Chakkapong Burudpakdee

ORCID: 0009-0006-7100-2590
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About
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Research Areas
  • Acute Lymphoblastic Leukemia research
  • Kawasaki Disease and Coronary Complications
  • Neuroblastoma Research and Treatments
  • COVID-19 Clinical Research Studies
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Impact on Reproduction
  • T-cell and B-cell Immunology
  • Long-Term Effects of COVID-19
  • Lung Cancer Research Studies
  • Graphene and Nanomaterials Applications
  • Vasculitis and related conditions
  • Heat shock proteins research
  • Genetic Neurodegenerative Diseases
  • Complement system in diseases
  • Hedgehog Signaling Pathway Studies
  • Inflammasome and immune disorders
  • Integrated Circuits and Semiconductor Failure Analysis
  • Genetics and Neurodevelopmental Disorders
  • Systemic Lupus Erythematosus Research
  • Glioma Diagnosis and Treatment
  • Autoimmune and Inflammatory Disorders Research
  • Cancer therapeutics and mechanisms
  • Fungal and yeast genetics research

Temple University Health System
2024

Fox Chase Cancer Center
2024

University of Pennsylvania
2020-2022

Philadelphia University
2020-2022

Children's Hospital of Philadelphia
2020-2022

Pace University
2019

BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2) pandemic described children as being less susceptible to disease 2019 (COVID-19) than adults. Subsequently, a and novel pediatric disorder termed multisystem inflammatory syndrome in (MIS-C) emerged. We report on unique hematologic immunologic parameters that distinguish between COVID-19 MIS-C provide insight into pathophysiology.

10.1172/jci140970 article EN Journal of Clinical Investigation 2020-07-30

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present Multisystem Inflammatory Syndrome Children (MIS-C) that can lead to vascular complications shock, but rarely death. The immune features MIS-C compared pediatric or adult remain poorly understood. We analyzed peripheral blood responses hospitalized infected patients (pediatric COVID-19) MIS-C. had patterns T cell-biased...

10.1126/sciimmunol.abf7570 article EN cc-by Science Immunology 2021-03-02

Abstract Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild or minimal disease, a small proportion developing disease multisystem inflammatory in (MIS-C). Complement-mediated thrombotic microangiopathy (TMA) has been associated SARS-CoV-2 adults but not studied the pediatric population. We hypothesized that complement activation plays an important role and sought to understand if TMA was present these patients. enrolled 50 hospitalized...

10.1182/bloodadvances.2020003471 article EN cc-by-nc-nd Blood Advances 2020-12-08

Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) infection pediatric patients. Weeks after an often mild or asymptomatic initial with SARS-CoV-2 children may present severe shock-like picture and marked inflammation. MIS-C varying degrees cardiovascular hyperinflammatory symptoms. Here we perform comprehensive analysis the plasma proteome more than 1400 proteins SARS-CoV-2. We hypothesize that would reflect...

10.1038/s41467-021-27544-6 article EN cc-by Nature Communications 2021-12-10

To study the biology and identify markers of severe cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment.We used comprehensive proteomic profiling to measure over 1,400 serum proteins at multiple serial timepoints a cohort patients with B-cell acute lymphoblastic leukemia treated CD19-targeted CAR T CTL019 on two clinical trials.We identified fms-like tyrosine kinase 3 (FLT3) mast cell...

10.1158/1078-0432.ccr-22-0822 article EN Clinical Cancer Research 2022-06-15

Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared those severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection MIS-C patients.

10.1093/jpids/piaa161 article EN other-oa Journal of the Pediatric Infectious Diseases Society 2020-12-01

Inclusions of disordered protein are a characteristic feature most neurodegenerative diseases, including Huntington’s disease. disease is caused by expansion polyglutamine tract in the huntingtin protein; mutant (mHtt) unstable and accumulates large intracellular inclusions both affected individuals when expressed eukaryotic cells. Using mHtt-GFP Saccharomyces cerevisiae , we find that dynamic, mobile, gel-like structures concentrate mHtt together with disaggregase Hsp104. Although may...

10.26508/lsa.201900489 article EN cc-by Life Science Alliance 2019-09-16

ABSTRACT Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present Multisystem Inflammatory Syndrome Children (MIS-C) that can lead to vascular complications shock, but rarely death. The immune features MIS-C compared pediatric or adult remain poorly understood. We analyzed peripheral blood responses hospitalized infected patients (pediatric COVID-19) MIS-C. had patterns T...

10.1101/2020.09.25.20201863 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-09-27

ABSTRACT SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome (MIS-C) possess higher spike IgG titers compared to those severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection MIS-C patients.

10.1101/2020.08.17.20176552 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-08-18

Neuroblastoma is a commonly lethal solid tumor of childhood and intensive chemoradiotherapy treatment cures ~50% children with high-risk disease. The addition immunotherapy using dinutuximab, monoclonal antibody directed against the GD2 disialoganglioside expressed on neuroblasts, improves survival when incorporated into front-line therapy shows robust activity in regressing relapsed disease combined chemotherapy. Still, many succumb to neuroblastoma progression despite receiving...

10.1080/2162402x.2022.2075204 article EN cc-by-nc OncoImmunology 2022-05-24

Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for activation and possess innate NK-like functional features. Currently, iNKT cell-based immunotherapies remain in early clinical stages, little is known about the ability these to survive retain effector functions within solid tumor microenvironment (TME) long-term. In conventional (T CONV ), cellular metabolism linked their adapt nutrient-poor TME. contrast, bioenergetic requirements –...

10.3389/fimmu.2021.700374 article EN cc-by Frontiers in Immunology 2021-08-09

Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) pandemic pediatric patients. Weeks after an often mild or asymptomatic initial infection with SARS-CoV-2 children may present severe shock-like picture and marked inflammation. MIS-C varying degrees cardiovascular hyperinflammatory symptoms. We performed comprehensive analysis plasma proteome more than 1400 proteins SARS-CoV-2. hypothesized that would...

10.1101/2021.04.13.21255439 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-04-20

<div>AbstractPurpose:<p>To study the biology and identify markers of severe cytokine release syndrome (CRS) immune effector cell–associated neurotoxicity (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment.</p>Experimental Design:<p>We used comprehensive proteomic profiling to measure over 1,400 serum proteins at multiple serial timepoints a cohort patients with B-cell acute lymphoblastic leukemia treated CD19-targeted CAR T CTL019 on two...

10.1158/1078-0432.c.6532275 preprint EN 2023-03-31
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