A5055613619- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Fetal and Pediatric Neurological Disorders
- Genomic variations and chromosomal abnormalities
- Gestational Trophoblastic Disease Studies
- Spaceflight effects on biology
- Parvovirus B19 Infection Studies
- Pregnancy-related medical research
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Reproductive Health and Technologies
- Epigenetics and DNA Methylation
- Calpain Protease Function and Regulation
- Congenital Anomalies and Fetal Surgery
- Alkaline Phosphatase Research Studies
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Macrophage Migration Inhibitory Factor
- Bone and Dental Protein Studies
Nagoya City University
2015-2025
Nara Medical University
2024
Karolinska Institutet
2019-2022
Nagoya Memorial Hospital
2009-2021
BioClinicum (Russia)
2019
Nagoya City University Hospital
2015
Gifu University
1952-2008
Oita Medical Center
1991
There have been few studies concerning an association between unexplained recurrent pregnancy loss (RPL) and the microbiome. A recent study including 67 patients demonstrated that increase in Ureaplasma species endometrium raised risk of miscarriage with euploid karyotype. While endometrial sampling is invasive, cervicovaginal not. We compared vaginal cervical microbiomes a 16 S ribosomal RNA sequence 88 RPL 17 healthy women no history miscarriage. prospectively assessed factors for maternal...
Abstract Cranial radiotherapy in children has detrimental effects on cognition, mood, and social competence young cancer survivors. Treatments harnessing hippocampal neurogenesis are currently of great relevance this context. Lithium, a well-known mood stabilizer, both neuroprotective, pro-neurogenic as well antitumor effects, the current study we introduced lithium treatment 4 weeks after irradiation. Female mice received single Gy whole-brain radiation dose postnatal day (PND) 21 were...
Sporadic early miscarriages occur primarily due to embryonic aneuploidy. There is no evidence showing that stress a direct cause of miscarriage. Yet, despite this, national US survey and Japanese found many people mistakenly attributed miscarriage the mental state or behavior women. Our present examined risk factors economic impact resignation associated with pregnancy in Japan. The questionnaire be completed consisted 17 questions concerning individual characteristics from workforce. Of...
ABSTRACT Objective The objective of our study was to describe clinical experience in providing noninvasive prenatal testing (NIPT) for fetal aneuploidy pregnant women, highlighting the degree non‐specific psychological distress. Methods Data were collected from Japanese women who offered and underwent NIPT after genetic counseling control did not undergo as part Japan Environment Children's Study Control A planning. mental distress assessed using Kessler 6 (K6) screening scale with a score...
Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological pathological processes, including the widespread use Cx3cr1CreER-Eyfp/wt mouse strain for studies microglia.Immunohistochemistry, Flow Cytometry, RNA sequencing whole-genome were used to identify subpopulation microglia in brains. Genetically mediated depletion using Cx3cr1CreER-Eyfp/wtRosa26DTA/wt mice CSF1 receptor inhibitor PLX3397 deplete microglia....
Abstract Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained (uRPL). Here, we perform genome-wide association study focusing on uRPL in 1,728 24,315 female controls Japanese ancestry. We detect significant associations...
Omphalocele-exstrophy of the bladder (cloaca)-imperforate anus-spinal defects (OEIS) complex describes a rare grouping more commonly occurring component malformations. We report two cases OEIS diagnosed prenatally by ultrasound and magnetic resonance imaging (MRI). In both cases, was suspected conventional sonography in second trimester, fetal MRI performed at 27 32 weeks gestation. Conventional revealed low abdominal wall mass, spina bifida, absent ambiguous genitalia, but those findings...
An indoleamine 2,3-dioxygenase (IDO) and a tryptophan (TDO) lead to dysfunction of T cell immunological tolerance between fetus mother in early pregnancy. We investigated the role IDO TDO patients with recurrent miscarriage.Cervical mucus, decidua, villi were surgically collected from miscarriage April 2010 March 2013. Samples cervical mucus divided into two groups: delivery group group. The samples miscarried tissue decidua normal chromosome (normal analysis villi) abnormal (abnormal...
In a previous study, we reported that the cathepsin-cystatin system caused endometrial dysfunction in early pregnancy. Here, investigated existence and contribution of cathepsin E pregnancy patients with recurrent miscarriage (RM). The effect deficiency on fertility female reproductive organs were also analyzed CatE−/− mice. Human studies conducted hospital setting, informed consent. Cervical mucus was collected from RM (4–6 gestational weeks, n = 21), outcome compared prospectively....
Abstract Parental decision‐making to terminate or continue a pregnancy was studied after prenatal diagnosis of chromosome aneuploidy among sample patients around the city Nagoya, Japan. A total 1,051 amniocentesis cases at 15–18 weeks gestation were analyzed. Of these, 60 chromosomal anomalies with aneuploidies diagnosed by conventional cytogenetic analysis. 45 diagnoses autosomal aneuploidies, terminated in 93.3 % cases. 15 sex aneuploidy, 46.7 %. Differences parental decisions respect...
The association between subclinical hypothyroidism (SCH) and recurrent pregnancy loss (RPL) remains unclear. We evaluated whether SCH affects subsequent live births levothyroxine is effective in improving the birth rate patients with RPL.This observational cohort study included 1418 pregnancies of 1014 a history 2 or more losses, who were euthyroid had hypothyroidism, at least one outcome. Some SCH, as defined TSH >2.5 mIU/L, treated levothyroxine, these comprised group. prevalence rates per...
Abstract STUDY QUESTION Can antinuclear antibodies (ANA) affect the subsequent live birth rate (LBR) in patients with unexplained recurrent pregnancy loss (RPL) absence of antiphospholipid (aPL)? SUMMARY ANSWER Women RPL have a high probability following positive test (>70%), being similar between those and negative ANA testing, regardless cut-off value. WHAT IS KNOWN ALREADY The guidelines ESHRE state that ‘ANA testing can be considered for explanatory purposes’. However, there been...
Microangiopathic antiphospholipid-associated syndromes (MAPSs) are reported as encompassing several conditions mainly affecting the microvasculature of selected organs: liver in HELLP syndrome (hemolysis, elevated enzymes, and low platelet); kidney, brain, skin TTP (thrombotic thrombocytopenic purpura). It is predominant patients with catastrophic antiphospholipid (APS). A recent report suggests that APS not only a thrombotic disease but also associated microangiopathic features, it can...
Abstract Sacrococcygeal teratoma (SCT) is a rare congenital disease and prognostic factors have not been entirely established. We report two cases of fetal SCT with different clinical courses. Case 1 was cystic, slow growing tumor mild vascularity. The removed one week after delivery at 35 weeks, there no recurrence 1.5‐year follow‐up. 2 solid, rapid rich Cesarean section performed due to severe hydrops mirror syndrome in the mother 27 weeks. had ruptured soon control bleeding, but baby died...
The aim of the present study was to examine primary cilia in endometrial tissue during menstrual cycle and clarify their morphological changes with different grades cancer. Images fluorescence immunostaining taken by confocal microscopy were used count number normal endometrium endometrioid carcinoma Grade 1 3 specimens. To association between autophagy ciliogenesis carcinoma, expression p62/Sequestosome-1, a selective substrate for autophagy, oral-facial-digital syndrome protein (OFD1),...