About
Contact & Profiles
A5086095967
Research Areas
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Redox biology and oxidative stress
- Electron Spin Resonance Studies
University of Florida
2018
Abstract Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes conversion of isocitrate to α-ketoglutarate NADP + NADPH. In mitochondria, IDH2 also plays a key role protecting mitochondrial components from oxidative stress by supplying NADPH both glutathione reductase (GSR) thioredoxin (TXNRD2). Here, we report that loss Idh2 accelerates age-related hearing loss, most common form impairment, male mice. This was accompanied increased DNA damage, apoptotic cell death,...
10.1038/s41598-018-23436-w
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Scientific Reports
2018-03-22
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