Guidelines recommend endoscopic surveillance for gastric cancer without therapeutic intervention every 3 years in patients with high-risk intestinal metaplasia (GIM). This study aimed to evaluate the efficacy of radiofrequency ablation (RFA) eradicating GIM. randomized self-control trial was conducted between June 2020 and February 2023. Patients histology-verified GIM were enrolled. The endoscopist performed a biopsy on both left right sides stomach (five each) by targeting suspected area...

Gastric intestinal metaplasia (GIM) is the premalignant stage of gastric cancer; however, consensus on its management has not been established.To determine risk factors for cancer in a population patients with GIM to guide appropriate clinical recommendations low prevalence area cancer.This was retrospective cohort study. Ninety-one diagnosed between 2004 and 2014 were recruited surveillance EGD every 6-12 months until diagnosis or completion planned 5-year follow-up duration. Possible...

Previous artificial intelligence (AI) models attempting to segment gastric intestinal metaplasia (GIM) areas have failed be deployed in real-time endoscopy due their slow inference speeds. Here, we propose a new GIM segmentation AI model with speeds faster than 25 frames per second that maintains high level of accuracy.Investigators from Chulalongkorn University obtained 802 histological-proven images for training. Four strategies were proposed improve the accuracy. First, transfer learning...

A missense mutation in exon 7 (R249S) of the p53 tumor suppressor gene is characteristic aflatoxin B1 (AFB1) exposure. AFB1 believed to have a synergistic effect on hepatitis virus B (HBV) carcinogenesis. However, results studies comparing R249S prevalence among patients are conflicting. The aim this study was determine hepatocellular carcinoma (HCC) with or without positive HBsAg.Paraffin embedded liver tissues were obtained from 124 HCC who underwent resection and biopsy King Chulalongkorn...

Most of the available data on pancreatic cancer are from Western countries. The aim was to characterize in Asian patients and compare it with Caucasians.Inpatients histologically proven were retrospectively recruited at King Chulalongkorn Memorial Hospital January 2005 December 2011.The study enrolled 100 (male:female = 55:45, mean age 62.7 ± 12.9 years). amount time between symptom onset disease diagnosis 59.89 63.12 days. common presenting symptoms included abdominal pain or discomfort...

Background and study aims According to a recent guideline, patients with gastric intestinal metaplasia (GIM) should have at least five biopsies performed under the Sydney protocol evaluate for risk of extensive GIM. However, only narrow-band imaging (NBI)-targeted biopsy may be adequate diagnose Patients methods A cross-sectional was conducted between November 2019 October 2020. histology-proven GIM were enrolled. All underwent standard esophagogastroduodenoscopy by gastroenterology trainee....

Abstract Background Diagnostic laparoscopy is often a necessary, albeit invasive, procedure to help resolve undiagnosed peritoneal diseases. Previous retrospective studies reported that EUS-FNA feasible on and omental lesions, however, provided limited amount of tissue for immunohistochemistry stain (IHC). Aim This pilot study aims prospectively determine the effectiveness EUS-FNB regarding adequacy IHC staining, diagnostic rate avoidance or percutaneous biopsy in patients with these...

e15175 Background: Ampullary cancer has been regards to have a better prognosis than the other periampullary tumors. Certain data suggests that difference may stem from certain distinct biology such as K-ras mutation. Prior reports show large variation of prevalence mutation 0 75% in ampullary carcinomas. We sought characterize ofK-ras mutations carcinoma Thai patients. Methods: reviewed hospital medical records patients who were treated at King Chulalongkorn Memorial Hospital (KCMH) 1 Jan...

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Abstract Background Gastrointestinal stromal tumor (GIST) was the most common mesenchymal of gastrointestinal tract predominately occurring in stomach. Although GIST a rare disease, it considered to be life-threatening malignancy. Objective To explore current status gastric Thai patients. Method The medical records patients who were diagnosed with histologically proven from 2012 2016 King Chulalongkorn Memorial Hospital reviewed. Results Of 22 patients, there 14 (63.6%) females and 8 (36.4%)...

Abstract Background: Helicobacter pylori (H. pylori) are a major cause of chronic gastritis and peptic ulcer. This organism plays role in gastric carcinoma B-cell lymphoma. However, the exact pathogenesis inflammation is still unclear. Mast cells, important inflammatory cells for allergic process, may participate related to H. infection. Objective: Analyze relationship between mast cell density, intensity, histological alterations, their severity biopsy proven gastritis. Methods: One hundred...

Gastric intestinal metaplasia (GIM) is a premalig-nant lesion that can evolve into gastric cancer. It challenging to detect and segment since it doesn't have concrete boundary its shape flat. Furthermore, crucial for the model perform in real-time fashion during esophagogastroduodenoscopy (EGD). Although recent deep learning approaches shown promising segmentation performance, they failed constrain inference speed. In this paper, we propose employ network called "Fast Segmentation...

Abstract Background: Liver is the most common distant metastasized organ in advanced colon cancer. Surgical resection of metastatic lesions would offer best chance a long-term survival. An accurate diagnosis and evaluation extent disease crucial management liver metastasis. Objective: Report benign hepatic condition mimicking metastasis cancer patient. Case presentation: A 53-year-old male with an early stage sigmoid was treated sigmoidectomy followed by adjuvant chemotherapy consisting...

206 Background: Cholangiocarcinoma in Thailand and Laos is associated with the liver fluke Opisthorchis viverrini (OV). Molecular differences between OV-CCA Non-OV CCA remain to be defined. MiRNAs are regulators of mRNA that result transcriptional repression or gene silencing. MiRNA profiles OV vs. non-OV have not yet been studied. Methods: 50 16 pathological samples were obtained from Liver Fluke Center, Khonkaen University, University Texas, MD Anderson Cancer Center (MDACC), USA,...

Gastric intestinal metaplasia (GIM) is a premalignant condition of intestinal-type gastric cancer. However, its management not well-established. The objective this study was to determine the risk factors for cancer in population patients with GIM order propose appropriate clinical recommendations setting low prevalence area Ninety-one previously diagnosed between 2004 and 2014 were recruited surveillance EGD every 6 12 months until diagnosis or completion planned 5-year follow-up duration....

To prospectively study impact and amount of tissue for immunohistochemical staining (IHCS) EUS-FNB from peritoneal lesions.