A5020084720- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Management and Research
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Multiple Sclerosis Research Studies
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Pluripotent Stem Cells Research
- Natural Antidiabetic Agents Studies
- Parkinson's Disease Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
Ottawa Hospital
2016-2024
University of Ottawa
2024
Ottawa Hospital Research Institute
2016-2024
Rationale: Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is potential target for neurodegenerative diseases, such as Alzheimer's disease (AD). Increasing evidence shows impairment of adult neurogenesis by perturbed lipid metabolism predisposes patients AD. However, it remains unknown what causes aberrant expression Mgll in AD and how Mgll-regulated impacts neurogenesis, thus predisposing...
While transplantation of human induced pluripotent stem cell-derived neural cells (hiPSC-NSCs) shows therapeutic potential in animal stroke models, major concerns for translating hiPSC therapy to the clinic are efficacy and safety. Therefore, there is a demand develop an optimal strategy enhance engraftment regenerative capacity transplanted hiPSC-NSCs produce fully differentiated replace lost brain tissues. Metformin, FDA-approved drug, neuroregenerative agent that not only promotes NSC...
Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage releases micro-environmental cues, we examined role a signaling-induced epigenetic pathway, an atypical protein kinase C (aPKC)-mediated phosphorylation CREB-binding (CBP), in post-stroke neurovascular remodeling. Using knockin mouse strain (CbpS436A) where aPKC-CBP pathway was defective, show disruption murine...
While epigenetic modifications have emerged as attractive substrates to integrate environmental changes into the determination of cell identity and function, specific signals that directly activate these remain unknown. Here, we examine role atypical protein kinase C (aPKC)-mediated Ser436 phosphorylation CBP, a histone acetyltransferase, in adult hippocampal neurogenesis memory. Using knockin mouse strain (CbpS436A) which aPKC-CBP pathway is deficient, observe impaired neuronal...
Multiple sclerosis (MS) negatively impacts cognition and has been associated with deficits in social cognition, including emotion recognition. There is a lack of research examining recognition from multiple modalities MS. The present study aimed to employ clinically available measure assess multimodal abilities among individuals
Brain pericytes can acquire multipotency to produce multi-lineage cells following injury. However, are a heterogenous population and it remains unknown whether there different potencies from subsets of in response
Epigenetic modifications have become an emerging interface that links extrinsic signals to alterations of gene expression determine cell identity and function. However, direct signaling regulates epigenetic is unknown. Our previous work demonstrated phosphorylation CBP at Ser 436 by atypical protein kinase C (aPKC) age-dependent hippocampal neurogenesis memory. p300, a close family member CBP, lacks the aPKC-mediated found in CBP. Here, we use phosphorylation-competent p300 (G442S) knock-in...
Background: Diabetes (DM), a common comorbidity, results in poorer cognition people with multiple sclerosis (MS). Metformin may be treatment option given cognitive benefits. represses monoacylglycerol lipase (Mgll), accompanied by improvements animals. Aims were to determine 1) whether metformin Mgll humans, 2) if correlates cognition/emotion recognition, and 3) differs between groups.Methods: Seventeen MS DM on metformin, 4 not 10 MS, 21 healthy controls completed BICAMS measures of...
Abstract Background Diabetes (DM), a common comorbidity, results in poorer cognition people with multiple sclerosis (PwMS). Metformin may be treatment option given cognitive benefits. represses monoacylglycerol lipase (Mgll), accompanied by improvements animals. Aims To determine 1) whether metformin Mgll humans, 2) if correlates cognition/emotion recognition, and 3) differs between groups. Methods A convenience sample of seventeen PwMS DM on metformin, 4 MS not 10 MS, 21 healthy controls...