A5062797306- Neuroblastoma Research and Treatments
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Circadian rhythm and melatonin
- HER2/EGFR in Cancer Research
- bioluminescence and chemiluminescence research
- Electromagnetic Fields and Biological Effects
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Cancer, Lipids, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Renin-Angiotensin System Studies
- Platelet Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Breast Cancer Treatment Studies
- Antioxidant Activity and Oxidative Stress
- Epigenetics and DNA Methylation
- Pesticide Exposure and Toxicity
- Signaling Pathways in Disease
- Phagocytosis and Immune Regulation
- Blood Pressure and Hypertension Studies
Universitätsmedizin Göttingen
2007-2019
University of Göttingen
2005-2016
Klinikum Fürth
2007
Universität Ulm
2003-2004
Universitäts Frauenklinik
2003-2004
University of Tübingen
1994-2003
Klinikum Arnsberg
1996-1999
University Children's Hospital Tübingen
1985-1999
Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor 2 (Her-2). They are neither susceptible to endocrine therapy nor a using the anti-Her-2 antibody, trastuzumab. Therefore, an efficient targeted is warranted. tumors frequently express membrane bound G-protein coupled (GPR30). As proof of principle, we analyzed consequences knock-down GPR30 expression on regulation triple-negative cancer cell lines. Cells...
Abstract: Melatonin possesses anti‐estrogenic effects on estrogen receptor expressing (ER+) breast cancer cells in culture by reducing cell cycle progression and proliferation. There is increasing agreement that a cellular level the of melatonin are primarily induced membrane‐bound MT1. The participation second, nuclear group ligand‐dependent transcription factors, called RZRα, under debate. In this study we used number lines differing their expression two known receptors. MCF‐7 transfected...
Metastasis to bone is a frequent problem of advanced breast cancer. Particularly cancers, which do not express estrogen receptor α (ERα) and progesterone (PR) have no overexpression human epidermal growth factor 2 (HER2), so‑called triple‑negative cancers (TNBCs), are considered as very aggressive poor prognosis. Recently we shown that cancer cell invasion was dramatically increased when co‑cultured with MG63 osteoblast‑like cells. Using this model now analyzed whether β (ERβ) plays role in...
Breast cancer is the most common malignancy of women in Western societies. The increasing exposure to electromagnetic fields has been suspected contribute rising incidence breast industrialized countries. majority tumors treated with partial antiestrogen tamoxifen. Most become resistant tamoxifen course treatment resulting failure. Electromagnetic reduce efficacy similar resistance. In this study we investigated mechanism by which influence sensitivity cells exposed 1.2 microT a 50 Hz field...
BackgroundThe direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of beyond its properties less clear. This study investigates antifibrotic nephroprotective effects in nonhypertensive mouse model for progressive renal fibrosis.
Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate integrity of glomerular basement membrane (GBM) by sensing presence collagen and regulating IV synthesis. The present study evaluates role integrin α2 (ITGA2) in cell-matrix interaction.ITGA2-deficient mice had normal renal function but moderate proteinuria enhanced tubulointerstitial matrix deposition. Electron microscopy demonstrated irregular podocyte-matrix interaction, causing...
Treatment of neuroblastoma is an unsolved problem pediatric oncology. In spite highly intensified chemotherapy, the long-term survival rate children with a metastatic below 10%. We therefore used 131I-metaiodobenzylguanidine (MIBG) for first time to treat in relapse or primary unresponsiveness chemotherapy. had previously demonstrated that MIBG useful scintigraphic imaging lesions and investigated cytotoxicity uptake various cell lines. treated 6 total 19 courses. Three suffered from...
The COL4A3−/− mouse serves as animal model for progressive renal fibrosis. Using this model, the present study investigates nephroprotective effects of Paricalcitol versus Calcitriol alone and on top ACE-inhibitor therapy. Eighty six mice were divided into groups: (PC) with 0.1 mcg/kg, (CA) 0.03 mcg/kg (dose equipotent), (PLAC) vehicle mL i.p. five times per week, (ACE + PC) plus Ramipril, CA) Ramipril PLAC) 10 mg/kg/day p.o. ACE therapy started pre-emptively in Week 4, PC/CA was initiated...
Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible endocrine therapy using antiestrogens. However, majority TNBCs express membrane bound estrogen receptor GPR30. We have recently shown that knock-down GPR30 expression prevented growth stimulation TNBC cell lines by 17β-estradiol. Now we analyzed whether specific inhibition represents a new option for TNBC. Growth cells was assessed Alamar-blue colorimetric assay. Activation c-Src and EGF-receptor Western...
The growth of estrogen-receptor positive breast cancer cells is inhibited by the pineal gland hormone, melatonin. Concern has been raised that power-line frequency and microwave electromagnetic fields (EMFs) could reduce efficiency melatonin on cells. In this study we investigated impact EMFs signal transduction high-affinity receptor MT1 in parental MCF-7 transfected with gene. binding cAMP-responsive element (CREB) protein to a promoter sequence BRCA-1 after stimulation was analyzed...
Effects of electromagnetic fields (EMFs) on the incidence breast cancer (BC) have been proposed by a number epidemiological studies. The molecular mechanism impact EMFs cells is not yet clear, although changes in gene expression reported various cellular systems. In this investigation, interference low-frequency with plasminogen activator system was examined BC cells. MCF-7 from 2 different sources were exposed to highly homogeneous 50-Hz EMFs. Changes analyzed reverse...
Angiotensin-converting enzyme inhibitors (ACEi) delay progression of the inherited renal disease Alport syndrome. However, effect ACEis weakens gradually due to an “aldosterone escape”. Here, we investigate if aldosterone antagonist can counteract loss ACEi-efficacy. COL4A3-/- mice were treated with ramipril (ACEi), starting at 4.5 weeks age, and spironolactone was added 7 age. Lifespan until failure, as well kidney function parameters, investigated. Dual therapy decreased proteinuria levels...
Currently, conventional chemotherapy is the only treatment option for triple-negative breast cancers (TNBC) due to a lack of unique target. In TNBC, high expression membrane bound G protein-coupled estrogen receptor (GPER), correlates with worse outcome. There potential an association between growth hormone (GHR) and GPER expression. To confirm this hypothesis, GHR was inhibited in TNBC cells Somavert, levels, effect on signal transduction proliferation induction were analyzed. Proliferation...