A5001818342- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Lymphoma Diagnosis and Treatment
- Blood transfusion and management
- Complement system in diseases
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- T-cell and B-cell Immunology
- Blood disorders and treatments
- Organ Donation and Transplantation
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Artificial Intelligence in Healthcare and Education
- Intravenous Infusion Technology and Safety
- Blood donation and transfusion practices
- Viral Infections and Immunology Research
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Renal and related cancers
Sapienza University of Rome
2010-2024
National Blood Transfusion Service
2024
Policlinico Umberto I
2017-2022
BACKGROUND Two noninferiority, randomized, controlled trials were conducted in parallel comparing the safety and efficacy of platelets treated with Intercept or Mirasol pathogen‐reduction technologies versus standard platelets. STUDY DESIGN AND METHODS The primary endpoint was percentage hematology patients who developed World Health Organization Grade 2 greater bleeding. A noninferiority margin 11% chosen based on expected bleeding 20% controls. study closed for financial restrictions...
PURPOSE To evaluate, in a prospective trial, new combination chemotherapy specifically designed for elderly patients. PATIENTS AND METHODS From October 1988 to December 1990, 60 previously untreated patients older than years of age with aggressive non-Hodgkin's lymphoma (NHL) were treated at our institution weekly alternating six-drug regimen, P-VABEC. The schedule consisted doxorubicin, etoposide, and cyclophosphamide alternated vincristine bleomycin. Oral prednisone was administered daily...
In the setting of mismatched-hematopoietic stem cells transplantation, detection antibodies directed against donor-specific HLA allele(s) or antigen(s) (DSA) represents a barrier for engraftment. It is thus necessary to plan an immunosuppressive strategy, select alternative donor. This prospective study aimed at evaluating efficacy our strategy testing DSAs and desensitization (DS) employed between November 2017 2020.
Red blood cell (RBC) autoimmunization is a relatively uncommon cause of anemia in children and presents some differences from those adults. Due to its frequency, autoimmune hemolytic (AIHA) childhood has prompted very few studies, the literature consists mostly sporadic case histories. The objective this study was stress importance an appropriate serologic diagnosis suspected cases.This report describes immunohematologic features 100 patients with AIHA studied Immunohaematologic Unit Blood...
Acute promyelocytic leukemia (FAB-M3) is a distinct entity among acute non-lymphoid leukemias (ANLL) with peculiar morphological, biological, clinical and prognostic features. An atypical form of M3 (M3v) could be confused other FAB ANLL therefore the diagnosis this variant requires ultrastructural analysis and/or cytogenetic study selective gene rearrangement studies. The immunological phenotype blast cells in 39 APL patients was studied at diagnosis. type ascertained 32 M3v 7 cases. Using...
The publication of the second edition “Recommendations for prevention and treatment haemolytic disease foetus newborn” is result collaboration between Italian Society Transfusion Medicine Immunohaematology (SIMTI, Societa Italiana di Medicina Trasfusionale e Immunoematologia) Gynaecology Obstetrics (SIGO, Ginecologia Ostetricia). The recommendations published in 20061 have been revised light current scientific evidence: immunohaematological instrumental investigations that should be...
Background Immunoglobulin ( Ig ) G replacement with intravenous or subcutaneous immunoglobulins is a lifelong substitutive therapy in patients primary antibody deficiencies PADs ). Hemolysis after immunoglobulin was described receiving high dosages. The issue of hemolysis administration at doses has been considered little clinical significance. Study Design and Methods This single‐center observational study over 2‐year period on immunoglobulin‐induced cohort 162 PAD s treated administered...
Frequent blood loss induces progressive depletion of iron stores, leading to deficiency and, ultimately, overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response anaemia is under the control hypoxia-inducible factors (HIF), master regulators oxygen and homeostasis. Since HIF-1α(Pro-582-Ser) variant associated with elevated trans-activation capacity hypoxia responsive elements target genes, we investigated whether polymorphism might influence repeated withdrawals.Using...
Summary Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by the expansion of phosphatidylinositol glycan class A (PIG‐A) defective haematopoietic cells, probably due to immune‐mediated alterations bone marrow environment selecting PIG‐A − stem cells. The present study investigated presence immune system in a population 11 PNH patients. production interferon‐ γ (IFN‐ ) and interleukin‐2 (IL‐2), evaluated intracellular cytokine analysis, frequencies I II human leucocyte antigen...
The authors describe the case of a 75-year-old female who was hospitalized for anemia unknown origin. Physical examination revealed swelling in right mammary region, where mastectomy scar present from surgery breast carcinoma. On admission, laboratory tests disclosed (Hb, 8.5 g/dl), with reticulocyte count 65,000/mm 3 and slightly increased bilirubin. Immunohematologic study presence red cell autoantibody anti-D specificity serum eluate patient's erythrocytes. A biopsy performed histologic...
Paroxysmal cold haemoglobinuria, first described by Donath and Landsteiner in 19041,2, is a rare autoimmune haemolytic anaemia, defined the presence of an IgG biphasic haemolysin. It generally considered acute self-limited anaemia caused auto-anti-P antibody (Donath-Landsteiner [DL]-haemolysin). The autoantibody called because it sensitises red cells at 0–4 °C causes complement-mediated haemolysis higher temperatures. The reported incidence ranges from 1.6 to 5.1% childhood anaemia3,...
The characterization of lymphocyte subsets in blood donors has been utilized to determine the normal ranges that can be related race. A study was performed from two racial groups - Caucasian (Italians) and Asian (Philippinos) define respective T-lymphocyte levels cytokines.Ninety-two (46 Italians 46 Philippinos) were enrolled. Blood count immunophenotyping lymphocytes by flow cytometry carried out, cytokine production tested six each group.Philippino showed a significantly higher mean value...
ABO antibody titres are important in many clinical decisions; however, much variability is observed titre results. For reliable and reproducible results, automated titration methods have been developed. In this 10-site study, we evaluated the equivalency of assays on Galileo NEO, a fully blood bank analyzer (Immucor, Inc.) to manual with gel Column Agglutination Technology (CAT), as well reproducibility both methods.Ten different locations participated study. The study included 70 random...
The impact of ABO incompatibility on the outcome hematopoietic stem cell transplantation (HSCT) is still debated. We report results a prospective, single-center study evaluating mismatch development immediate and late immuno-hematological complications, efficacy protocol used at "Sapienza" University (Rome, Italy) to manage in patients undergoing HSCT.From January 2013 December 2016, we prospectively analyzed all HSCT. Graft manipulation or desensitization strategies were according...
Sometimes commercial RBC sets for the screening of irregular antibodies contain Wr(a+) cells. The aim this study was to define usefulness employing containing cells in pre-transfusion tests. Anti-Wr(a) is a relatively common naturally occurring antibody candidates blood transfusion, although risk receiving non-compatible unit low. We have studied both incidence Wr(a) and effects having cell test on routine work an unselected population 787 patients requiring transfusion 151 new donors....
The high safety of homologous blood components, together with the introduction Patient Blood Management strategy, has led to progressive abandonment preoperative autologous donation (PAD) in surgery. Furthermore, recent scientific publications provide evidence about non-usefulness PAD collection hematopoietic stem cells (HSC) from bone marrow (BM), also consideration harvest procedure safety. Nevertheless, no conclusive studies have been published yet.Blood Establishments (BE) and Bone...