ‐8) an early gingivitis model. Material Methods Experimental allowed develop healthy volunteers n = 17). Bleeding on probing BOP %) crevicular fluid volume GCF ) were assessed at baseline day 1, 3, 5, 7 14. Expression s...
While periodontal disease is associated with many risk factors, socioeconomically disadvantaged communities experience the highest burden. The aim of this study was to evaluate effectiveness a personalized oral health education program, in combination routine dental treatment, participants from low socioeconomic community. We used randomized, controlled, examiner-blinded clinical trial. A total 579 (aged 18–60 years) were randomly grouped: intervention group (n = 292) received program care...
We have characterized Escherichia coli DNA adenine methyltransferase, a critical regulator of bacterial virulence. Steady-state kinetics, product inhibition, and isotope exchange studies are consistent with kinetic mechanism in which the cofactor S-adenosylmethionine binds first, followed by sequence-specific binding catalysis. The enzyme has fast methyl transfer step slower release steps, we directly demonstrate competence complex. Methylation adjacent GATC sites is distributive derived...
Background/aims: Antimicrobial peptides such as human β‐defensin‐2 (hBD‐2), psoriasin (PSO), and ribonuclease 7 (RNase 7) play an important role in innate immunity. The aim of the present study was to test hypothesis that epithelial cells show a differential gene expression pattern antimicrobial (hBD‐2, PSO, RNase inflammatory mediators interleukin‐8 (IL‐8) 5‐lipoxygenase (5‐LO) response different stages naturally formed biofilms. Methods: Epithelial were cultured from biopsies obtained five...
It has been suggested that laser fluorescence close to the dental pulp shows higher values than more distant measurements. The aim of this study was assess on cavity floor and correlate these measurements with electrical resistance as a measure residual dentine thickness. Thirty carious lesions were excavated bur. endpoint caries removal determined by visual, tactile auditory means. Fluorescence measured Diagnodent device feedback system therapeutic Er:YAG laser. Electrical (Prepometer...
In the oral cavity, surfaces are constantly exposed to a complex variety of microorganisms organized in biofilms. As part sophisticated local immune response, gingival epithelial cells (GECs) express antimicrobial peptides, such as human beta-defensin-2 (hBD-2), ribonuclease 7 (RNAase-7), and psoriasin (PSO), pro-inflammatory mediators, interleukin-8 (IL-8) 5-lipoxygenase (5-LO). The aim present study was test whether GECs show differential response single-species biofilms compared with...
Abstract The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment human trials to investigate whether promotes early stages conditions. Therefore, aim this study was induces endothelial dysfunction in hyperlipidemic apolipoprotein E gene-deficient (ApoE -/- ) mice. Forty-five 8-week-old ApoE mice were challenged by oral lavage with...