Tomas Leng

ORCID: 0000-0001-8069-3393
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About
Contact & Profiles
Research Areas
  • Kawasaki Disease and Coronary Complications
  • Cardiac Arrhythmias and Treatments
  • Central Venous Catheters and Hemodialysis
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac electrophysiology and arrhythmias
  • Trauma Management and Diagnosis
  • Dysphagia Assessment and Management
  • Vascular anomalies and interventions
  • Genomics and Rare Diseases
  • Congenital Heart Disease Studies
  • Long-Term Effects of COVID-19
  • Inflammasome and immune disorders
  • COVID-19 Clinical Research Studies
  • Shoulder Injury and Treatment
  • Neonatal and Maternal Infections
  • Antibiotics Pharmacokinetics and Efficacy
  • Respiratory and Cough-Related Research
  • Pediatric Pain Management Techniques
  • CRISPR and Genetic Engineering
  • Simulation-Based Education in Healthcare
  • Cardiac pacing and defibrillation studies
  • Cardiac Valve Diseases and Treatments
  • Systemic Lupus Erythematosus Research
  • Intensive Care Unit Cognitive Disorders
  • Airway Management and Intubation Techniques

WinnMed
2023-2025

Mayo Clinic in Florida
2023-2025

Mayo Clinic in Arizona
2025

Mayo Clinic
2023-2024

Children's Hospital of Philadelphia
2021

University of Pennsylvania
2021

Philadelphia University
2021

National University of Singapore
1997

Abstract Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild or minimal disease, a small proportion developing disease multisystem inflammatory in (MIS-C). Complement-mediated thrombotic microangiopathy (TMA) has been associated SARS-CoV-2 adults but not studied the pediatric population. We hypothesized that complement activation plays an important role and sought to understand if TMA was present these patients. enrolled 50 hospitalized...

10.1182/bloodadvances.2020003471 article EN cc-by-nc-nd Blood Advances 2020-12-08

Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) infection pediatric patients. Weeks after an often mild or asymptomatic initial with SARS-CoV-2 children may present severe shock-like picture and marked inflammation. MIS-C varying degrees cardiovascular hyperinflammatory symptoms. Here we perform comprehensive analysis the plasma proteome more than 1400 proteins SARS-CoV-2. We hypothesize that would reflect...

10.1038/s41467-021-27544-6 article EN cc-by Nature Communications 2021-12-10

Brain abscess is a serious condition in children, leading to rapid deterioration, and permanent neurological damage associated with significant morbidity mortality. Current management protocols for brain abscesses focus on intravenous antibiotics surgical excision drainage. A 12-year-old adolescent male who had headache photophobia was diagnosed multiple refractory conventional medical neurosurgical intervention. single dose of 10 mg vancomycin administered through endo-ventricular drain,...

10.2478/jccm-2024-0046 article EN ˜The œJournal of Critical Care Medicine 2025-04-01

Abstract Metabolic pathways are known to generate byproducts—some of which have no clear metabolic function and some toxic. Nicotinamide adenine dinucleotide phosphate hydrate (NAD(P)HX) is a toxic metabolite that produced by stressors such as fever, infection, or physical stress. dehydratase (NAXD) nicotinamide epimerase (NAXE) part the repair system break down this metabolite. Deficiency NAXD NAXE interrupts critical intracellular NAD(P)HX allows for its accumulation. Clinically,...

10.1002/ajmg.a.63519 article EN American Journal of Medical Genetics Part A 2024-01-12

Ebstein anomaly is a myopathy of the right ventricle characterized by failure tricuspid valve delamination with accompanying regurgitation. Its rarity, considerable anatomic variability, and frequent absence symptoms can make timing surgery challenging. Contemporary repair techniques be performed low mortality bidirectional cavopulmonary anastomosis reduces risk operation when ventricular function poor. Here, we present patient who presented late for surgery, failed high-risk conventional...

10.1177/21501351241239305 article EN World Journal for Pediatric and Congenital Heart Surgery 2024-05-02

Journal Article ADVANCE MEDICAL DIRECTIVES IN SINGAPORE Get access TER KAH LENG, LENG Associate professor *Faculty of Business Administration, National University Singapore Search for other works by this author on: Oxford Academic PubMed Google Scholar SUSANNA LEONG HUEY SY Lecturer **Faculty Medical Law Review, Volume 5, Issue 1, Spring 1997, Pages 63–101, https://doi.org/10.1093/medlaw/5.1.63 Published: 01 March 1997

10.1093/medlaw/5.1.63 article EN Medical Law Review 1997-01-01

Abstract Background Routine defibrillation threshold testing (DFT) of transvenous implantable defibrillators (ICDs) has largely been in decline. In patients with non‐transvenous ICDs that utilize subcutaneous and pleural ICD leads, serial DFT can detect a significant number failures. Data about the utility follow‐up safety margin (DSM) pediatric young adults an epicardial are lacking. Methods Patients aged < 25 years old who underwent placement at Mayo Clinic from 2014 to 2023 least one...

10.1111/pace.14948 article EN Pacing and Clinical Electrophysiology 2024-02-11

An 11-year-old healthy girl was presented to the ED for evaluation of sternal pain after a fall during gymnastics competition.She landed on her shoulders while attempting back-tuck maneuver (back-flip), resulting in hyperflexion injury anterior chest.POCUS performed awaiting x-ray imaging.A longitudinal panoramic ultrasound view sternum revealed widening sternomanubrial joint (Figure 2).

10.1002/emp2.13160 article EN cc-by-nc-nd Journal of the American College of Emergency Physicians Open 2024-04-01

Penile pain in children and adolescents is an uncommon presenting symptom the emergency department (ED). The differential diagnosis includes trauma, priapism, urethral stone, infection, Mondor disease, Peyronie thrombosis. A 15-year-old male with a high-risk, B-cell acute lymphocytic leukemia recent pegaspargase administration presented to ED new-onset penile pain. After of opioid analgesics, he developed hypoxia prompting urgent computed tomography pulmonary angiogram that revealed...

10.5811/cpcem.21138 article EN cc-by Clinical Practice and Cases in Emergency Medicine 2024-12-06

Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) pandemic pediatric patients. Weeks after an often mild or asymptomatic initial infection with SARS-CoV-2 children may present severe shock-like picture and marked inflammation. MIS-C varying degrees cardiovascular hyperinflammatory symptoms. We performed comprehensive analysis plasma proteome more than 1400 proteins SARS-CoV-2. hypothesized that would...

10.1101/2021.04.13.21255439 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-04-20

Abstract Background Pulmonary embolism (PE) in the pediatric population is uncommon, and due to a silent presentation often unrecognized entity that remains one of most challenging medical conditions emergency department (ED). Risk factors for PE children include nephrotic syndrome, immobility, obesity, congenital heart disease, malignancy. In patients with PE, thromboembolism has been reported occur at unusual venous sites including veins within central nervous system abdomen. Although...

10.21203/rs.3.rs-2610249/v1 preprint EN cc-by Research Square (Research Square) 2023-03-01

Exertional dyspnea is a common and disabling symptom in otherwise healthy children adolescents, as well with baseline airway abnormalities. It impairs the quality of life may be associated fatigue underperformance sports. can caused by wide variety structural psychogenic causes. Exercise-induced laryngeal obstruction (EILO) relatively prevalent entity young people that usually presents exertional stridor, coughing, transient closure larynx. In more complex cases where conventional tests such...

10.7759/cureus.50572 article EN Cureus 2023-12-15
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