A5017456307- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Indigenous Studies and Ecology
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Heavy metals in environment
- Nutritional Studies and Diet
- Trace Elements in Health
- Marine animal studies overview
- Indigenous Health, Education, and Rights
- Environmental Toxicology and Ecotoxicology
- Selenium in Biological Systems
- Effects and risks of endocrine disrupting chemicals
- Fatty Acid Research and Health
- Arctic and Russian Policy Studies
- Food Security and Health in Diverse Populations
- Arsenic contamination and mitigation
- Fluoride Effects and Removal
- Environmental Justice and Health Disparities
- Per- and polyfluoroalkyl substances research
- Diet and metabolism studies
- Child Nutrition and Water Access
- Carcinogens and Genotoxicity Assessment
- Isotope Analysis in Ecology
- Aquaculture Nutrition and Growth
University of Ottawa
2016-2025
Hong Kong Polytechnic University
2013-2024
Shenzhen Polytechnic
2020
Ontario Genomics
2012-2019
Marie Curie
2019
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
Albert Einstein College of Medicine
2019
University of Northern British Columbia
2006-2015
Novartis (Switzerland)
2015
Health Canada
2015
Mercury (Hg) is a global pollutant that affects human and ecosystem health. We synthesize understanding of sources, atmosphere-land-ocean Hg dynamics health effects, consider the implications Hg-control policies. Primary anthropogenic emissions greatly exceed natural geogenic resulting in increases reservoirs subsequent secondary facilitate its distribution. The ultimate fate emitted primarily recalcitrant soil pools deep ocean waters sediments. Transfers to largely unavailable occur over...
Objectives. The food supply of Inuit living in Nunavut, Canada, is characterized by market relatively low nutritional value and nutrient-dense traditional food. objective this study to assess community perceptions about the availability accessibility foods Nunavut.Study Design. A qualitative using focus group methodology.Methods. Focus groups were conducted 6 communities Nunavut 2004 collected information was analyzed.Results. Barriers increased consumption included high costs hunting...
The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is frequently dysregulated in cancers, and gain-of-function (GOF) EZH2 mutations have been identified non-Hodgkin lymphomas. Small-molecule inhibitors against demonstrated anti-tumor activity EZH2-mutated lymphomas entered clinical trials. Here, we developed models acquired resistance to inhibitor EI1 with lymphoma cells. Resistance was generated by secondary both wild-type (WT) GOF Y641N alleles. These mutants retained the...
There is increasing evidence that selenium (Se) has a significant effect on mercury (Hg) toxicology; however, Hg exposure risk assessments usually consider only the amount of present in environment or food. On basis understanding mechanisms interaction between Se and Hg, physiology/toxicology Se, toxicology we propose new criterion for Se/Hg assessment. This criterion, which based Se-Hg interactions, considers not toxicological consequences but also benefits and/or adverse effects intake,...
The role of the placenta was assessed by comparing profiles methylmercury (MeHg), inorganic mercury (I-Hg), lead (Pb), cadmium (Cd), selenium (Se), zinc (Zn), and copper (Cu) in freeze-dried chorionic tissue umbilical cord tissue. significance as predictors prenatal exposure to these trace elements pregnant women newborns also examined element among tissue, maternal blood red cells (RBCs). samples were collected from 48 mother–child pairs at birth general population Japanese. concentrations...
Occupational exposures to combustion emissions were examined in Ottawa Fire Service (OFS) firefighters. Paired urine and dermal wipe samples (i.e., pre- post-event) as well personal air fire event questionnaires collected from 27 male OFS A total of 18 office workers used additional controls. Exposures polycyclic aromatic hydrocarbons (PAHs) other organic mutagens assessed by quantification urinary PAH metabolite levels, levels PAHs wipes samples, mutagenicity using the Salmonella assay...
The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, OBS evaluate bioconcentration acute metabolic consequences. Per- polyfluoroalkyl substances (PFASs) accumulated larvae order of F-53B > OBS, with factors ranging from 20 357. Exposure not increased energy...