A5020211340- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Pharmacological Effects and Assays
- Pneumonia and Respiratory Infections
- Cystic Fibrosis Research Advances
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Respiratory and Cough-Related Research
- Advanced Chemical Sensor Technologies
- Microencapsulation and Drying Processes
- Pesticide Residue Analysis and Safety
- Antibiotic Resistance in Bacteria
- Microfluidic and Capillary Electrophoresis Applications
- Airway Management and Intubation Techniques
- Aerosol Filtration and Electrostatic Precipitation
- Pulmonary Hypertension Research and Treatments
- Analytical Chemistry and Sensors
- Advancements in Transdermal Drug Delivery
- Refrigeration and Air Conditioning Technologies
- Natural product bioactivities and synthesis
- Phytochemistry and biological activity of medicinal plants
- Combustion and Detonation Processes
- Telemedicine and Telehealth Implementation
- Bone health and treatments
- Hormonal and reproductive studies
University of Bradford
2015-2024
King Saud University
2016
Bharati Vidyapeeth Deemed University
2007
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge encapsulation efficiency shape, glass transition temperature (Tg), water content in vitro deposition were determined. Antimicrobial activity against (CF) pathogens determined by MIC, MBC biofilm assays. Cytotoxicity cellular uptake studies performed using A549 cells. The average size...
Epigallocatechin gallate (EGCG), the main ingredient in green tea, holds promise as a potential treatment for pulmonary arterial hypertension (PAH). However, EGCG has many drawbacks, including stability issues, low bioavailability, and short half-life. Therefore, purpose of this research was to develop optimize an inhalable nano-liposome formulation aiming overcome EGCG's drawbacks by applying design experiments strategy. The aerodynamic behaviour optimum determined using next-generation...
Previously, dose emission below 30 L min−1 through DPI has not been routinely determined. However, during routine use some patients do achieve inhalation flows. Hence, the aim of present study was to determine characteristics for low flows from terbutaline sulphate Turbuhaler.
Some dry powder inhalers have profound inhalation flow rate-dependent dosage emission, and it has been suggested that there are links between the in vitro emitted dose, total lung deposition, subsequent clinical response. We measured delivery for a combination of budesonide eformoterol new version Turbuhaler. At rates 30, 60, 90 Lmin-1, dose emission 10 separate inhalations from each six was determined. The aerodynamic characteristics using 28.3 60 Lmin-1 were Andersen Cascade Impactor. mean...
Objectives To evaluate the applicability of ultrasonic energy in designing particles with desired properties and to investigate effect mechanistic on using different tools.Introduction Application (US) particle engineering has been reported last decade.The main advantage application US is achievement crystallization at relatively longer degrees supersaturation.In sonocrystallization process, nucleation steps are significantly altered.The metastable zone reduced occurs lower degree super...
The aim of the study was to determine relative lung and systemic bioavailability terbutaline.On separate days healthy volunteers received 500 µg terbutaline doses either inhaled from a metered dose inhaler or swallowed as solution with without oral charcoal. Urine samples were provided at timed intervals post dosing.Mean (SD) urinary 0.5 h inhalation, in 12 volunteers, (IC) (I) charcoal (O) dosing 7.4 (2.2), 6.5 (2.1) 0.2 (0.2) µg. I IC similar both significantly greater than O (P<0.001)....
Abstract: Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM particle size 161±1.5 nm polydispersity index 0.172±0.01 were produced in <1 hour using wet milling technology, Dena ® DM-100. The crystallinity the processed was confirmed differential scanning calorimetry powder X-ray diffraction. saturation substantially increased to 900 µg/mL compared raw water (145.0±2.3 µg/mL) stabilizer solution...
Pharmaceutical salt, nitrofurantoin–4-dimethylaminopyridine (NF-DMAP), along with its native components NF and DMAP are scrutinized by FT-IR FT-Raman spectroscopy density functional theory so that an insight into the H-bond patterns in respective crystalline lattices can be gained. Two different functionals, B3LYP wB97X-D, have been used to compare theoretical results. The spectra obtained for NF-DMAP clearly validate presence of C33–H34⋅⋅⋅O4 N23–H24⋅⋅⋅N9 hydrogen bonds shifting stretching...
Pulmonary arterial hypertension (PAH) is a progressive and rare condition characterised by the occlusion of pulmonary arterioles, with clinical manifestations resulting from cross-sectional area reduction small arteries. The disease driven combination factors including vasoconstriction, thrombosis, inflammation, proliferation, obstructive remodelling artery walls. Heterozygous mutations in type II bone morphogenetic protein receptor (BMPR2) underlie majority inherited familial forms PAH....