A5080259352- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Ultrasound in Clinical Applications
- Trauma and Emergency Care Studies
- Cardiovascular and Diving-Related Complications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Indoor Air Quality and Microbial Exposure
- Disaster Response and Management
- Antifungal resistance and susceptibility
- Innovations in Medical Education
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational exposure and asthma
- Inflammatory Myopathies and Dermatomyositis
Cleveland Clinic
2016-2025
Einstein Medical Center Philadelphia
2020
Thomas Jefferson University
2020
Cleveland Clinic Lerner College of Medicine
2016
Case Western Reserve University
2016
Johns Hopkins Medicine
2010-2015
Johns Hopkins University
2010-2015
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2014
Universitat de Barcelona
2014
Fundación Alfonso Martín Escudero
2014
In critically ill patients with coronavirus disease 2019, there has been considerable debate about when to intubate acute respiratory failure. Early expert recommendations supported early intubation. However, as we learned more this disease, the risks versus benefits of intubation are less clear. We report our findings from an observational study aimed compare difference in outcomes 2019 who were intubated later course. need for was defined either at admission or within 2 days having a...
Endpoint resuscitation has been suggested as a better means to resuscitate penetrating injury. We performed computer-controlled closed-loop using invasive cardiac output (CO) or noninvasive skeletal muscle oxygen saturation (SkMusSO(2)) via near infrared spectroscopy (NIRS).Conscious sheep received 4.0-mm aortotomy and uncontrolled hemorrhage at t = 0 min (T0) while started T20 lactated Ringer's solution.The rapidly decreased the mean arterial pressure (MAP) approximately 30 mm Hg CO 20% 30%...
African Americans (AA) with systemic sclerosis (SSc) have a worse prognosis compared to of European descent (EA). We conducted the current study test hypothesis that AA patients SSc more severe disease and poorer outcomes EA when afflicted pulmonary arterial hypertension (PAH). studied 160 consecutive PAH diagnosed by right heart catheterization, comparing demographics, hemodynamics, between patients. The cohort included 29 131 similar baseline characteristics except for increased prevalence...
Patients with scleroderma (SSc)-associated pulmonary arterial hypertension (PAH) have worse survival than patients idiopathic PAH (IPAH). We hypothesized that the right ventricle (RV) adapts differently in SSc-PAH versus IPAH. used cardiac magnetic resonance imaging (cMRI) and hemodynamic characteristics to assess relationship between RV morphology load In 53 (35 18 IPAH) diagnosed by heart catheterization (RHC), we examined cMRIs obtained within 48 hours of RHC compared groups. Regression...
The rapidly evolving COVID-19 pandemic has led to increased use of critical care resources, particularly mechanical ventilators. Amidst growing concerns that the health system could face a shortage ventilators in future, there is need for an affordable, simple, easy use, emergency stockpile ventilator.
Right heart catheterization (RHC) is needed to diagnose pulmonary hypertension (PH). Traditional hemodynamic determinations may be insufficient identify early stages of the disease and mechanism PH, confidently allocate patients pre- and/or postcapillary groups guide certain treatment decisions (e.g. use calcium channel blockers). In this review, we discuss role established (pulmonary vasodilatory, exercise rapid fluid infusion challenges) promising maneuvers (passive leg raising,...
Rationale: Current guidelines recognize the utility of provocative maneuvers during right heart catheterization to aid diagnosis pulmonary hypertension. Few studies have compared performance different provocation maneuvers. Objectives: To assess hemodynamic correlation among three maneuvers, including their effect on hypertension classification. Methods: This prospective trial was conducted between October 2016 and May 2018. Adult patients underwent catheterization: passive leg raise (PLR),...
The Centers for Disease Control and Prevention guidelines the prevention of catheter-related bloodstream infections suggest using “a subclavian site, rather than an internal jugular or a femoral in adult patients.” This recommendation is based on evidence lower rates thrombosis patients with central venous catheters (CVCs) compared to sites. However, preference toward approach CVC insertion hindered by increased risk mechanical complications, especially pneumothorax, when other largely...
We describe an elderly patient presenting with pneumothorax, cystic lung disease and a scalp lesion. The pneumothorax resolved after placing chest tube suction but recurred within week. Progression of features was also seen, biopsies the lesions were performed. Immunohistochemistry positive for markers endothelial cells (CD31 ERG) negative expected to be in alveolar (keratin AE1/AE3 TTF-1), supporting diagnosis metastatic angiosarcoma. Palliative chemotherapy did not prevent progression...
Objective: To evaluate methods for determining excessive short-term decline in forced expiratory volume one second (FEV1) diacetyl-exposed workers. Methods: We evaluated five of longitudinal FEV1 workers and from a comparative cohort: American Thoracic Society (ATS), ACOEM an 8% limit, relative absolute limit on the basis spirometry data variability. Relative risk incidence excess were evaluated. Results: Incidence was 1% cohort using ATS criteria, 4.1% decline, 4.4% with 5.6% by limit....
Governing bodies of graduate medical education recommend conducting interviews virtually. Although most programs remain compliant with this guidance, it is unclear if broadly supported by interviewees. Virtual interview (VI), in-person (IPI), and virtual an optional visit (VI+) formats have unique strengths weaknesses. We sought to evaluate process. To 1) determine which format applicants prefer, 2) identify factors that influence applicant preference, 3) applicants' perceived ability a...